Prophylactic vancomycin to prevent staphylococcal septicaemia in very-low-birth-weight infants

Möller, J.; Nachtrodt, Gerald; Richter, A; Tegtmeyer, FriedrichK.

doi:10.1016/0140-6736(92)91502-y

Cited by 14 publications

(2 citation statements)

References 5 publications

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“…Sir, Sepsis caused by coagulase-negative staphylococci (CONS) is of major importance in very low birthweight (VLBW) infants, occurring in 10-40% of patients (1). The major cause is essential intravenous lines, and no easy preventive strategy exists (1). CONS sepsis increases the rate of BPD and days in hospital (2).…”

mentioning

confidence: 99%

Teicoplanin pharmacology in prophylaxis for coagulase‐negative staphylococcal sepsis of very low birthweight infants

Nelskamp

Jensen

et al. 1996

Acta Paediatrica

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mentioning

confidence: 99%

Teicoplanin pharmacology in prophylaxis for coagulase‐negative staphylococcal sepsis of very low birthweight infants

Nelskamp

Jensen

et al. 1996

Acta Paediatrica

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“…As strict hygienic measures are of only marginal efficacy in reducing the rate of CONS sepsis [5][6][7], prophylactic treatment with low doses of vancomycin (4-10 mg/kg/ day) has been introduced for high-risk popula tions [3,6,[8][9][10], Vancomycin is a well-estabNosocomial sepsis with coagulase-negative staphylococci (CONS) contributes signifi cantly to the mortality of very-low-birthweight (VLBW) infants. Up to 40% of the VLBW infants (in our institution 24%) ac in our patients studied.…”

Section: Introductionmentioning

confidence: 99%

Prophylactic Low-Dose Vancomycin Treatment in Very-Low-Birth-Weight Infants

Jc¹,

Nachtrodt²,

Tegtmeyer³

et al. 1992

Dev Pharmacol Ther

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For the prophylaxis of septicemia with coagulase-negative staphylococci in a high-risk very-low-birth-weight population, we administered 5 mg/kg of vancomycin every 12 h. Distribution volume and half-life of vancomycin were determined. Serum peak and trough levels were obtained on day 3 of treatment. With this low-dose regimen, serum concentrations in the therapeutic range were achieved in 35 of the 45 patients. Distribution volume and half-life were 0.692 liters/kg and 7.4 h, respectively. The distribution volume was not related to the gestational age; the half-life in the group of patients with a gestational age <30 weeks was considerably higher. The 10 small-for-gestational-age children had a significantly smaller distribution volume. The vancomycin trough levels correlated with the serum creatinine concentrations and, therefore, with the gestational age. Our study indicates that this low vancomycin dose is sufficient in very-low-birth-weight infants to achieve therapeutic serum levels, being suitable for both prophylaxis and sepsis therapy.

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Neugeborenensepsis und -meningitis

Isenberg

1998

Meningitis Im Kindesalter Und Neugeborenensepsis

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Prophylactic vancomycin to prevent staphylococcal septicaemia in very-low-birth-weight infants

Cited by 14 publications

References 5 publications

Teicoplanin pharmacology in prophylaxis for coagulase‐negative staphylococcal sepsis of very low birthweight infants

Teicoplanin pharmacology in prophylaxis for coagulase‐negative staphylococcal sepsis of very low birthweight infants

Prophylactic Low-Dose Vancomycin Treatment in Very-Low-Birth-Weight Infants

Neugeborenensepsis und -meningitis

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