Prospective associations between socioeconomically disadvantaged groups and metabolic syndrome risk in European children. Results from the IDEFICS study

Iguacel, Isabel; Michels, Nathalie; Ahrens, Wolfgang; Bammann, Karin; Eiben, Gabriele; Fernández-Alvira, Juan Miguel; Mårild, Staffan; Molnár, Denés; Reisch, Lucia A.; Russo, Paola; Tornaritis, Michael; Veidebaum, Toomas; Wolters, Maike; Moreno, Luís A.; Börnhorst, Claudia

doi:10.1016/j.ijcard.2018.07.053

Cited by 28 publications

(44 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Further, we did not have access to weight gain data in infancy and early childhood, which has been shown to be associated with lower insulin sensitivity in children 54 . Finally, there was a greater proportion of participants from more deprived socioeconomic areas among those born very preterm, and children from socioeconomically disadvantaged families are at higher metabolic risk 55 …”

Section: Discussionmentioning

confidence: 96%

Lower insulin sensitivity remains a feature of children born very preterm

et al. 2020

View full text Add to dashboard Cite

Background The first report of children born very preterm (<32 weeks of gestation) having insulin resistance was made 16 years ago. However, neonatal care has improved since. Thus, we aimed to assess whether children born very preterm still have lower insulin sensitivity than term controls. Methods Participants were prepubertal children aged 5 to 11 years born very preterm (<32 weeks of gestation; n = 51; 61% boys) or at term (37‐41 weeks; n = 50; 62% boys). Frequently sampled intravenous glucose tolerance tests were performed, and insulin sensitivity was calculated using Bergman's minimal model. Additional clinical assessments included anthropometry, body composition using whole‐body dual‐energy X‐ray absorptiometry scans, clinic blood pressure, and 24‐hour ambulatory blood pressure monitoring. Results Children born very preterm were 0.69 standard deviation score (SDS) lighter (P < .001), 0.53 SDS shorter (P = .003), and had body mass index 0.57 SDS lower (P = .003) than children born at term. Notably, children born very preterm had insulin sensitivity that was 25% lower than term controls (9.4 vs 12.6 × 10−4 minutes−1·[mU/L]; P = .001). Other parameters of glucose metabolism, including fasting insulin levels, were similar in the two groups. The awake systolic blood pressure (from 24‐hour monitoring) tended to be 3.1 mm Hg higher on average in children born very preterm (P = .054), while the clinic systolic blood pressure was 5.4 mm Hg higher (P = .002). Conclusions Lower insulin sensitivity remains a feature of children born very preterm, despite improvements in neonatal intensive care. As reported in our original study, our findings suggest the defect in insulin action in prepubertal children born very pretermis primarily peripheral and not hepatic.

show abstract

Section: Discussionmentioning

confidence: 96%

Lower insulin sensitivity remains a feature of children born very preterm

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Socioeconomic disadvantages have been defined as social or economic conditions or events that may negatively affect children ( 32 , 33 ). These stressors can be social conditions (such as being a migrant) or economic situations (such as belonging to a low-income family) and might occur at different levels (individual, household, community, or society level).…”

Section: Classic Ses and Social Disadvantages And Their Consequences mentioning

confidence: 99%

“…Socioeconomic disadvantages include not only these classic SES indicators but also social vulnerabilities that go beyond this term. A number of social vulnerabilities during childhood and adolescence have been examined in recent papers (migrant status, lack of a social network, parental unemployment, teenage pregnancy, not living with two biological parents, or parental substance use) ( 33 , 45 , 46 ). Although the possible effect of these social vulnerabilities in children might be moderated by classic SES indicators, these social vulnerabilities have an independent effect since they are stressors per se .…”

Section: Classic Ses and Social Disadvantages And Their Consequences mentioning

confidence: 99%

Consideration of Social Disadvantages for Understanding and Preventing Obesity in Children

