Propofol at Single Bolus and Continuous Rate Infusion Significantly Increases Serum Triglycerides, but not Cholesterol, In Healthy Bitches Undergoing Elective Ovariohysterectomy

Chagas, M S; Custodio, LP; Gusmão, BS; COSTA, IM; Julião, GH; Bordolini, Sls; Costa, LR; Bosculo, Mrm; Moreira, TF; Almeida, Bfm; Filho, NP Reis; Romão, FG; Abimussi, Caio José Xavier; Floriano, BP

doi:10.1016/j.tcam.2021.100560

Cited by 3 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, hepatic TG synthesis decreases by 50% in rats during oophorectomy [ 64 ]. Conversely, Bilen [ 65 ] and Chagas et al [ 66 ] showed an increase in TG in dogs after OHE without modifications in CHOL. This elevation of TG is considered a physiological and transient condition that decreases at 7–12 h and could be due to food restriction prior to surgery.…”

Section: Discussionmentioning

confidence: 98%

Changes in Hematological and Biochemical Profiles in Ovariohysterectomized Bitches Using an Alfaxalone–Midazolam–Morphine–Sevoflurane Protocol

Rubio

Satué

Carrillo

et al. 2022

Animals

View full text Add to dashboard Cite

The aim of this study was to monitor hematochemical changes during and after OHE in bitches. Twenty-four females were anesthetized with alfaxalone, midazolam, morphine and sevoflurane. Blood samples were taken before anesthesia (T0), at 30 (T1), and 60 min (T2), at 3 (T3), 6 (T4), 12 (T5), and 24 h (T6), and at 3 (T7) and 7 days (T8) from the start of surgery. Red blood cells (RBC) and packed cell volume (PCV) decreased significantly from T1 to T5 and hemoglobin (HB) concentration from T4 to T6. Both the white blood cell (WBC) and neutrophil (NFS) count increased significantly from T3 to T6, monocyte (MON) from T2 to T5, and eosinophil (EOS) at T5. Platelet (PLT) and plateletcrit (PCT) significantly decreased at T5 and increased from T6 to T8; platelet distribution width (PDW) increased significantly from T3 to T6. Creatine kinase (CK) activity increased significantly from T5 to T7. Glucose (GLU) concentrations increased significantly at T2 and P from T2 to T3. TG levels decreased from T2 to T4 and blood urea nitrogen (BUN) levels from T1 to T7, subsequently increasing until T8. Changes possibly resulting from stress and surgical trauma, as well as hemodilution and splenic storage, are due to anesthesia and surgery. In healthy bitches, these changes tend to gradually stabilize after the ending of OHE. A post-operative follow-up is essential to detect possible post-operative complications.

show abstract

Section: Discussionmentioning

confidence: 98%

Changes in Hematological and Biochemical Profiles in Ovariohysterectomized Bitches Using an Alfaxalone–Midazolam–Morphine–Sevoflurane Protocol

Rubio

Satué

Carrillo

et al. 2022

Animals

View full text Add to dashboard Cite

show abstract

“…The mechanism of propofol‐induced pancreatitis is not fully understood, although propofol‐induced hypertriglyceridemia or idiosyncratic drug reaction is suspected 23 . Chagas et al 24 . showed recently that even a single bolus of propofol for induction increased serum triglycerides significantly and caused lipaemia in healthy dogs.…”

Section: Discussionmentioning

confidence: 99%

Partial intravenous anaesthesia and opioid‐sparing analgesia in a dog undergoing surgical management of insulinoma

Gavet

Ruiz

2022

Vet Record Case Reports

View full text Add to dashboard Cite

A 4.5-year-old dog was anaesthetised to undergo a partial pancreatectomy for insulinoma removal, an insulin-secreting pancreatic tumour causing hypoglycaemia. The patient was premedicated with dexmedetomidine (2 μg/kg) and maropitant (1 mg/kg) intravenously. Anaesthesia was induced with alfaxalone (0.5 mg/kg) and diazepam (0.2 mg/kg) intravenously and maintained with a dexmedetomidine constant-rate infusion of 1 μg/kg/h and isoflurane in 70% oxygen. A bilateral transversus abdominis plane block was performed with ropivacaine (0.3% 1 ml/kg) divided into four points. Additional intraoperative analgesia included ketamine, fentanyl and methadone intravenously. Lactated Ringer's solution was administered, and glucose supplementation was adjusted based on glycaemia. Postoperatively, the patient was comfortable and required no analgesia for the 48-hour hospitalisation period, but presented mild hyperglycaemia. This case reports the successful management of an insulinoma with a dexmedetomidine constant-rate infusion and opioid-sparing multimodal analgesia.

show abstract

High carbohydrate is preferable to high lipid parenteral nutrition in healthy dogs undergoing prolonged sedation

Regalin,

de Moraes,

Adorno

et al. 2024

Vet Res Commun

View full text Add to dashboard Cite

Propofol at Single Bolus and Continuous Rate Infusion Significantly Increases Serum Triglycerides, but not Cholesterol, In Healthy Bitches Undergoing Elective Ovariohysterectomy

Cited by 3 publications

References 16 publications

Changes in Hematological and Biochemical Profiles in Ovariohysterectomized Bitches Using an Alfaxalone–Midazolam–Morphine–Sevoflurane Protocol

Changes in Hematological and Biochemical Profiles in Ovariohysterectomized Bitches Using an Alfaxalone–Midazolam–Morphine–Sevoflurane Protocol

Partial intravenous anaesthesia and opioid‐sparing analgesia in a dog undergoing surgical management of insulinoma

High carbohydrate is preferable to high lipid parenteral nutrition in healthy dogs undergoing prolonged sedation

Contact Info

Product

Resources

About