The Effect of a β-Receptor Agonist (Salbutamol) on Peripheral Thyroid Metabolism in Euthyroid Subjects

Walker, Niki L.; Jung, R. T.; Jennings, G.; James, W. P. T.

doi:10.1055/s-2007-1019346

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…However, administration of adrenoceptor agonists also seems to interact with either thyroid hormone secretion or metabolism. In previous studies it was found that terbutaline, administered to normal-weight subjects fed on a normal diet, significantly increased the serum T3 level and the serum T3/T4 ratio [14,321, although this effect has not been confirmed by others [35]. In our study we found that both the.…”

Section: Discussioncontrasting

confidence: 74%

Effects of chronic administration of ephedrine during very-low-calorie diets on energy expenditure, protein metabolism and hormone levels in obese subjects

et al. 1992

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1. We investigated the effects of the chronic administration of a sympathomimetic agent on energy expenditure, protein metabolism and levels of thyroid hormones and catecholamines in 10 obese subjects after a 6-week very-low-calorie-diet programme (1965 kJ, 60 g of protein, 45 g of carbohydrates). L-(-)-Ephedrine hydrochloride (50 mg three times a day by mouth) or placebo were administered during 2-week periods (weeks 2-5 of the VLCD programme) in a randomized, double-blind, cross-over design. Five subjects began with ephedrine and five with placebo. 2. The results were analysed separately in the two groups. No difference was found between them as regards weight loss during the very-low-calorie diet and drug treatments. Conversely, ephedrine therapy induced a significantly lower daily urinary excretion of nitrogen (and, consequently, a better nitrogen balance) with respect to placebo, independently of the drug sequence. Daily urinary levels of 3-methylhistidine during ephedrine and placebo treatments were similar. The fasting resting metabolic rate (oxygen consumption, ml STP/min) fell significantly during the very-low-calorie diet in both groups, but this effect was partially and significantly prevented by administration of ephedrine. Diet therapy significantly reduced 24 h urine levels of vanillylmandelic acid and homovanillic acid, which, however, increased to pretreatment values during ephedrine treatment. No significant effects were shown on 24 h urinary concentrations of adrenaline, noradrenaline and dopamine during the very-low-calorie diet and/or ephedrine treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussioncontrasting

confidence: 74%

Effects of chronic administration of ephedrine during very-low-calorie diets on energy expenditure, protein metabolism and hormone levels in obese subjects

et al. 1992

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“…35,36 On the other hand, beta-adrenergic agonists have not been reported to cause significant changes in thyroid function tests. 37…”

Section: ■ Beta-blockers Beta-agonists and Thyroid Functionmentioning

confidence: 99%

A 66-year-old man with abnormal thyroid function tests

Alhalaseh

Abdulelah

Armouti

et al. 2019

CCJM

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Effects of Chronic β-Receptor Stimulation on Sympathetic Nervous System Activity, Energy Expenditure, and Thyroid Hormones*

Scheidegger

O’Connell

Robbins

et al. 1984

The Journal of Clinical Endocrinology & Metabolism

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The effects of hyper- and hypothyroidism on sympathetic nervous system activity and energy expenditure are well recognized. The impact of altered sympathetic nervous system activity on energy expenditure and thyroid hormone metabolism has not been well studied. We investigated the effects of orally administered terbutaline sulfate, a beta 2-receptor agonist (5 mg, three times per day for 2 weeks), on the activity of the sympathetic nervous system, energy expenditure, and thyroid hormone metabolism in six normal men, aged 21-36 yr. The cardiovascular, metabolic, and thermogenic responses to an infusion of the beta-adrenergic agonist isoproterenol were clearly blunted after 2 weeks of treatment with terbutaline sulfate, indicating down-regulation of beta-receptors and/or development of reduced sensitivity. There were no significant changes in the cardiovascular, metabolic, or thermogenic responses to an infusion of the alpha-adrenergic agonist phenylephrine. Basal metabolic rate was significantly increased by the chronic administration of terbutaline sulfate [5.040 +/- 0.167 (+/- SE) vs. 5.421 +/- 0.234 kJ/min; P less than 0.05]. There was a highly significant change in the serum T3 to T4 ratio (19.4 +/- 1.0 vs. 24.4 +/- 1.0; P less than 0.001). This was a result of increased serum T3 concentrations (136 +/- 9 vs. 160 +/- 14 ng/dl; P less than 0.05) and decreased serum T4 concentrations (7.2 +/- 0.8 vs. 6.7 +/- 0.8 micrograms/dl; P = NS). Chronic beta-receptor stimulation with terbutaline sulfate increases the basal metabolic rate and T3 concentrations. These changes occurred despite down-regulation of beta-receptors and/or decreased sensitivity in response to chronic terbutaline administration.

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The Effect of a β-Receptor Agonist (Salbutamol) on Peripheral Thyroid Metabolism in Euthyroid Subjects

Cited by 3 publications

References 5 publications

Effects of chronic administration of ephedrine during very-low-calorie diets on energy expenditure, protein metabolism and hormone levels in obese subjects

Effects of chronic administration of ephedrine during very-low-calorie diets on energy expenditure, protein metabolism and hormone levels in obese subjects

A 66-year-old man with abnormal thyroid function tests

Effects of Chronic β-Receptor Stimulation on Sympathetic Nervous System Activity, Energy Expenditure, and Thyroid Hormones*

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