Propofol Total Intravenous Anesthesia as an Intervention for Severe Radiation-Induced Phantosmia in an Adolescent with Ependymoma

Raghavan, Kalyani; Camfield, Angela S; Lucas, John T.; Ismael, Yousef; Rossi, Michael; Anghelescu, Doralina L.

doi:10.1089/jayao.2019.0103

Cited by 3 publications

(8 citation statements)

References 8 publications

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“…Currently, there is no standardized treatment strategy for patients developing radiation-induced olfactory toxicity. A recent study by Raghavan et al 12 described the use of propofol total intravenous anesthesia as a treatment for severe radiation-induced phantosmia. The patient described in the report was a 16-year-old girl diagnosed with myxopapillary ependymoma treated with proton therapy treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Other potential interventions for radiation-induced phantosmia that have not yet been studied but were described in the literature on the management of nonradiation-induced olfactory disorders include topical cocaine; propofol in subanesthetic antiemetic doses; antipsychotic, antimigraine, and antiepileptic medications; and magnetic stimulation. 2 , 12 Prospective studies are needed to identify both effective and safe interventions that will constitute a standard practice for treating patients suffering from radiation-induced phantosmia.…”

Section: Discussionmentioning

confidence: 99%

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Phantosmia Among Pediatric, Adolescent, and Young Adult Patients Receiving Proton Beam Therapy

Rosenzweig

Lazarev

Hasan

et al. 2022

Advances in Radiation Oncology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Phantosmia Among Pediatric, Adolescent, and Young Adult Patients Receiving Proton Beam Therapy

Rosenzweig

Lazarev

Hasan

et al. 2022

Advances in Radiation Oncology

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“…On May 31, 2022, a PubMed search using the terms “radi*” AND (“olfaction” OR “odor” OR “smell” OR “phantosmia”) was performed, revealing 2765 studies; among these, only 9 studies were based on this sensation. 1 , 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 Three other related reports were identified based on the references in these articles. 11 , 12 , 13 Table 1 presents the details of these studies.…”

Section: Methodsmentioning

confidence: 99%

“…Among these, 2 were prospective observational studies, 2 , 10 2 were retrospective chart reviews, 4 , 9 and 2 were case reports. 6 , 11 …”

Section: Methodsmentioning

confidence: 99%

“…Preventing this perception is occasionally necessary in pediatric patients, such as by using essential oils, 1 , 4 and certain patients may not be able to continue the session without sedation or anesthesia. 1 , 5 , 6 To better characterize the occurrence of the sensation of smell during radiation treatment and draw attention to this unusual phenomenon, this study reviews the unusual smells experienced during radiation sessions, focusing on related literature, phenomenon frequency, and possible causes.…”

Section: Introductionmentioning

confidence: 99%

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Olfactory Sensations During Radiation Sessions: A Review

Sasai¹

2023

Advances in Radiation Oncology

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Proton Radiation Therapy: A Systematic Review of Treatment-Related Side Effects and Toxicities

Salem,

Chami,

Daou

et al. 2024

IJMS

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Cancer is the second leading cause of death worldwide. Around half of all cancer patients undergo some type of radiation therapy throughout the course of their treatment. Photon radiation remains (RT) the most widely utilized modality of radiotherapy despite recent advancements in proton radiation therapy (PBT). PBT makes use of the particle’s biological property known as the Bragg peak to better spare healthy tissue from radiation damage, with data to support that this treatment modality is less toxic than photon RT. Hence, proton radiation dosimetry looks better compared to photon dosimetry; however, due to proton-specific uncertainties, unexpected acute, subacute, and long-term toxicities can be encountered. Reported neurotoxicity resulting from proton radiation treatments include radiation necrosis, moyamoya syndrome, neurosensory toxicities, brain edema, neuromuscular toxicities, and neurocognitive toxicities. Pulmonary toxicities include pneumonitis and fibrosis, pleural effusions, and bronchial toxicities. Pericarditis, pericardial effusions, and atrial fibrillations are among the cardiac toxicities related to proton therapy. Gastrointestinal and hematological toxicities are also found in the literature. Genitourinary toxicities include urinary and reproductive-related toxicities. Osteological, oral, endocrine, and skin toxicities have also been reported. The side effects will be comparable to the ones following photon RT, nonetheless at an expected lower incidence. The toxicities collected mainly from case reports and clinical trials are described based on the organs affected and functions altered.

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Propofol Total Intravenous Anesthesia as an Intervention for Severe Radiation-Induced Phantosmia in an Adolescent with Ependymoma

Cited by 3 publications

References 8 publications

Phantosmia Among Pediatric, Adolescent, and Young Adult Patients Receiving Proton Beam Therapy

Phantosmia Among Pediatric, Adolescent, and Young Adult Patients Receiving Proton Beam Therapy

Olfactory Sensations During Radiation Sessions: A Review

Proton Radiation Therapy: A Systematic Review of Treatment-Related Side Effects and Toxicities

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