Propionibacterium spp.—source of propionic acid, vitamin B12, and other metabolites important for the industry

Abstract

Bacteria from the Propionibacterium genus consists of two principal groups: cutaneous and classical. Cutaneous Propionibacterium are considered primary pathogens to humans, whereas classical Propionibacterium are widely used in the food and pharmaceutical industries. Bacteria from the Propionibacterium genus are capable of synthesizing numerous valuable compounds with a wide industrial usage. Biomass of the bacteria from the Propionibacterium genus constitutes sources of vitamins from the B group, including B12, trehalose, and numerous bacteriocins. These bacteria are also capable of synthesizing organic acids such as propionic acid and acetic acid. Because of GRAS status and their health-promoting characteristics, bacteria from the Propionibacterium genus and their metabolites (propionic acid, vitamin B12, and trehalose) are commonly used in the cosmetic, pharmaceutical, food, and other industries. They are also used as additives in fodders for livestock. In this review, we present the major species of Propionibacterium and their properties and provide an overview of their functions and applications. This review also presents current literature concerned with the possibilities of using Propionibacterium spp. to obtain valuable metabolites. It also presents the biosynthetic pathways as well as the impact of the genetic and environmental factors on the efficiency of their production.

Station and train surface microbiomes of Mexico City’s metro (subway/underground)

“…Interestingly Propionibacterium has been described in multiple environments, including soil, freshwater, marine, and host-associated, and while Corynebacterium has been described in these same environments, it has been more frequently found in marine environments 18 . Propionibacterium is divided into cutaneous and environmental strains, and some consider the cutaneous strain to be a primary human pathogen; it also has multiple biotechnological uses as a source of valuable metabolites like vitamin B12, trehalose, propionic acid, and bacteriocins, and some even propose its use as a probiotic 19 . We found a total of 2,341 OTUs classified as Propionibacterium, with 1,358 OTUs best matching P. acnes and P. granulosum (105 OTUs), as well as 878 unknown Propionibacterium species.…”

Endophytic Bacterial Microbiome Diversity in Early Developmental Stage Plant Tissues of Wheat Varieties

“…In general, an inhibitory effect on the Propionibacterium sp. is produced by high acidity, high salt concentrations, extreme temperatures and, last but not least, insufficient water activity [42]. The environment with the highest addition of PEG 6000 (10%) cannot be characterized as an extreme one, as the concentration can be further increased and the spectrum of bacterial populations can expand, but even under such conditions the bacteria species are in a condition where their activity is limited by residual humidity.…”

Machine learning pattern recognition and differential network analysis of gastric microbiome in the presence of proton pump inhibitor treatment orHelicobacter pyloriinfection

“…In particular, one species, Acinetobacter lwoffi , can trigger gastritis, apart from H. pylori 121 . Propionibacterium, so named for their unique ability to synthesize propionic acid by using unusual transcarboxylase enzymes 122 , are primarily facultative pathogens and commensals of humans, living on the skin, while other members are widely employed for synthetizing vitamin B 12 , tetrapyrrole compounds, and propionic acid, as well as used as probiotics 123 . Catonella is another node in the network and this bacterial genus is obligative anaerobic, non-spore-forming and non-motile, with one known species ( Catonella morbi ) from the human gingival crevice 124,125 , that has been associated with periodontitis 124 and endocarditis 126 .…”