Propranolol Inhibits the Spontaneous Closure of the Ductus Arteriosus in Newborn Rats.

Arishima, Kazuyoshi; Takizawa, Takeo; Oda, Takashi; Yamamoto, Masahide; Togashi, H; Somiya, Hiroaki; Eguchi, Yawara

doi:10.1292/jvms.57.943

Cited by 3 publications

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“…However, the PDE3 inhibitors milrinone and amrinone 26,27 and the PDE5 inhibitor, sildenafil 28, which are currently in use in the NICU, have consistent vasodilatory effects on the ductus, and have been proposed to serve an adjunct role in maintaining ductus patency and extending the bridge to corrective surgery for congenital heart disease. Finally, beta-adrenergic catecholamine receptors also stimulate vascular smooth muscle relaxation and have been detected in the ductus, although there is conflicting information on whether they play a vasodilatory role 29,30.…”

Section: Drugs or Compounds With Recognized Vasodilatory Effects On Tmentioning

confidence: 99%

Inadvertent Relaxation of the Ductus Arteriosus by Pharmacologic Agents that are Commonly Used in the Neonatal Period

Reese

Veldman

Shah

et al. 2010

Seminars in Perinatology

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Premature birth and disruption of the normal maturation process leave the immature ductus arteriosus unable to respond to postnatal cues for closure. Recent strategies that advocate conservative management of the patent ductus arteriosus (PDA) in premature infants are dependent on identification of the symptomatic PDA and understanding the risk factors that predispose to PDA. Exposure of premature infants to unintended vasodilatory stimuli may be one of the risk factors for PDA that is under-recognized. In this paper, we summarize the clinical factors that are associated with PDA and review commonly used neonatal drugs for their vasodilatory properties. Data demonstrating relaxation of the ductus arteriosus by gentamicin and other aminoglycoside antibiotics, by cimetidine and other H2 receptor antagonists, and by heparin are provided as examples of neonatal therapies that have unanticipated effects that may promote PDA.

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Section: Drugs or Compounds With Recognized Vasodilatory Effects On Tmentioning

confidence: 99%

Inadvertent Relaxation of the Ductus Arteriosus by Pharmacologic Agents that are Commonly Used in the Neonatal Period

Reese

Veldman

Shah

et al. 2010

Seminars in Perinatology

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“…Furthermore, in the presence of the -adrenoceptor antagonist phenoxybenzamine, norepinephrine was able to relax lamb DA preparations, but the eVects were modest even at the highest doses (Bodach et al 1980). In the newborn rat, propanolol paradoxically delayed DA closure (Arishima et al 1995), but it has been suggested that this is secondary to the eVects of -adrenergic blockade on the perinatal cardiovascular homeostasis and not due to a direct eVect on ductal tone (Smith 1998). On the other hand, in the guinea pig DA, phenoxybenzamine converts the contractile eVect of norepinephrine to a relaxation and isoproterenol causes a marked relaxation (Bodach et al 1980).…”

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confidence: 99%

Developmental changes in the effects of prostaglandin E2 in the chicken ductus arteriosus

et al. 2008

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Prostaglandin E 2 (PGE 2 ) is the major vasodilator prostanoid of the mammalian ductus arteriosus (DA). In the present study we analyzed the response of isolated DA rings from 15-, 19-and 21-day-old chicken embryos to PGE 2 and other vascular smooth muscle relaxing agents acting through the cyclic AMP signaling pathway. PGE 2 exhibited a relaxant response in the 15-day DA, but not in the 19-and 21-day DA. Moreover, high concentrations of PGE 2 (¸3 M in 15-day and ¸1 M in 19-day and 21-day DA) induced contraction of the chicken DA. The presence of the TP receptor antagonist SQ29,548, unmasked a relaxant eVect of PGE 2 in the 19-and 21-day DA and increased the relaxation induced by PGE 2 in the 15-day DA. The presence of the EP receptor antagonist AH6809 abolished PGE 2 -mediated relaxation. The relaxant responses induced by PGE 2 and the -adrenoceptor agonist isoproterenol, but not those elicited by the adenylate cyclase activator forskolin or the phosphodiesterase 3 inhibitor milrinone, decreased with maturation. High oxygen concentrations (95%) decreased the relaxation to PGE 2 . The relaxing potency and eYcacy of isoproterenol and milrinone were higher in the pulmonary than in the aortic side of the DA, whereas no regional diVerences were found in the response to PGE 2 . We conclude that, in contrast to the mammalian situation, PGE 2 is a weak relaxant agent of the chicken DA and, with advancing incubation, it even stimulates TP vasoconstrictive receptors.

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The Pharmacology of the Ductus Arteriosus

Smith

1998

Pharmacological Reviews

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Propranolol Inhibits the Spontaneous Closure of the Ductus Arteriosus in Newborn Rats.

Cited by 3 publications

References 0 publications

Inadvertent Relaxation of the Ductus Arteriosus by Pharmacologic Agents that are Commonly Used in the Neonatal Period

Inadvertent Relaxation of the Ductus Arteriosus by Pharmacologic Agents that are Commonly Used in the Neonatal Period

Developmental changes in the effects of prostaglandin E2 in the chicken ductus arteriosus

The Pharmacology of the Ductus Arteriosus

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