Prospective analysis of perioperative morbidity in one hundred consecutive colectomies for ulcerative colitis

Hurst, Roger D.; Finco, C; Rubin, Michele; Michelassi, Fabrizio

doi:10.1016/s0039-6060(05)80045-5

Cited by 37 publications

(9 citation statements)

References 14 publications

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“…Proctocolectomy with IPAA is the standard of care for most patients with UC who are either refractory to medical therapy or have dysplasia. Factors that may be associated with poor outcome after IPAA include age older than 50 years and extraintestinal manifestations of IBD (11), urgent colectomy versus elective surgery (3), and an underlying diagnosis of Crohn's disease (CD) (12). Outcome improves with the experience of the surgeon (2) but is not related to the anastomotic technique used (13).…”

Section: Discussionmentioning

confidence: 99%

Azathioprine or 6-Mercaptopurine Before Colectomy for Ulcerative Colitis Is Not Associated With Increased Postoperative Complications

Mahadevan

Loftus²,

Tremaine³

et al. 2002

Inflammatory Bowel Diseases

112

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Section: Discussionmentioning

confidence: 99%

Azathioprine or 6-Mercaptopurine Before Colectomy for Ulcerative Colitis Is Not Associated With Increased Postoperative Complications

Mahadevan

Loftus²,

Tremaine³

et al. 2002

Inflammatory Bowel Diseases

112

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“…Among patients with Crohn's disease undergoing surgery, between 6 and 45 per cent have postoperative complications13, 14 and mortality rates range from 0·5 to 5·5 per cent15, 16. In patients with ulcerative colitis undergoing ileal pouch–anal anastomosis (IPAA), postoperative complications affect 19–58 per cent, the rate decreasing with the experience of the surgeon17–19. The commoner early postoperative complications include abdominal wound infection, anastomotic leakage, pelvic sepsis and small bowel obstruction.…”

Section: Introductionmentioning

confidence: 99%

Systematic review of postoperative complications in patients with inflammatory bowel disease treated with immunomodulators

Subramanian

Pollok

Kang

et al. 2006

British Journal of Surgery

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“…Remission occurs in over 60% of patients but where steroids fail, treatment with cyclosporin A should be considered. This may salvage over 50% of patients, 1 but there is a high early relapse rate.…”

Section: Introductionmentioning

confidence: 99%

Ulcerative colitis – surgical indications and treatment

Nicholls

2002

Aliment Pharmacol Ther

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SUMMARYThe indication for surgery is a balance between the severity of the disease despite full medical treatment and the potential disadvantages of surgery. The decision requires cooperation between gastroenterologist and surgeon.Colectomy with ileostomy and preservation of the rectum in the emergency setting is the accepted procedure and can rapidly restore the patient to normal health allowing withdrawal of anti-inflammatory medication. After recovery all surgical possibilities are then open for the future. The elective indications for surgery include failure of medical treatment, retardation of growth in a child or adolescent and neoplastic transformation. The choice of operation includes conventional proctocolectomy, restorative proctocolectomy (RPC) and colectomy with ileo-rectal anastomosis. Each has relative advantages and disadvantages. RPC is the commonest procedure. It offers a satisfactory outcome in 70-90% of patients with a cumulative failure rate of 10-15% over a 10 year period.Causes of failure include sepsis (50%), dysfunction (30%) and pouchitis (10%). In selected cases salvage surgery to avoid failure can be successful with rates of around 70% for outlet obstruction and fistulation and 50% for pelvic sepsis.

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Prospective analysis of perioperative morbidity in one hundred consecutive colectomies for ulcerative colitis

Cited by 37 publications

References 14 publications

Azathioprine or 6-Mercaptopurine Before Colectomy for Ulcerative Colitis Is Not Associated With Increased Postoperative Complications

Azathioprine or 6-Mercaptopurine Before Colectomy for Ulcerative Colitis Is Not Associated With Increased Postoperative Complications

Systematic review of postoperative complications in patients with inflammatory bowel disease treated with immunomodulators

Ulcerative colitis – surgical indications and treatment

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