Proposal of a health gut microbiome index based on a meta-analysis of Korean and global population datasets

Oh, Hyun-Seok; Min, Ui-Gi; Jang, Hye-Jin; Kim, Namil; Lim, Jeongmin; Chalita, Mauricio; Chun, Jongsik

doi:10.1007/s12275-022-1526-0

Cited by 10 publications

(15 citation statements)

References 114 publications

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“…Exploratory analysis of the fecal microbiome was performed using the gut microbiome index (GMI). 23 The index quantifies the similarity of the microbiome profile to that of healthy Koreans and represents the probability of being a "healthy" microbiome state. Details on the index were described in another article.…”

Section: Discussionmentioning

confidence: 99%

“…Exploratory fecal microbiome assessment was performed in subjects who agreed to give stool samples using validated stool collection kits (Gut Inside, CJBioscience). 22,23 Stool collection kits were delivered directly to the subjects by the central laboratory through a courier. The participants used a sterile spoon from the kit to collect the stool sample, and the stool was mixed with reagents in the sample tube.…”

Section: Methodsmentioning

confidence: 99%

“…Detailed procedures for fecal microbiome analysis were described elsewhere. 23 After completing the study schedule, subjects submitted the patient experience questionnaire regarding participation in a DCT in an anonymous manner. Subjects could freely comment on the positive and negative aspects of DCT based on their experience (Figure 1, Figure S2).…”

Section: Methodsmentioning

confidence: 99%

“…Exploratory fecal microbiome assessment was performed in subjects who agreed to give stool samples using validated stool collection kits (Gut Inside, CJBioscience) 22,23 . Stool collection kits were delivered directly to the subjects by the central laboratory through a courier.…”

Section: Methodsmentioning

confidence: 99%

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Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms

Huh,

Chung,

Park

et al. 2023

Clinical Translational Sci

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Decentralized clinical trials (DCTs) leverage digital technologies to reduce dependency on study sites and intermediaries. DCT should be balanced with accessibility and data reliability while meeting regulatory requirements. Here, we conducted a pilot study for functional constipation symptoms to investigate the feasibility of DCT. The study was an open, fully remote, randomized clinical trial in participants who had functional constipation symptoms. Electronic consent was obtained remotely, and study volunteers were screened through web‐based questionnaires. Subjects were randomized to either receive Lactobacillus and vitamin C supplements or vitamin C alone in a 1:1 ratio, which were delivered directly to subjects. Subjects kept track of bowel diaries daily during the 1‐week baseline and 2‐week treatment period using mobile applications. Bowel symptoms and the validity of the records were descriptively evaluated. A total of 30 subjects were randomized and completed the study. A total of 26.7% of subjects resided outside of the metropolitan area. Two‐week Lactobacillus treatments increased the number of defecations (+0.80 vs. +0.46 times per week) and decreased the defecation time (‐3.94 h vs. ‐1.62 h) compared to the comparator group. Overall, 67.1% of bowel diary records were completed in accordance with the schedule while 32.9% were not. Implementation of DCTs can facilitate geographic accessibility but should be guaranteed for data reliability. Prompt detection of errors and response using objective metrics would be required.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms

Huh,

Chung,

Park

et al. 2023

Clinical Translational Sci

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“…The characterization of population distribution according to the three enterotype classifications showed that the distributions of Enterotype 2 and Enterotype 1 differed by region. Samples from the U.S. and Japan had large numbers of Enterotype 1, while samples from Amazon natives in Venezuela, as well as from Malawi and Tanzania in Africa had large numbers of Enterotype 2 (Oh et al, 2022 ). In the present study, linear discriminant analysis (LDA) using LEfSe showed that Shantou, Guangzhou, and Meizhou belonged to Enterotype 1, Enterotype 2, and Enterotype 3, which were mainly composed of Bacteroides, Prevotella, and Blautia, respectively.…”

Section: Discussionmentioning

confidence: 99%

Fecal microbial signatures of healthy Han individuals from three bio-geographical zones in Guangdong

Huang

Deng

Liu³

et al. 2022

Front. Microbiol.

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Important forensic evidence traced from crime scenes, such as fecal materials, can help in the forensic investigation of criminal cases. Intestines are the largest microbial pool in the human body whose microbial community is considered to be the human “second fingerprint”. The present study explored the potential for community characteristics of gut microbes in forensic medicine. Fecal microbiota profiles of healthy individuals from three representative Han populations (Guangzhou, Shantou and Meizhou) in Guangdong Province, China were evaluated using High-throughput sequencing of V3-V4 hypervariable regions of the 16SrRNA gene. Results of the present study showed that at the genus level, Shantou, Guangzhou, and Meizhou behaved as Enterotype1, Enterotype2, and Enterotype3, which were mainly composed of Bacteroides, Prevotella, and Blautia, respectively. Based on OTU abundance at the genus level, using the random forest prediction model, it was found that there might be potential for distinguishing individuals of Guangzhou, Meizhou, and Shantou according to their fecal microbial community. Moreover, the findings of the microbial community of fecal samples in the present study were significantly different from that of saliva samples reported in our previous study, and thus it is evident that the saliva and feces can be distinguished. In conclusion, this study reported the fecal microbial signature of three Han populations, which may provide basic data for the potential application in forensic practice, containing body fluid identification, and geographical inference.

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A comparison of the prevalence of respiratory pathogens and opportunistic respiratory pathogenic profile of ‘clean’ and ‘unclean’ removable dental prostheses

Lim,

Huang,

Zhang

et al. 2024

Journal of Dentistry

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Proposal of a health gut microbiome index based on a meta-analysis of Korean and global population datasets

Cited by 10 publications

References 114 publications

Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms

Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms

Fecal microbial signatures of healthy Han individuals from three bio-geographical zones in Guangdong

A comparison of the prevalence of respiratory pathogens and opportunistic respiratory pathogenic profile of ‘clean’ and ‘unclean’ removable dental prostheses

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