Propionate Enhances Synthesis and Secretion of Bile Acids in Primary Cultured Rat Hepatocytes<i>via</i>Succinyl CoA

Imaizumi, Kazunori; Hirata, Keizaburo; Yasni, Sedarnawati; Sugano, Michihiro

doi:10.1271/bbb.56.1894

Cited by 21 publications

(14 citation statements)

References 8 publications

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“…The postulated mechanisms by which prebiotics decrease yolk cholesterol might be attributed to the production of short‐chain fatty acids (SCFA), upon fermentation by the probiotic organisms (Hara and others ) and the deconjugation and fecal excretion of bile acids due to the stimulation of growth of probiotics that occurs because prebiotics are the food sources of probiotics (Shang and others ). SCFA has been proposed to be able to suppress hepatic cholesterol synthesis (Hara and others ) and to stimulate bile acid synthesis (Imaizumi and others ). Synbiotics have been suggested to have the ability to alter the pathways of cholesteryl esters and lipoprotein transporters (Liong and others ), which might reduce the availability of cholesterol for deposition into egg yolks.…”

Section: Resultsmentioning

confidence: 99%

Chemical Compositions of Egg Yolks and Egg Quality of Laying Hens Fed Prebiotic, Probiotic, and Synbiotic Diets

Tang

Sieo

Ramasamy

et al. 2015

Journal of Food Science

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A 16-wk feeding experiment was conducted to investigate the effects of a prebiotic, isomaltooligosaccharide (IMO), a probiotic, PrimaLac®, and their combination as a synbiotic on the chemical compositions of egg yolks and the egg quality of laying hens. One hundred and sixty 16-wk-old Hisex Brown pullets were randomly assigned to 4 dietary treatments: (i) basal diet (control), (ii) basal diet + 1% IMO (PRE), (iii) basal diet + 0.1% PrimaLac® (PRO), and (iv) basal diet + 1% IMO + 0.1% PrimaLac® (SYN). PRE, PRO, or SYN supplementation not only significantly (P < 0.05) decreased the egg yolk cholesterol (24- and 28-wk-old) and total saturated fatty acids (SFA; 28-, 32-, and 36-wk-old), but also significantly (P < 0.05) increased total unsaturated fatty acids (UFA; 28-, 32-, and 36-wk-old), total omega 6 and polyunsaturated fatty acids (PUFA), including linoleic and alpha-linolenic acid levels in the eggs (28-wk-old). However, the total lipids, carotenoids, and tocopherols in the egg yolks were similar among all dietary treatments in the 24-, 28-, 32-, and 36-wk-old hens. Egg quality (Haugh unit, relative weights of the albumen and yolk, specific gravity, shell thickness, and yolk color) was not affected by PRE, PRO, or SYN supplementation. The results indicate that supplementations with IMO and PrimaLac® alone or in combination as a synbiotic might be useful for improving the cholesterol content and modifying the fatty acid compositions of egg yolk without affecting the quality of eggs from laying hens between 24 and 36 wk of age.

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Section: Resultsmentioning

confidence: 99%

Chemical Compositions of Egg Yolks and Egg Quality of Laying Hens Fed Prebiotic, Probiotic, and Synbiotic Diets

Tang

Sieo

Ramasamy

et al. 2015

Journal of Food Science

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“…24 ) GOS produced a significant hypocholesterolemic effect in the OVX rats. Imaizumi et al 25 ) have reported that propionic acid enhanced the in vitro synthesis and secretion of bile acids by hepatocytes via the elevation of its metabolite, succinyl CoA. Chen et al 7 ) also reported that feeding propionic acid to rats decreased the serum cholesterol level.…”

Section: Discussionmentioning

confidence: 99%

Effect of Galactooligosaccharides on Calcium Absorption and Preventing Bone Loss in Ovariectomized Rats

Chonan

Matsumoto

Watanuki

1995

Bioscience, Biotechnology, and Biochemistry

148

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“…The mechanism underlying the cholesterol lowering effects of SCFA such as propionate includes the inhibition of cholesterol synthesizing enzyme (3-hydroxy 3-methylglutaryl CoA reductase) and redistribution of cholesterol from the blood plasma to the liver (Wright et al, 1990;Arora et al, 2011). Propionate can also improve the secretion and synthesis of bile acids, and cholesterol 7a hydroxylase activity in primary cultured rat hepatocytes by increasing mitochondrial succinyl CoA concentrations (Imaizumi et al, 1992;Levrat et al, 1994). Furthermore, addition of propionate and butyrate to Caco-2 cell lines trigger downregulation of genes involved in the intestinal cholesterol synthesis pathway (Alvaro et al, 2008).…”

Section: Diabetes and Metabolic Syndrome Preventionmentioning

confidence: 99%

Prebiotics to Fight Diseases: Reality or Fiction?

Bartolomeo

Startek

Ende

2012

Phytotherapy Research

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Bacteria living in the gastrointestinal tract are crucial for human health and disease occurrence. Increasing the beneficial intestinal microflora by consumption of prebiotics, which are 'functional foods', could be an elegant way to limit the number and incidence of disorders and to recover from dysbiosis or antibiotic treatments. This review focuses on the short-chain low-digestible carbohydrates (LDCs) which are metabolized by gut microbiota serving as energy source, immune system enhancers or facilitators of mineral uptake. Intake of foods containing LDCs can improve the state of health and may prevent diseases as for example certain forms of cancer. Given the large number of different molecules belonging to LDCs, we focused our attention on fructans (inulin, fructo-oligosaccharides), galacto-oligosaccharides and resistant starches and their therapeutic and protective applications. Evidence is accumulating that LDCs can inhibit bacterial and viral infections by modulating host defense responses and by changing the interactions between pathogenic and beneficial bacteria. Animal studies and studies on small groups of human subjects suggest that LDCs might help to counteract colorectal cancer, diabetes and metabolic syndrome. The action mechanisms of LDCs in the human body might be broader than originally thought, perhaps also including reactive oxygen species scavenging and signaling events.

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Propionate Enhances Synthesis and Secretion of Bile Acids in Primary Cultured Rat HepatocytesviaSuccinyl CoA

Cited by 21 publications

References 8 publications

Chemical Compositions of Egg Yolks and Egg Quality of Laying Hens Fed Prebiotic, Probiotic, and Synbiotic Diets

Chemical Compositions of Egg Yolks and Egg Quality of Laying Hens Fed Prebiotic, Probiotic, and Synbiotic Diets

Effect of Galactooligosaccharides on Calcium Absorption and Preventing Bone Loss in Ovariectomized Rats

Prebiotics to Fight Diseases: Reality or Fiction?

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