Propofol in patients with cardiac disease

Searle, Norman R.; Sahab, P.

doi:10.1007/bf03009770

Cited by 71 publications

(44 citation statements)

References 124 publications

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“…It has many advantages over older medications such as its onset, duration and recovery time, maintenance of anesthesia as well as its anti-emetic property. However, the possible serious side effect of drop in blood pressure is still noted in daily anesthesia practice with propofol 6,7 .…”

Section: Discussionmentioning

confidence: 99%

Efeito da administração de solução salina na estabilidade da circulação durante a indução de anestesia geral com propofol em estudo randômico e controlado de procedimentos ginecológicos

Rabadi¹

2013

Rev. Bras. Anestesiol.

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Background and objective: To compare the effect of prophylactic administration of normal saline against the hypotensive effect of propofol in female patients booked for gynecological procedures. Method: Sixty nine ASA (I, II) patients were randomly allocated into two groups, group 1 received 5 mL.kg -1 of 0.9% normal saline 10 minutes before induction, whereas group 2 received nothing (control). Anesthesia was induced with propofol and fentanyl then maintained with propofol and remifentanil. We measured hemodynamic variables pre and post general anesthesia induction. Results: Both groups had signifi cant drops in post induction mean arterial blood pressure (P < 0.001). Also both groups had signifi cant drops in post induction heart rate ((P < 0.02 in sample group and P < 0.001 in control group), and 35% of patients in the control group had more than 25% drop in the pre induction mean arterial blood pressure, compared with only 17% of patients in the saline group (P < 0.04). Conclusion: The prophylactic administration of normal saline could decrease the percentage of patients who had a signifi cant drop in their blood pressure after propofol induction of general anesthesia.

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Section: Discussionmentioning

confidence: 99%

Efeito da administração de solução salina na estabilidade da circulação durante a indução de anestesia geral com propofol em estudo randômico e controlado de procedimentos ginecológicos

Rabadi¹

2013

Rev. Bras. Anestesiol.

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“…However, there are important questions regarding the narrow therapeutic range, and propofol can only be used by anesthetists (7). With respect to the potential side effects of propofol, one should beware of respiratory depression and the risk of hypotension (8,9). However, the sedative and amnestic effects of benzodiazepines sometimes do not provide adequate patient comfort during colonoscopic procedures.…”

Section: Discussionmentioning

confidence: 99%

Sedation with midazolam versus midazolam plus meperidine for routine colonoscopy: A prospective, randomized, controlled study

Çınar

Yakut²,

Özden

2009

Turk J Gastroenterol

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“…It has a pKa of 11, is highly fat soluble, dissolves poorly in water, and binds 99% to proteins. It is dissolved in Intralipid, a 1% emulsion containing 10% soya oil, 2.25% glycerol and 1.2% purified egg phosphatide as a stabilizer (Doyle, 1998;Searle & Sahab, 1993). Propofol is rapidly metabolized with less than 20% recovered unchanged after 30 minutes (Peskin, 1992).…”

Section: Problem Of Reducing Costsmentioning

confidence: 99%

“…Propofol is rapidly metabolized with less than 20% recovered unchanged after 30 minutes (Peskin, 1992). It has a distribution half life (t (Doyle, 1998;Searle & Sahab, 1993). Suggested induction dose is 2.5 mg/kg, with onset at 22-125 seconds after injection.…”

Section: Problem Of Reducing Costsmentioning

confidence: 99%

“…There is a slight risk for anaphylaxis with patients allergic to eggs due to the lecithin used as a stabilizer. This risk is probably minimal as most patients are allergic to egg protein or albumin and not lecithin, but prudence indicates caution until more information is available (Searle & Sahab, 1993). Patients receiving propofol had significantly more dreams versus thiopental, but the content was similar (Brandner, Blagrove, McCallum, & Bromley, 1997).…”

Section: Problem Of Reducing Costsmentioning

confidence: 99%

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Comparison Of The Direct Costs, Length Of Recovery, And Incidence Of Post Operative Anti Emetic Use After Anesthesia Induction With Propofol Or A 1:1 Mixture Of Thiopental And Propofol

Killpack¹

1999

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Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. The modern anesthesia provider must consider drug costs as important as benefits and risks when choosing which drug to use in an anesthetic. Thiopental has been the gold standard for an IV induction drug although propofol shows a better recovery profile with less post-operative nausea and vomiting, but at a higher cost. We attempted to determine if a 1:1 volume mixture of thiopental and propofol would show a similar recovery profile compared to propofol alone, but at a lower cost. This study examined the records of 212 surgery patients receiving propofol (n=82) or a 1:1 mixture (n=130) for demographic, peri-operative, PACU recovery, anti-emetic use, and cost data. We found that the propofol group had significantly more females, postoperative anti-emetic use, and induction drug costs, while the 1:1 mixture group had significantly longer surgery and anesthesia times. Mean post-operative anti-emetic drug costs were statistically significant (P<0.05) at $3.15 for the propofol group and $1.08 for the 1:1 mixture group. The mean cost of induction for the propofol group was $27.31 and $14.31 for the 1:1 mixture group, a statistically significant (P<0.05) difference of $13.09. The average recovery time for the propofol group was 134 minutes and cost $1205.37, and for the 1:1 mixture group 147 minutes and cost $1320.03. Thus, the difference in PACU charges was $114.66. This research suggests that the 1:1 mixture of thiopental and propofol produced a similar recovery profile to propofol alone, but at a lower direct cost. This study supported previous work, and recommends that further research be done to confirm its findings. ix ACKNOWLEDGEMENT SUBJECT TERMS

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Propofol in patients with cardiac disease

Abstract: Propofol is an intravenous anaesthetic which is chemically un

Cited by 71 publications

References 124 publications

Efeito da administração de solução salina na estabilidade da circulação durante a indução de anestesia geral com propofol em estudo randômico e controlado de procedimentos ginecológicos

Efeito da administração de solução salina na estabilidade da circulação durante a indução de anestesia geral com propofol em estudo randômico e controlado de procedimentos ginecológicos

Sedation with midazolam versus midazolam plus meperidine for routine colonoscopy: A prospective, randomized, controlled study

Comparison Of The Direct Costs, Length Of Recovery, And Incidence Of Post Operative Anti Emetic Use After Anesthesia Induction With Propofol Or A 1:1 Mixture Of Thiopental And Propofol

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