Prospective Analysis of LDL-C Goal Achievement and Self-Reported Medication Adherence Among Statin Users in Primary Care

Bermingham, Margaret; Hayden, John; Dawkins, Ian; Miwa, Saki; Gibson, Denise; McDonald, Ken; Ledwidge, Mark

doi:10.1016/j.clinthera.2011.07.007

Cited by 41 publications

(34 citation statements)

References 29 publications

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“…The Mann Whitney test identified significant differences on the level of physical activity and the characteristics of medication treatments; the users with complaints presented higher level of total physical activity (p=0.03), besides the higher dose consumption (p=0.05) for longer (p=0.04). In general, the non-adherence to the treatment with statins is a preoccupant reality, once it can be considered the main responsible to fail in attending the therapeutic goals (24) . In the present study it was verified that patients who did not follow the medical prescription were those who presented more altered lipid profile values, as well as the more elevated biochemical levels when compared to adherent patients.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the measure of adherence to statins, the major part of studies measure it indirectly (12) , and the count of pills, the control of medicaments taken away in pharmacies and the application of questionnaires can be used (12,28) . Although the low sensibility and accuracy, the questionnaires are well utilized due to its low cost and applicability in big populations (28) , being a quick and valid way to identify adherence to the treatment in clinical practice (24) . In Brazil, as well as in other countries, the Morisky-Green test have been broadly used to identify adherence to drug treatments (24,28) and therefore, its adoption is recommended for future studies.…”

mentioning

confidence: 99%

“…Although the low sensibility and accuracy, the questionnaires are well utilized due to its low cost and applicability in big populations (28) , being a quick and valid way to identify adherence to the treatment in clinical practice (24) . In Brazil, as well as in other countries, the Morisky-Green test have been broadly used to identify adherence to drug treatments (24,28) and therefore, its adoption is recommended for future studies.…”

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confidence: 99%

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Adherence to statin treatment and associated factors in female users from the Unified Health System (SUS)

Bonfim

Hansen

Turi

et al. 2014

Rev. esc. enferm. USP

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Objective: To identify the adherence rate of a statin treatment and possible related factors in female users from the Unified Health System. Method: Seventy-one women were evaluated (64.2 ± 11.0 years) regarding the socio-economic level, comorbidities, current medications, level of physical activity, self-report of muscular pain, adherence to the medical prescription, body composition and biochemical profile. The data were analyzed as frequencies, Chi-Squared test, and Mann Whitney test (p<0.05). Results: 15.5% of women did not adhere to the medical prescription for the statin treatment, whose had less comorbidities (p=0.01), consumed less quantities of medications (p=0.00), and tended to be younger (p=0.06). Those patients also presented higher values of lipid profile (CT: p=0.01; LDL-c: p=0.02). Musculoskeletal complains were not associated to the adherence rate to the medication. Conclusion: The associated factors to adherence of dyslipidemic women to statin medical prescription were age, quantity of comorbidities and quantity of current medication.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Adherence to statin treatment and associated factors in female users from the Unified Health System (SUS)

Bonfim

Hansen

Turi

et al. 2014

Rev. esc. enferm. USP

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“…Primary care patients' non-adherence to statin medications was evaluated, and the results showed a low rate of non-adherence, 37% (4). Another study conducted at a different primary care setting found approximately 51% patients did not adhere to statin therapy (5).…”

Section: Introductionmentioning

confidence: 99%

Achievement of LDL Cholesterol Goal and Adherence to Statin by Diabetes Patients in Kelantan

Yudin¹,

Yaacob²,

Ismail³

et al. 2017

MJMS

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Background: Statins are a class of potent drugs that can be used to reduce cholesterol, especially low-density lipoprotein cholesterol (LDL-C). However, their effectiveness is limited if adherence to treatment is poor. The objectives of the study are to estimate the proportion of diabetic patient who has achieved LDL-C goal and to determine the association of LDL-C achievement with socio demographic factors and statin therapy adherence Methods: This is a cross-sectional study involving 234 patients with type 2 diabetes mellitus (T2DM) and dyslipidaemia attending an outpatient clinic in a hospital in Kelantan. Interviews and self-administered questionnaires were used to determine their sociodemographic and clinical characteristics. Adherence to therapy was assessed using the Medication Compliance Questionnaire (MCQ). The associations between the achievement of LDL targets and sociodemographic/clinical factors, including adherence, were analysed with simple logistic regression.Results: About 37.6% of patients achieved their LDL-C target. The percentage of patients who adhered to statin use was 98.3%, and 20.5% of these patients reported full adherence. There was no significant association between achievement of LDL-C targets with adherence or any other sociodemographic factors, such as age, gender and educational or economic status (all P-value < 0.05). Conclusion: Despite a high level of adherence, the majority of patients failed to achieve LDL-C targets. More concerted efforts are needed to improve this.

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“…40 Foody et al (2008) measured statin persistence rates for new users aged 18 years or older in a large national database; median simvastatin persistence rates were 157 days in primary prevention (no previous cardiovascular events, n = 45,558) and 181 days in secondary prevention (n = 4,443). 41 One would expect that "sticker shock" for brand drugs would be more likely to occur in the early months of therapy and that, as time progresses, more common reasons for nonadherence-for example, forgetfulness, lack of a routine or reminder system for taking medication, concerns about side effects, regimen complexity, beliefs about medications, insufficient information about treatment, and emotional issues- [42][43][44][45][46][47] would become more important, thereby potentially further diminishing the already-small effects of the Post-MI FREEE intervention.…”

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confidence: 99%

VBID, the PPACA, and FREEE Medications: Did Politics Trump the Evidence About Cost Sharing?

Fairman¹,

Curtiss²

2012

JMCP

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Prospective Analysis of LDL-C Goal Achievement and Self-Reported Medication Adherence Among Statin Users in Primary Care

Cited by 41 publications

References 29 publications

Adherence to statin treatment and associated factors in female users from the Unified Health System (SUS)

Adherence to statin treatment and associated factors in female users from the Unified Health System (SUS)

Achievement of LDL Cholesterol Goal and Adherence to Statin by Diabetes Patients in Kelantan

VBID, the PPACA, and FREEE Medications: Did Politics Trump the Evidence About Cost Sharing?

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