Propionyl-l-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model

Al-Majed, Abdulhakeem A.; Sayed‐Ahmed, Mohamed M.; Al-Yahya, Abdulaziz A.; Aleisa, Abdulaziz M.; Al-Rejaie, Salim S.; Al‐Shabanah, Othman A.

doi:10.1016/j.phrs.2005.12.005

Cited by 94 publications

(88 citation statements)

References 47 publications

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“…Treatment with L-carnitine before the CDDP challenge could significantly prevent the depletion of the kidney and liver antioxidant systems. Similar results have been reported by Aleisa et al [14], Al-Majed et al [15], and Arafa HM [41] for kidney and liver tissues in which cisplatin and carboplatin injections caused low GSH, GSH-Px, SOD, and nitric oxide levels. Furthermore, in this study, it was observed that levels of GSH-Px and SOD for CDDP in the L-carnitine-treated groups were higher than in the CDDP group.…”

Section: Discussionsupporting

confidence: 88%

“…In fact, carnitine effectively inhibits mitochondrial damage induced by oxidative stress, as well as mitochondriadependent apoptosis in various types of cells [13,14]. The effects of LC on the metabolism of tissues in organs such as the heart [15], brain [16], and liver [13] have been studied widely. Current reports suggest that LC may play a significant role in balancing antioxidative systems and has an antiperoxidative effect on some tissues [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

et al. 2009

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AbstractThe present study was designed to investigate the protective effects of L-carnitine (LC) on changes in the levels of lipid peroxidation and endogenous antioxidants induced by cisplatin (cis-diamminedichloroplatinum II, CDDP) in the liver and kidney tissues of rats. Twenty-four Sprague Dawley rats were equally divided into four groups of six rats each: control, cisplatin, L-carnitine, and L-carnitine plus cisplatin. The degree of protection produced by L-carnitine was evaluated by determining the level of malondialdehyde (MDA). The activity of glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), and superoxide dismutase (SOD) were estimated from liver and kidney homogenates, and the liver and kidney were histologically examined as well. L-carnitine elicited significant liver and kidney protective activity by decreasing the level of lipid peroxidation (MDA) and elevating the activity of GSH, GSHPx, GST, and SOD. Furthermore, these biochemical observations were supported by histological findings. In conclusion, the present study indicates a significant role for reactive oxygen species (ROS) and their relation to liver and kidney dysfunction, and points to the therapeutic potential of LC in CDDP-induced liver and kidney toxicity.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

et al. 2009

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“…The antioxidants can play in protecting against CISinduced toxicity in mammalian systems [44,45]. However, little is known about the interaction of antitumor drugs with antioxidants [46]. The results of the estimation of serum biochemical markers and endogenous enzymatic and non-enzymatic antioxidants data clearly revealed that NJ and DNG significantly reduced the nephrotoxic effect induced by CIS which is confirmed by histopathological study.…”

Section: Discussionmentioning

confidence: 69%

Chemoprotective Effect of Noni (Morinda Citrifolia L.) Fruit Juice Against Cisplatin-Induced Nephrotoxicity

Ali

Mruthunjaya

Nandini

et al. 2016

Int J Pharm Pharm Sci

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Objective: Cisplatin (CIS) consumption has become a common problem that affects the health of patients around the globe. Kidney has been suspected to be particularly susceptible to the destructive effects of CIS and nephrotoxic effects are still contentious which in turn affects the Quality of Life (QoL) of patients and increase the mortality rate. This study was conducted to investigate the nephroprotective effect of Noni Juice (NJ) and Divine Noni Gold (DNG) as herbal medicine with established antioxidant properties against the controversial nephrotoxic effect of CIS in mice. Methods:Mice were divided into four groups, each group contained six mice. Group I was kept as normal, Group II received CIS (5.0 mg/kg b. wt. i. p.) on day one for 14 d. Group III and IV received NJ (0.35 ml/mouse p. o.) and DNG (0.35 ml/mouse p. o.) respectively once daily for 14 d, Group V received CIS (5.0 mg/kg b. wt. i. p.) on day one and NJ (0.35 ml/mouse p. o.) once daily for 14 d. Similarly, Group VI received CIS (5.0 mg/kg b. wt. i. p.) on day one and DNG (0.35 ml/mouse p. o.) once daily for 14 d. On day 15 blood from all the mice was collected from the carotid vein and cardiac puncture routes, and the biochemical markers viz. lactate dehydrogenase (LDH), creatinine phosphokinase (CPK), and urea were assessed. Kidney from all the animals was isolated, and catalase (CAT), glutathione (GSH), superoxide dismutase (SOD), thiols and lipid peroxidase (LPO) were estimated.Results: CIS-induced marked kidney injury; congestion of tubules, glomerular distortion foci, thickened and blocked blood vessels. Also showed significant elevation of LDH, CPK, and urea with significant inhibition of CAT, GSH, SOD, thiols activities and simultaneously elevation of LPO level. Co-administration of NJ and DNG respectively with CIS protected kidney tissues via oxidative stress inhibition.Conclusion: NJ and DNG possess protective effect against CIS-induced cellular damage in the kidney by decreasing the level of serum biochemical markers, enhancing the level of enzymatic and non-enzymatic antioxidants and maintaining the LPO level. Results suggest that NJ and DNG have strong nephroprotective effect against CIS-induced nephrotoxicity.

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“…Cardiotoxicity may be an early or late complication after treatment with cisplatin. Acute manifestations are accompanied with electrocardiographic changes and arrhythmias, while late complications are primarily associated with the development of cardiomiopathy and congestive heart failure (12)(13)(14). Experimental evidence supports the hypothesis that cisplatin and its analogues promote cardiotoxicity through the formation of reactive oxygen species (ROS), such as superoxide anion radical (O 2 -.…”

Section: Introductionmentioning

confidence: 94%

The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart

Radonjić

Milosavljevic

Živković

et al. 2017

Serbian Journal of Experimental and Clinical Research

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Propionyl-l-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model

Cited by 94 publications

References 47 publications

Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

Chemoprotective Effect of Noni (Morinda Citrifolia L.) Fruit Juice Against Cisplatin-Induced Nephrotoxicity

The Platinum(II) Complexes Induced Oxidative Stress of Isolated Rat Heart

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