PROSAFE: a European endeavor to improve quality of critical care medicine in seven countries

Finazzi, Stefano; Paci, Giulia; Antiga, Luca; Brissy, Obou; Carrara, Greta; Crespi, Daniele; Csató, Gábor; Csomós, Ákos; Duek, Or; Facchinetti, Sara; Fleming, Joanne; Garbero, Elena; Gianni, M.C.; Gradišek, Primož; Kapš, Rafael; Kyprianou, Theodoros; Lazar, Isaac; Mikaszewska-Sokolewicz, Małgorzata; Mondini, Matteo; Nattino, Giovanni; Olivieri, Carlo; Poole, Daniele; Previtali, Claudio; Radrizzani, D.; Rossi, Carlotta; Skurzak, Stefano; Tavola, Mario; Xirouchaki, Nektaria; Bertolini, Guido

doi:10.23736/s0375-9393.20.14112-9

Cited by 21 publications

(10 citation statements)

References 22 publications

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“…Independently of the data source, model performance remains stable over time. This is an important finding because longstanding ICU registries require less effort for data-collection, integration, and processing than setting up a specific research data set from multiple EHR with different data unless such data platform is already in place, which is currently rare but upcoming ( giviti.marionegri.it/portfolio/covid-19/ , last access 11/02/2022) [5] , [36] , [37] . When EHRs will move to using information standards and/or FAIR data, many of the current disadvantages of EHR data may disappear, since collection, integration and processing will be eased.…”

Section: Discussionmentioning

confidence: 99%

Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients: A retrospective cohort study in the Netherlands comparing the value of registry data with high-granular electronic health records

Vagliano

Schut²,

Abu‐Hanna³

et al. 2022

International Journal of Medical Informatics

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Section: Discussionmentioning

confidence: 99%

Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients: A retrospective cohort study in the Netherlands comparing the value of registry data with high-granular electronic health records

Vagliano

Schut²,

Abu‐Hanna³

et al. 2022

International Journal of Medical Informatics

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“…It should be noted that this review does not include a wider approach. A wider approach to antimicrobial stewardship that includes other professionals working in the ICU, infectious disease wards, cardio-surgery units, etc., for whom the possibility of spreading knowledge about the risk of multi-resistant strains and protocols to reduce the risk is of fundamental importance [ 78 ]. Pharmacists can play a role in controlling AMR by actively incorporating TDM and PK/PD theories that utilize specialized pharmacokinetics.…”

Section: Discussionmentioning

confidence: 99%

A Strategy for Hospital Pharmacists to Control Antimicrobial Resistance (AMR) in Japan

2021

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In Japan, there is concern regarding the relation between the inappropriate use of antibiotics and antibiotic resistance (AMR). Increased bacterial resistance is due in part to the inappropriate use of antimicrobial agents. The support of the pharmacist becomes important, and there is growing interest in antimicrobial stewardship to promote the appropriate and safe use of antimicrobials needed for the optimal selection of drugs, doses, durations of therapy, therapeutic drug monitoring (TDM), and implementations of cost containment strategies in Japan. Pharmacists should strive to disseminate the concept of “choosing wisely” in relation to all medicines, implement further interventions, and put them into practice. In this article, we present data for antimicrobial stewardship and Japan’s AMR action plan, focusing on how pharmacists should be involved in enabling physicians to choose antimicrobials wisely.

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“…Patients’ characteristics were collected using an electronic case report form (eCRF), including demographics, trauma characteristics, clinical conditions at emergency rescue team arrival and at admission to the emergency department and ICU, comorbidities, details of computed tomography (CT) scans in the first hours after trauma, and outcomes. The eCRF was built upon the existing PROSAFE framework, implementing several completeness and validy checks to guarantee the uniformity of the collected data [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Hospitals with and without neurosurgery: a comparative study evaluating the outcome of patients with traumatic brain injury

Giugni

Gamberini

Carrara

et al. 2021

Scand J Trauma Resusc Emerg Med

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Background We leveraged the data of the international CREACTIVE consortium to investigate whether the outcome of traumatic brain injury (TBI) patients admitted to intensive care units (ICU) in hospitals without on-site neurosurgical capabilities (no-NSH) would differ had the same patients been admitted to ICUs in hospitals with neurosurgical capabilities (NSH). Methods The CREACTIVE observational study enrolled more than 8000 patients from 83 ICUs. Adult TBI patients admitted to no-NSH ICUs within 48 h of trauma were propensity-score matched 1:3 with patients admitted to NSH ICUs. The primary outcome was the 6-month extended Glasgow Outcome Scale (GOS-E), while secondary outcomes were ICU and hospital mortality. Results A total of 232 patients, less than 5% of the eligible cohort, were admitted to no-NSH ICUs. Each of them was matched to 3 NSH patients, leading to a study sample of 928 TBI patients where the no-NSH and NSH groups were well-balanced with respect to all of the variables included into the propensity score. Patients admitted to no-NSH ICUs experienced significantly higher ICU and in-hospital mortality. Compared to the matched NSH ICU admissions, their 6-month GOS-E scores showed a significantly higher prevalence of upper good recovery for cases with mild TBI and low expected mortality risk at admission, along with a progressively higher incidence of poor outcomes with increased TBI severity and mortality risk. Conclusions In our study, centralization of TBI patients significantly impacted short- and long-term outcomes. For TBI patients admitted to no-NSH centers, our results suggest that the least critically ill can effectively be managed in centers without neurosurgical capabilities. Conversely, the most complex patients would benefit from being treated in high-volume, neuro-oriented ICUs.

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PROSAFE: a European endeavor to improve quality of critical care medicine in seven countries

Cited by 21 publications

References 22 publications

Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients: A retrospective cohort study in the Netherlands comparing the value of registry data with high-granular electronic health records

Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients: A retrospective cohort study in the Netherlands comparing the value of registry data with high-granular electronic health records

A Strategy for Hospital Pharmacists to Control Antimicrobial Resistance (AMR) in Japan

Hospitals with and without neurosurgery: a comparative study evaluating the outcome of patients with traumatic brain injury

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