Prospective Associations Between Traumatic Brain Injury and Postdeployment Tinnitus in Active-Duty Marines

Yurgil, Kate A.; Clifford, Royce E; Risbrough, Victoria B.; Geyer, Mark A.; Huang, Mingxiong; Barkauskas, Donald A.; Vasterling, Jennifer J.; Baker, Dewleen G.

doi:10.1097/htr.0000000000000117

Cited by 17 publications

(6 citation statements)

References 63 publications

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“…Atypical connectivity in both the Auditory Vigilance/Auditory-2 ICNs among service members may indeed reflect auditory deficits. Noise and head trauma increase the likelihood during or after deployment of developing tinnitus (Yurgil et al., 2016), the most common service-connected disability as of 2016, followed by hearing loss (Department of Veterans Affairs, 2016). This study did not measure tinnitus symptoms or auditory function in participants.…”

Section: Discussionmentioning

confidence: 99%

A resting-state network comparison of combat-related PTSD with combat-exposed and civilian controls

Vanasse

Franklin

Salinas

et al. 2019

Social Cognitive and Affective Neuroscience

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Resting-state functional connectivity (rsFC) is an emerging means of understanding the neurobiology of combat-related post-traumatic stress disorder (PTSD). However, most rsFC studies to date have limited focus to cognitively related intrinsic connectivity networks (ICNs), have not applied data-driven methodologies or have disregarded the effect of combat exposure. In this study, we predicted that group independent component analysis (GICA) would reveal group-wise differences in rsFC across 50 active duty service members with PTSD, 28 combat-exposed controls (CEC), and 25 civilian controls without trauma exposure (CC). Intranetwork connectivity differences were identified across 11 ICNs, yet combat-exposed groups were indistinguishable in PTSD vs CEC contrasts. Both PTSD and CEC demonstrated anatomically diffuse differences in the Auditory Vigilance and Sensorimotor networks compared to CC. However, intranetwork connectivity in a subset of three regions was associated with PTSD symptom severity among executive (left insula; ventral anterior cingulate) and right Fronto-Parietal (perigenual cingulate) networks. Furthermore, we found that increased temporal synchronization among visuospatial and sensorimotor networks was associated with worse avoidance symptoms in PTSD. Longitudinal neuroimaging studies in combat-exposed cohorts can further parse PTSD-related, combat stress-related or adaptive rsFC changes ensuing from combat.

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Section: Discussionmentioning

confidence: 99%

A resting-state network comparison of combat-related PTSD with combat-exposed and civilian controls

Vanasse

Franklin

Salinas

et al. 2019

Social Cognitive and Affective Neuroscience

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“…However, because our study directly evaluates overlap among PCS and other conditions, sleep disturbance was included as an indicator of PCS. We also included an item assessing tinnitus, given evidence that this somatic symptom also may follow TBI (e.g., Yurgil et al, 2016). The internal consistency of the expanded PCS scale used here was good (Cronbach’s alpha = .89).…”

Section: Methodsmentioning

confidence: 99%

Postconcussive, posttraumatic stress and depressive symptoms in recently deployed U.S. Army soldiers with traumatic brain injury.

Agtarap¹,

Campbell‐Sills²,

Michael³

et al. 2019

Psychological Assessment

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Prior studies raise questions about whether persistent postconcussive symptoms (PCS) are differentiable from mental health sequelae of traumatic brain injury (TBI). To investigate whether PCS represented a distinct symptom domain, we evaluated the structure of post-concussive and psychological symptoms using data from The Army STARRS Pre/Post Deployment Study, a panel survey of three U.S. Army Brigade Combat Teams that deployed to Afghanistan. Data from 1229 participants who sustained probable TBI during deployment completed ratings of past-30-day post-concussive, posttraumatic stress, and depressive symptoms three months after their return. Exploratory factor analysis (EFA; n ϭ 300) and confirmatory factor analysis (CFA; n ϭ 929) of symptom ratings were performed in independent subsamples. EFA suggested a model with 3 correlated factors resembling PCS, posttraumatic stress, and depression. CFA confirmed adequate fit of the 3-factor model (CFI ϭ .964, RMSEA ϭ .073 [.070, .075]), contingent upon allowing theoretically defensible cross-loadings. Bifactor CFA indicated that variance in all symptoms was explained by a general factor ( ϭ .36 -.93), but also provided evidence of domain

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“…MRS methodology for TBI assessment has been previously reported (Yurgil et al., ; Yurgil et al., ). At pre‐and postdeployment, history of head injury was assessed through structured interviews with high interrater reliability (Alosco et al., ).…”

Section: Methodsmentioning

confidence: 99%

Fear learning alterations after traumatic brain injury and their role in development of posttraumatic stress symptoms

et al. 2017

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Background: It is unknown how traumatic brain injury (TBI) increases risk for posttraumatic stress disorder (PTSD). One potential mechanism is via alteration of fear-learning processes that could affect responses to trauma memories and cues. We utilized a prospective, longitudinal design to determine if TBI is associated with altered fear learning and extinction, and if fear processing mediates effects of TBI on PTSD symptom change. Methods:Eight hundred fifty two active-duty Marines and Navy Corpsmen were assessed before and after deployment. Assessments included TBI history, PTSD symptoms, combat trauma and deployment stress, and a fear-potentiated startle task of fear acquisition and extinction. Startle response and self-reported expectancy and anxiety served as measures of fear conditioning, and PTSD symptoms were measured with the Clinician-Administered PTSD Scale.Results: Individuals endorsing "multiple hit" exposure (both deployment TBI and a prior TBI) showed the strongest fear acquisition and highest fear expression compared to groups without multiple hits. Extinction did not differ across groups. Endorsing a deployment TBI was associated with higher anxiety to the fear cue compared to those without deployment TBI. The association of deployment TBI with increased postdeployment PTSD symptoms was mediated by postdeployment fear expression when recent prior-TBI exposure was included as a moderator. TBI associations with increased response to threat cues and PTSD symptoms remained when controlling for deployment trauma and postdeployment PTSD diagnosis.Conclusions: Deployment TBI, and multiple-hit TBI in particular, are associated with increases in conditioned fear learning and expression that may contribute to risk for developing PTSD symptoms.

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Prospective Associations Between Traumatic Brain Injury and Postdeployment Tinnitus in Active-Duty Marines

Cited by 17 publications

References 63 publications

A resting-state network comparison of combat-related PTSD with combat-exposed and civilian controls

A resting-state network comparison of combat-related PTSD with combat-exposed and civilian controls

Postconcussive, posttraumatic stress and depressive symptoms in recently deployed U.S. Army soldiers with traumatic brain injury.

Fear learning alterations after traumatic brain injury and their role in development of posttraumatic stress symptoms

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