Proposed Biology of the Spontaneous Remission of Cancer

Abstract

Two common factors were identified among the case reports of the prolonged spontaneous remission and regression of cancer. The prolonged spontaneous remissions of cancer may be preceded by a low blood oxygen delivery to the tumor and a short, steady or rapid malignant growth. The steady or rapid growth of primary tumor not the growth of new metastases. HypotHeses Check for updatesSpontaneous remission of renal cell carcinoma may occur more commonly after nephrectomy in patients with pulmonary metastases. Spontaneous remissions of leukemia may occur more commonly after pneumonia. Spontaneous remission of Merkel cell carcinoma may occur more commonly after biopsy, etc. It is interesting that these specific events are not specific to a type of cancer, they may occur in different types of cancer. Yet, they have a higher propensity in certain types of cancer. A common denominator was sought.The etiology of the spontaneous regression or remission of cancer is unknown. Theories regarding the pathophysiology of the spontaneous regression or remission of cancer vary. It might be attributed to an immune activation, withdrawal of a possible causative agent, hormonal change, change in blood supply, cell apoptosis, tumor necrosis, infection, cytokines, chemokines, herbal remedies, etc. this study suggest that a steady or rapid growth of primary tumor faced with a low blood oxygen may result in a spontaneous regression or remission of cancer. MethodsDifferent disciplines related to cancer were studied such as biology, immunology, endocrinology, neurology, etc. as it relates to cancer. Later focus was made on the reported cases of the spontaneous regression or remission of cancer. Case Reports of the spontaneous remission and regression of cancer since the late 1800's was studied. They were classified as short and temporary or prolonged remissions. Afterwards the case reports of prolonged spontaneous remissions or regressions of cancer were classified by tissue type and events preceding the spontaneous regression or remission of cancer. The events most commonly preceding each

Spontaneous Remission in a Patient with Chronic Myeloid Leukemia: A Case Report

“…Spontaneous resolution of leukemia, although rare and poorly understood, has been observed in various situations such as severe infection, blood product transfusion, immune-mediated processes, and termination of pregnancy [ 13 , 14 ]. It is believed that an immune-mediated process involving the excessive production of inflammatory cytokines stimulates the activity of natural killer cells, T lymphocytes, and macrophages, potentially exerting an antileukemia effect.…”

Proposed Experimental Preparation and Administration of Dendritic Cell Vaccine for Treatment of Cancer (Metastatic Castration-Resistant Prostate Cancer)

“…In previous papers it was suggested that spontaneous remissions or regression of cancer may occur if a low platelet count is present and accompanied by an acute inflammatory response [3][4][5]. It seems the same principal may apply to dendritic cell vaccines.…”

Proposed Biology of the Spontaneous Remission of Merkel Cell Carcinoma after Biopsy

“…The medical literature has many case reports of the spontaneous remission of Merkel cell carcinoma after biopsy [1][2][3][4][5][6][7][8][9][10]. It is noteworthy that prior to the biopsy the Merkel Cell Carcinoma was growing rapidly.…”

“…It is suggested that Spontaneous remission of Merkel cell carcinoma or any other cancer [10] may occur when two conditions are met. A low blood iron and a rapid or steady malignant growth.…”