Ayala-Marín

Iguacel

Miguel-Etayo

et al. 2020

Front. Public Health

Self Cite

View full text Add to dashboard Cite

Addressing social disadvantages that lead to obesity should be a public health priority. Obesity prevalence among children and adolescents has reached a plateau in countries with high income but it continues rising in low-income and middle-income countries. In high-income countries, an elevated prevalence of obesity is found among racial and ethnic minority groups and individuals from disadvantaged socioeconomic backgrounds. In addition to classic socioeconomic status (SES) factors, like income, parental education, and occupation, recent publications have linked parental social disadvantages, such as minimal social network, non-traditional family structure, migrant status and unemployment, with obesogenic behaviors and obesity among children. Socio-ecological models of obesity in children can explain the influence of classic SES factors, social disadvantages, culture, and genes on behaviors that could lead to obesity, contributing to the elevated prevalence of obesity. Obesity is a multifactorial disease in which multilevel interventions seem to be the most effective approach to prevent obesity in children, but previous meta-analyses have found that multilevel interventions had poor or inconsistent results. Despite these results, some multilevel interventions addressing specific disadvantaged social groups have shown beneficial effects on children's weight and energy balance-related behaviors, while other interventions have benefited children from both disadvantaged and non-disadvantaged backgrounds. Considering obesity as a worldwide problem, the World Health Organization, the European Commission, and the National Institutes of Health recommend the implementation of obesity prevention programs, but the implementation of such programs without taking into consideration social disadvantages may be an unsuccessful approach. Therefore, the present publication consists of a review of the pertinent literature related to social disadvantage and its consequences for behaviors that could lead to childhood obesity. In addition, we will discuss the relationship between social disadvantages and the socio-ecological model of obesity in children. Finally, we will summarize the relevant aspects of multilevel intervention programs aiming to prevent obesity in children and provide recommendations for future research and intervention approaches to improve weight status in children with social disadvantages.

show abstract

“…This confirmed that the best model fit was achieved when the predictor was dichotomized at the lowest quartile. Based on these results and prior literature utilizing the same dichotomization, [29][30][31][32][33] we classified women with 0 or 1 person to count on in times of need as having low prenatal social support and those with ≥2 people to count on in times of need as having high prenatal social support.…”

Section: Methodsmentioning

confidence: 99%

The Protective Effect of Prenatal Social Support on Infant Adiposity in the First 18 Months of Life

Katzow

Messito

Mendelsohn

et al. 2019

The Journal of Pediatrics

View full text Add to dashboard Cite

Objective: To determine whether prenatal social support was associated with infant adiposity in the first 18 months of life in a low-income, Hispanic sample, known to be at high risk of early child obesity. Study design: We performed a longitudinal analysis of 262 low-income, Hispanic mother-infant pairs in the control group of the "Starting Early" child obesity prevention trial. Prenatal social support was measured using an item from the Maternal Social Support Index. We used multilevel modeling to predict weight-for-length z-score (WFLz) trajectories from birth to age 18 months and logistic regression to predict macrosomia and overweight status at ages 6, 12, and 18 months. Results: High prenatal social support was independently associated with lower infant adiposity trajectories from birth to age 18 months (B=−0.40 (−0.63, −0.16)), lower odds of macrosomia (aOR 0.35 (0.15, 0.80)), and lower odds of overweight at ages 12 (0.28 (0.10, 0.74)) and 18 months (0.35 (0.14, 0.89)). Prenatal social support was not significantly associated with overweight status at age 6 months. Conclusions: Prenatal social support may protect against excessive infant adiposity and overweight in low-income, Hispanic families. Further research is needed to elucidate mechanisms underlying these associations and to inform preventive strategies beginning in pregnancy.

show abstract

Prospective associations between socioeconomically disadvantaged groups and metabolic syndrome risk in European children. Results from the IDEFICS study

Abstract: Children from socioeconomically disadvantaged families are at high metabolic risk independently of diet, physical activity, sedentary behaviours and well-being. Interventions focusing on these socioeconomically disadvantaged groups should be developed to tackle health disparities.

Cited by 28 publications

References 38 publications

Lower insulin sensitivity remains a feature of children born very preterm

Lower insulin sensitivity remains a feature of children born very preterm

Consideration of Social Disadvantages for Understanding and Preventing Obesity in Children

The Protective Effect of Prenatal Social Support on Infant Adiposity in the First 18 Months of Life

Contact Info

Product

Resources

About