Proposal and Validation of a Quick Question to Rate the Influence of Diet in Geriatric Epidemiological Studies on Vitamin D

Chevallereau, Gaëlle; Gleyses, Xavier; Roussel, L.; Hamdan, Sarah; Beauchet, Olivier; Annweiler, Cédric

doi:10.1024/0300-9831/a000163

Cited by 8 publications

(4 citation statements)

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“…20e28 None of them used ANN methods, but used conventional linear statistical methods. Specifically, the few previous studies in this area tested the performance of already existing dietary questionnaires, 22,23,25 general physical questionnaires, 27,28 or isolated questions 24,26 to detect hypovitaminosis D. Whatever the model tested, results showed rather good sensitivity to hypovitaminosis D (range, 46%e91%) 27,28 but only modest specificity (range, 35%e74%), 25,29 and each time only a single metrological quality was observed (either sensitive or specific). Thus, the results of the current study provide new insights into the identification of hypovitaminosis D in seniors by using a novel statistical approach and by exhibiting greater diagnostic efficiency than hitherto.…”

Section: Discussionmentioning

confidence: 86%

Derivation and Validation of a Clinical Diagnostic Tool for the Identification of Older Community-Dwellers With Hypovitaminosis D

Annweiler

Kabeshova

Legeay

et al. 2015

Journal of the American Medical Directors Association

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Section: Discussionmentioning

confidence: 86%

Derivation and Validation of a Clinical Diagnostic Tool for the Identification of Older Community-Dwellers With Hypovitaminosis D

Annweiler

Kabeshova

Legeay

et al. 2015

Journal of the American Medical Directors Association

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“…Although numerous studies have examined the variables influencing serum 25(OH)D concentration, only few have attempted to identify hypovitaminosis D among older adults, and only two among geriatric patients [ 18 , 19 ]. Specifically, these two previous studies have tested the performance of an isolated question [ 18 ] or a general physical questionnaire [ 19 ] to detect hypovitaminosis D among in- and outpatients; but none has evaluated the different definitions of hypovitaminosis D, and none have used a complex algorithm based on non-linear models of feed forward artificial neural networks such as the VDSP [ 8 ]. Thus, the results of the present study provide new insights into the identification of hypovitaminosis D in geriatric patients by using a novel clinical tool, and by exhibiting greater diagnostic efficacy than that hitherto demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Clinical Identification of Geriatric Patients with Hypovitaminosis D: The ‘Vitamin D Status Predictor for Geriatrics’ Study

et al. 2017

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The 16-item Vitamin D Status Predictor (VDSP) tool identifies healthy older community-dwellers at risk of hypovitaminosis D and may guide the use of blood tests in this population. The objective of the present hospital-based study was to test the efficacy of the VDSP to identify geriatric patients with hypovitaminosis D. The study included 199 nonsupplemented geriatric in- and outpatients consecutively admitted to Angers University Hospital, France (mean ± SD, 82.0 ± 7.8 years; 53.3% female). Serum 25-hydroxyvitaminD (25(OH)D) was measured at the time of the physician-administered VDSP. Hypovitaminosis D was defined as serum 25(OH)D concentration ≤ 75 nmol/L for vitamin D insufficiency, 25(OH)D ≤ 50 nmol/L for vitamin D deficiency, and 25(OH)D ≤ 25 nmol/L for severe vitamin D deficiency. We found that 184 participants (92.4%) had vitamin D insufficiency, 136 (68.3%) had vitamin D deficiency, and 67 (33.7%) had severe vitamin D deficiency. The VDSP identified severe vitamin D deficiency with an area under curve (AUC) = 0.83 and OR = 24.0. The VDSP was able to identify vitamin D deficiency and vitamin D insufficiency with less accuracy (AUC = 0.71 and AUC = 0.73, respectively). In conclusion, the 16-item VDSP is a short questionnaire that accurately identifies geriatric patients with severe vitamin D deficiency. This tool may guide the use of blood collection for determining geriatric patients’ vitamin D status.

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“…, answer “No”) or adequate ( i.e. , answer “Yes”), as previously published [ 18 ]. Finally, the serum concentrations of TSH, vitamin B12, albumin and creatinine were measured using automated standard laboratory methods at the University Hospital of Angers, France, and eGFR was calculated using the Cockcroft-Gault formula (((140 – age years ) × weight kg /creatinine µmol/L ) × 1.04 for females, and ×1.25 for males).…”

Section: Methodsmentioning

confidence: 99%

Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study

et al. 2015

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Our objective was to determine whether dietary vitamin K intake was associated with cognition and behavior among older adults. 192 consecutive participants ≥65 years, recruited in the cross-sectional CLIP (Cognition and LIPophilic vitamins) study, were separated into two groups according to the tertiles of dietary phylloquinone intake (i.e., lowest third below 207 µg/day versus the other two thirds combined). Daily dietary phylloquinone intake was estimated from 50-item interviewer-administered food frequency questionnaire. Cognition was assessed with Mini-Mental State Examination (MMSE); behaviour with Frontotemporal Behavioral Rating Scale (FBRS). Age, gender, social problems, education, body mass index (BMI), comorbidities, history of stroke, use vitamin K antagonists, inadequate fatty fish intake, serum thyroid-stimulating hormone (TSH), vitamin B12, albumin, and estimated glomerular filtration rate were used as confounders. Compared to participants in the lowest third of dietary phylloquinone intake (n = 64), those with higher intake had higher (i.e., better) mean MMSE score (22.0 ± 5.7 versus 19.9 ± 6.2, p = 0.024) and lower (i.e., better) FBRS score (1.5 ± 1.2 versus 1.9 ± 1.3, p = 0.042). In multivariate linear regressions, log dietary phylloquinone intake was positively associated with MMSE score (adjusted β = 1.66, p = 0.013) and inversely associated with FBRS score (adjusted β = −0.33, p = 0.037). Specifically, log dietary phylloquinone intake correlated negatively with FBRS subscore of physical neglect (r = −0.24, p = 0.001). Higher dietary phylloquinone intake was associated with better cognition and behavior among older adults.

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Proposal and Validation of a Quick Question to Rate the Influence of Diet in Geriatric Epidemiological Studies on Vitamin D

Abstract: A simple dietary question may identify older patients with hypovitaminosis D who should receive vitamin D supplements.

Cited by 8 publications

References 0 publications

Derivation and Validation of a Clinical Diagnostic Tool for the Identification of Older Community-Dwellers With Hypovitaminosis D

Derivation and Validation of a Clinical Diagnostic Tool for the Identification of Older Community-Dwellers With Hypovitaminosis D

Clinical Identification of Geriatric Patients with Hypovitaminosis D: The ‘Vitamin D Status Predictor for Geriatrics’ Study

Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study

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