Prophylaxis of Striae gravidarum with a topical formulation. A double blind trial

Abstract

Synopsis A prophylactic antistriae cream (Centella asiatica extract, alpha-tocopherol, and collagen-elastin hydrolisates) was assessed by a double blind trial in 80 pregnant women. In the placebo group 22 women (56%) presented striae, whereas in the treated group only 14 women (34%) developed striae in this pregnancy; this difference was significant (p < 0.05; chi(2) test). An arbitrary score was designed to assess the intensity of striae (from 0 to 3); this score was 1.42 (sd 0.5) in the treated group and 2.13 (sd 1.32) in the placebo group and this difference was also significant (p= 0.014; Mann-Whitney test). In women with a history of striae during puberty, the active cream induced a significant absolute prevention in 89% of the cases whereas in the placebo group all the women developed striae (p= 0.00014; chi(2) test).

Prevention of striae gravidarum with cocoa butter cream

“…Many creams have been used to prevent SG, but most have been found to be ineffective [3]. A cream containing Centella asiatica tested in clinical trials was found to be effective and resulted in a 60% reduction in SG in one study [4,5]. However, this product is not readily available in most countries.…”

Gebelik ve emzirme döneminde kozmesötik kullanımı

“…CentellaAsiatica(GotuKola)Ekstresi: Mallol ve ark. yaptığı çift kör klinik çalışmada, 40 kişilik plesebo grubunun (22) %56'sında, 40 kişilik tedavi grubunun (14) %34'ünde stria geliştiği saptanmış(p<0,05) 22 . Cocoa Butter (Kakoa Yağı): 2008 yılında yapılan, çok merkezli, çift kör, plasebo kontrollü, klinik çalışmada 91 hastaya cocoa butter, 84 hastaya plasebo uygulanmış.…”

Was hilft am besten bei Bindegewebsschwäche?

“…Gute Ergebnisse zur Prophylaxe von Schwangerschaftsstreifen brachte die topische Anwendung von Centella asiatica, einer Heilpflanze der traditionellen Medizin [24]. Studien über die lokale Anwendung von 20%iger Glykolsäure in Kombination mit 0,05%igem Tretinoin bzw.…”