The concepts of entransy, entransy dissipation and transfer resistance are introduced into liquid desiccant dehumidification analysis to reveal the irreversibility and moisture transfer resistance between moist air and liquid desiccant. By analyzing a typical water (vapor) transfer process coupled with heat transfer, we define the concepts of mass entransy of water and its dissipation, derive the expression of moisture transfer resistance (MTR) that reflects the irreversibility of water transfer during dehumidification processes, and also point out the relationship between MTR and dehumidification performance. With these concepts, both adiabatic and internal cooling liquid desiccant dehumidification systems with various operation conditions are analyzed and optimized. It is found that for the adiabatic dehumidification system, increasing the mass transfer coefficient leads to the reduction of MTR, and consequently, the improvement of dehumidification performance. Meanwhile, for the dehumidification system with internal cooling, in order to reduce the MTR and improve the dehumidification performance, pre-cooling should be centralized ahead of the liquid desiccant inlet when the flow rates ratio of air to desiccant is small, whereas, uniform cooling should be applied when the flow rates ratio of air to desiccant is large. liquid desiccant dehumidification, energy conservation, heat and mass transfer, entransy dissipation, moisture transfer resistance Citation: Chen L, Chen Q, Li Z, et al. Moisture transfer resistance method for liquid desiccant dehumidification analysis and optimization.With social development and living standard progress, air conditioning becomes more and more popular in our daily life. However, it consumes a large amount of energy to create a comfortable habitation. For a traditional vapor compression air conditioner using condensation dehumidification, the evaporation temperature must be lower than the air dew-point temperature in order to dehumidify air, which decreases the refrigeration efficiency. Besides, the air is so cold that it has to be reheated before it is supplied to conditioned area requiring precise temperature control, and reheating will further increase both system complexity and energy consumption. In the interest of releasing the restriction that the evaporation temperature must be lower than the air dew-point temperature, researchers developed the independent temperature and humidity control system [1], where moist air was first dehumidified with desiccant and then cooled. In this way, the evaporation temperature is higher than the air dew-point temperature, leading to the improvement of refrigeration efficiency. Liquid desiccant dehumidification is to dehumidify moist air by using such solutions as lithium bromide (LiBr) and/or lithium chloride (LiCl) which have lower vapor pressure than that of moist air [2][3][4][5]. In this dehumidification process, there are simultaneously heat and mass transfer between moist air and liquid desiccant, where the heat transfer potential is ...