Propionate and Alzheimer’s Disease

Killingsworth, Jessica; Sawmiller, Darrell; Shytle, R. Douglas

doi:10.3389/fnagi.2020.580001

Cited by 42 publications

(34 citation statements)

References 132 publications

(146 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Skin microbiota members, specifically Actinobacteria , are known to be propionate producers. In addition, saliva, fecal and hippocampus propionate levels have been found to increase significantly in Alzheimer’s disease patients [30]. Our results also suggest a potential association between the increase in propionate biosynthesis by skin microbiota and CI stages in PD.…”

Section: Discussionsupporting

confidence: 63%

Axillary Microbiota is Associated with Cognitive Impairment in Parkinson’s Disease Patients

Arıkan¹,

Yıldız²,

Demir

et al. 2021

Preprint

View full text Add to dashboard Cite

Introduction: Cognitive impairment (CI) is among the most common non-motor symptoms of Parkinson's disease (PD) with substantially negative impact on patient management and outcome. The development and progression of CI exhibits high interindividual variability which requires better diagnostic and monitoring strategies. PD patients often display sweating disorders resulting from autonomic dysfunction which has been associated with CI. As the axillary microbiota is known to change with humidity level and sweat composition, we hypothesized that axillary microbiota of PD patients shifts in association with CI progression thus can be used as proxy for classification of CI stages in PD. Methods: We compared the axillary microbiota compositions of 103 PD patients (55 PD patients with dementia (PDD) and 48 PD patients with mild cognitive impairment (PD-MCI)) and 26 cognitively normal healthy controls (HC). Results: We found that axillary microbiota profiles differentiate HC, PD-MCI and PDD groups based on differential ranking analysis and detected an increasing trend in the log ratio of Corynebacterium to Anaerococcus in progression from HC to PDD. In addition, phylogenetic factorization revealed that the depletion of Anaerococcus, Peptoniphilus and W5053 genera is associated with PD-MCI and PDD. Moreover, functional predictions suggested significant increase of myo-inositol degradation, ergothioneine biosynthesis, propionate biosynthesis, menaquinone biosynthesis, and the proportion of aerobic bacteria and biofilm formation capacity in parallel to CI. Conclusion: Our results suggest that alterations in axillary microbiota are associated with CI in PD. Thus, axillary microbiota holds potential to be exploited as a non-invasive biomarker in the development of novel strategies.

show abstract

Section: Discussionsupporting

confidence: 63%

Axillary Microbiota is Associated with Cognitive Impairment in Parkinson’s Disease Patients

Arıkan¹,

Yıldız²,

Demir

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Species within these genera metabolise lactate to the SCFAs propionate and acetate while producing hydrogen [ 136 ]. Whilst propionate has been hypothesised to have antidepressant effects, excess propionate has been associated with increased depressive-like behaviours in animal studies [ 137 ] and elevated levels of propionate have been reported in Alzheimer’s disease [ 138 ]. In addition, it has been hypothesised that a by-product of lactate metabolism—hydrogen—may also influence host physiology [ 130 , 139 ].…”

Section: Discussionmentioning

confidence: 99%

A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia

et al. 2022

View full text Add to dashboard Cite

The emerging understanding of gut microbiota as ‘metabolic machinery’ influencing many aspects of physiology has gained substantial attention in the field of psychiatry. This is largely due to the many overlapping pathophysiological mechanisms associated with both the potential functionality of the gut microbiota and the biological mechanisms thought to be underpinning mental disorders. In this systematic review, we synthesised the current literature investigating differences in gut microbiota composition in people with the major psychiatric disorders, major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SZ), compared to ‘healthy’ controls. We also explored gut microbiota composition across disorders in an attempt to elucidate potential commonalities in the microbial signatures associated with these mental disorders. Following the PRISMA guidelines, databases were searched from inception through to December 2021. We identified 44 studies (including a total of 2510 psychiatric cases and 2407 controls) that met inclusion criteria, of which 24 investigated gut microbiota composition in MDD, seven investigated gut microbiota composition in BD, and 15 investigated gut microbiota composition in SZ. Our syntheses provide no strong evidence for a difference in the number or distribution (α-diversity) of bacteria in those with a mental disorder compared to controls. However, studies were relatively consistent in reporting differences in overall community composition (β-diversity) in people with and without mental disorders. Our syntheses also identified specific bacterial taxa commonly associated with mental disorders, including lower levels of bacterial genera that produce short-chain fatty acids (e.g. butyrate), higher levels of lactic acid-producing bacteria, and higher levels of bacteria associated with glutamate and GABA metabolism. We also observed substantial heterogeneity across studies with regards to methodologies and reporting. Further prospective and experimental research using new tools and robust guidelines hold promise for improving our understanding of the role of the gut microbiota in mental and brain health and the development of interventions based on modification of gut microbiota.

show abstract

“…Skin microbiota members, specifically Actinobacteria , are known to be propionate producers. In addition, saliva, fecal, and hippocampus propionate levels have been found to increase significantly in Alzheimer’s disease patients ( 23 ). Our results also suggest a potential association between the increase in propionate biosynthesis by skin microbiota and CI stages in PD.…”

Section: Discussionmentioning

confidence: 99%

Axillary Microbiota Is Associated with Cognitive Impairment in Parkinson’s Disease Patients

et al. 2022

View full text Add to dashboard Cite

show abstract

Propionate and Alzheimer’s Disease

Cited by 42 publications

References 132 publications

Axillary Microbiota is Associated with Cognitive Impairment in Parkinson’s Disease Patients

Axillary Microbiota is Associated with Cognitive Impairment in Parkinson’s Disease Patients

A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia

Axillary Microbiota Is Associated with Cognitive Impairment in Parkinson’s Disease Patients

Contact Info

Product

Resources

About