Propofol and Postoperative Pain: Systematic Review and Meta-Analysis

Effects of intra‐operative maintenance of general anaesthesia with propofol on postoperative pain outcomes – a systematic review and meta‐analysis

“…This finding suggests that propofol may act on receptors inside the cell membrane, or hydrophobic regions of the cell, due to the intrinsic hydrophobic properties of propofol [38]. There are novel findings in this meta-analysis, which cannot be compared with results from the meta-analysis of Hasani et al, not only because of the heterogeneous population in the latter but also because they divided patients using a binary split of 'risk of postoperative pain', as opposed to 'no risk of postoperative pain', rather than using pain scores as we have done [12]. They concluded that propofol could reduce postoperative pain, but the effect size was small and further studies were required to confirm the findings.…”

“…A previous meta-analysis exploring the analgesic efficacy of propofol concluded that propofol might improve postoperative analgesia compared with other anaesthetics, including isoflurane and thiopentone, and that its use was associated with fewer adverse effects [12]. However, this meta-analysis included studies both of patients with postoperative pain and of healthy volunteers.…”

Opioid use after propofol or sevoflurane anesthesia: a randomized trial

“…Superiority was not found for postoperative morphine equivalents and overall pain score propofol was 0.33 to 2.45. The observed median [IQR] morphine sulfate equivalents were 9.8 [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] mg for sevoflurane and 10 [6-20] mg for propofol.…”

“…For the initial four postoperative hours and on the first postoperative morning, a blinded investigator recorded pain scores on an 11-point Likert verbal response scale. Results The median [interquartile range] morphine sulfate equivalents were 9.8 [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] mg in the sevoflurane group and 10 [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] mg in the propofol group. Sevoflurane was not superior to propofol on postoperative opioid consumption, giving a ratio of means of 0.91 (95% interimadjusted confidence interval [CI], 0.33 to 2.45; P = 0.74).…”

“…C'est pourquoi nous avons testé l'hypothèse selon laquelle les patients anesthésiés avec du sévoflurane nécessiteraient une quantité plus importante d'opioïdes en période postopératoire (de la fin de la chirurgie jusqu'au premier matin postopératoire) que les patients anesthésiés avec du propofol. Méthode Ayant reçu l'approbation d ' [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] mg dans le groupe propofol. Le sévoflurane ne s'est pas avéré supérieur au propofol en ce qui touchait à la consommation d'opioïdes en période postopératoire, avec un rapport de moyennes de 0,91 (intervalle de confiance [IC] provisoire ajusté 95 %, 0,33 à 2,4; P = 0,74).…”