Propranolol and thyroid hormones.

Jones, M. K.; Jones, Gareth R.; Birtwell, J

doi:10.1136/bmj.281.6237.453-d

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“…DL propranolol inhibits T 4 deiodination to T 3 at peripheral sites by a reduction of the T 3 production rate, the clearance of T 3 remaining unaltered (Lumholtz et al 1978). The mechanism by which propranolol exerts this effect is unclear and may not be due solely to its (3-receptor blocking activity for L propranolol, which has no j3 blocking action but is a potent membrane stabiliser, and also reduces serum T 3 levels in hypothyroid subjects receiving T 4 replacement (Jones, Jones and Birtwell 1980).…”

Section: Introductionmentioning

confidence: 99%

The Effect of a β-Receptor Agonist (Salbutamol) on Peripheral Thyroid Metabolism in Euthyroid Subjects

Walker¹,

Jung²,

Jennings³

et al. 1981

Horm Metab Res

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IntroductionIt is now well documented that DL propranolol produces a decrease in plasma concentrations of L-triiodothyronine (T 3 ) and a rise in serum reverse T 3 (rT 3 ) in euthyroid, hyperthyroid and hypothyroid subjects on thyroxine (T 4 ) supplements (Harrower, Fyffe, Horn and Strong 1977; Lumholtz, Siersbaek-Nielsen, Faber, Kirkegaard and Frits 1978;Jung, Shetty and James 1980). DL propranolol inhibits T 4 deiodination to T 3 at peripheral sites by a reduction of the T 3 production rate, the clearance of T 3 remaining unaltered (Lumholtz et al. 1978). The mechanism by which propranolol exerts this effect is unclear and may not be due solely to its (3-receptor blocking activity for L propranolol, which has no j3 blocking action but is a potent membrane stabiliser, and also reduces serum T 3 levels in hypothyroid subjects receiving T 4 replacement (Jones, Jones and Birtwell 1980).

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Section: Introductionmentioning

confidence: 99%