Pros and cons of antioxidant use during radiation therapy

Prasad, Kedar N.; Cole, William C.; Kumar, Bipin; Prasad, Kavita

doi:10.1053/ctrv.2002.0260

Cited by 108 publications

(89 citation statements)

References 54 publications

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“…Dietary intake of anti-oxidant sources (vegetables and fruit) did not change significantly during the study period, and the decrease of vitamin E is in concert with the findings of Guren et al [10], showing a transient decrease in cobolamin before, during and shortly after RT. Whether anti-oxidants should be given while the cancer is still under treatment is controversial [31]. A review of prophylactic and therapeutic strategies in radiation enteropathy emphasizes the problem of differential protection, i.e.…”

Section: Measurements Related To Nutritionmentioning

confidence: 99%

Time patterns of changes in biomarkers, symptoms and histopathology during pelvic radiotherapy

Larsen

Bjørge²,

Klementsen³

et al. 2007

Acta Oncologica

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Section: Measurements Related To Nutritionmentioning

confidence: 99%

Time patterns of changes in biomarkers, symptoms and histopathology during pelvic radiotherapy

Larsen

Bjørge²,

Klementsen³

et al. 2007

Acta Oncologica

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“…1,2 Currently, the use of antioxidant supplements during radiation therapy is a controversial issue, since it is feared that they could interfere with treatment. 3,4 We conducted a double-blind, placebo-controlled, randomized trial among head and neck cancer patients treated by radiation therapy to assess the effects of a supplementation combining alpha tocopherol and beta carotene on outcomes of head and neck cancer patients. Contrary to expectation, the supplementation had adverse effects on the recurrence of the initial cancer, on the incidence of second primary cancers and on mortality.…”

mentioning

confidence: 99%

Interaction between antioxidant vitamin supplementation and cigarette smoking during radiation therapy in relation to long‐term effects on recurrence and mortality: A randomized trial among head and neck cancer patients

Meyer

Bairati

Fortin

et al. 2008

Intl Journal of Cancer

111

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There has been concern that the efficacy of radiation therapy may be reduced when patients smoke or take antioxidant vitamins during treatment. Cancer prevention trials with beta carotene supplements documented adverse effects only among smokers. We conducted a randomized trial with alpha tocopherol (400 IU/day) and beta carotene (30 mg/day) supplements among 540 head and neck cancer (HNC) patients treated by radiation therapy. We examined whether smoking during radiation therapy modified the effects of the supplementation on HNC recurrence and on mortality. During the follow-up, 119 patients had a HNC recurrence and 179 died. Cox models were used to test the interaction between smoking and supplementation and to estimate the hazard ratios (HR) for HNC recurrence and death associated with the supplementation. Cigarette smoking either before or after radiation therapy did not modify the effects of the supplementation. In contrast, the interactions between supplementation and cigarette smoking during radiation therapy were statistically significant for HNC recurrence (p 5 0.03), all-cause mortality (p 5 0.02) and mortality from the initial HNC (p 5 0.04). Among cigarette smokers, the HR were 2.41 (95% CI: 1.25-4.64) for recurrence, 2.26 (95% CI: 1.29-3.97) for all-cause mortality and 3.38 (95% CI: 1.11-10.34) for HNC mortality. All corresponding HR among nonsmokers were close to 1. These results could best be explained by the hypothesis that the combined exposures reduced the efficacy of radiation therapy. Particular attention should be devoted to prevent patients from both smoking and taking antioxidant supplements during radiation therapy. ' 2007 Wiley-Liss, Inc.

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“…Dietary antioxidants can induce cell differentiation as well as inhibit proliferation and apoptosis depending on the dose and type of antioxidant, treatment schedule and tumor cell type without producing similar effects in most normal cells in vitro and in vivo (30,31). However, whether there is a relationship between the antioxidant and anticancer activity is a controversial issue at present.…”

Section: Discussionmentioning

confidence: 99%

Potential antioxidant and antiproliferative activities of a hot-water extract from the root of Tonh khidum

Liu

Zhang²,

Xing³

et al. 2010

Oncology Letters

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Abstract. In this study, for the first time, the possible antioxidant and antiproliferative activities of a hot-water extract (TW100) from the root of Tonh khidum (Actinidia kolomikta Maxim) were examined in vitro. Total phenolic compound, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity and superoxide dismutase (SOD)-like activity assays were utilized to investigate its antioxidant activity. As a result, TW100 showed a strong antioxidant activity. The total phenolic content of TW100 was 143 µg gallic acid equivalents/mg. The SOD-like activity of TW100 was 666,667 U/g extract, and the DPPH radicalscavenging activity was 129 µg/ml at EC 50 which was one third of vitamin E (40 µg/ml). The antiproliferative effects and ability of the extracts to induce apoptosis were studied in vitro using human cervical cancer ME-180 cells. Results showed that TW100 inhibited the proliferation of ME-180 cells in a dose-and time-dependent manner except at a low concentration (10 µg/ml) with an EC 50 at 24, 48 and 72 h of 36.28, 30.55 and 29.78 µg/ml, respectively. TW100 also induced apoptosis as determined by a nuclear fragmentation assay and an analysis of flow cytometry. In conclusion, the hot-water extract from the root of Tonh khidum possesses potential antioxidant and antiproliferative activities.

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Pros and cons of antioxidant use during radiation therapy

Cited by 108 publications

References 54 publications

Time patterns of changes in biomarkers, symptoms and histopathology during pelvic radiotherapy

Time patterns of changes in biomarkers, symptoms and histopathology during pelvic radiotherapy

Interaction between antioxidant vitamin supplementation and cigarette smoking during radiation therapy in relation to long‐term effects on recurrence and mortality: A randomized trial among head and neck cancer patients

Potential antioxidant and antiproliferative activities of a hot-water extract from the root of Tonh khidum

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