Prospective clinical study of rehabilitation interventions with multisensory interactive training in patients with cerebral infarction: study protocol for a randomised controlled trial

Lo, Wai Leung Ambrose; Mao, Yu-Heng; Li, Le; Lin, Ai Hua; Zhao, Jiang; Chen, Ling; Lin, Qiang; Li, Hai; Huang, Dong Feng

doi:10.1186/s13063-017-1874-y

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…It is a lower limb motion capture system consisting of seven inertial sensors which provides participants with real-time feedback on motion. It is widely used in the rehabilitation evaluation o f patients after surgery in hospitals (Lo et al 2017). The estimated results of this system were used as the gold standard to verify the reliability of our proposed method.…”

Section: Methodsmentioning

confidence: 99%

A novel gait parameter estimation method for healthy adults and postoperative patients with an ear-worn sensor

Diao¹,

Ma²,

Xu³

et al. 2020

Physiol. Meas.

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Objective: Gait analysis helps to assess recovery during rehabilitation. Previous gait analysis studies are primarily applicable to healthy subjects or to postoperative patients. The purpose of this paper is to construct a new gait parameter estimation platform based on an ear-worn activity recognition (e-AR) sensor, which can be used for both normal and pathological gait signals. Approach: Thirty healthy adults and eight postoperative patients participated in the experiment. A method based on singular spectrum analysis (SSA) and iterative mean filtering (IMF) is proposed to detect gait events and estimate three key gait parameters, i.e. stride time, swing time, and stance time. Main results: Experimental results show that the estimated gait parameters provided by the proposed method are very close to the gait parameters provided by the gait assessment system. For normal gait signals, the average absolute errors of stride, swing, and stance time are 27.8 ms, 35.8 ms, and 37.5 ms, respectively. For pathological gait signals, the average absolute error of stride time is 32.1 ms. Significance: The proposed parameter estimation method can be applied to both general analysis for healthy subjects and rehabilitation evaluation for postoperative patients. The convenience and comfort of the ear-worn sensor increase its potential for practical applications.

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Section: Methodsmentioning

confidence: 99%

A novel gait parameter estimation method for healthy adults and postoperative patients with an ear-worn sensor

Diao¹,

Ma²,

Xu³

et al. 2020

Physiol. Meas.

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“…23 Even more, it has more beneficial effects in poststroke rehabilitation, such as an increased motivation and engagement, 24 cost, and usability. [25][26][27] In addition, VR training is able to facilitate an increased therapy time without necessarily having to rely on a therapist. 28 For these reasons, the number of complex and realistic VR-based interventions is increasing in neurorehabilitation programs in order to enhance the variability and adaptability of the intervention, as well as patients' motivation, after stroke.…”

mentioning

confidence: 99%

Efficacy of Virtual Reality Combined With Real Instrument Training for Patients With Stroke: A Randomized Controlled Trial

Kim

Han

et al. 2019

Archives of Physical Medicine and Rehabilitation

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To investigate the efficacy of real instrument training in virtual reality (VR) environment for improving upper-extremity and cognitive function after stroke. Design: Single-blind, randomized trial. Setting: Medical center. Participants: Enrolled subjects (NZ31) were first-episode stroke, assessed for a period of 6 months after stroke onset; age between 20 and 85 years; patients with unilateral paralysis and a Fugl-Meyer assessment upper-extremity scale score >18. Interventions: Both groups were trained 30 minutes per day, 3 days a week, for 6 weeks, with the experimental group performing the VR combined real instrument training and the control group performing conventional occupational therapy. Main Outcome Measures: Manual Muscle Test, modified Ashworth scale, Fugl-Meyer upper motor scale, hand grip, Box and Block, 9-Hole Peg Test (9-HPT), Korean Mini-Mental State Examination, and Korean-Montreal Cognitive Assessment. Results: The experimental group showed greater therapeutic effects in a time-dependent manner than the control group, especially on the motor power of wrist extension, spasticity of elbow flexion and wrist extension, and Box and Block Tests. Patients in the experimental group, but not the control group, also showed significant improvements on the lateral, palmar, and tip pinch power, Box and Block, and 9-HPTs from before to immediately after training. Significantly greater improvements in the tip pinch power immediately after training and spasticity of elbow flexion 4 weeks after training completion were noted in the experimental group. Conclusions: VR combined real instrument training was effective at promoting recovery of patients' upper-extremity and cognitive function, and thus may be an innovative translational neurorehabilitation strategy after stroke.

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“…Acute cerebral infarction has high mortality rate, morbidity, and disability rate. Acute cerebral infarction seriously threatens the life, health, and quality of life of patients, and also can cause serious economic burden to the family and society [1,2]. Ischemia-reperfusion injury is the injury of tissues and organs caused by ischemia, hypoxia, and oxygen recovery after a period of ischemia and hypoxia.…”

Section: Discussionmentioning

confidence: 99%

“…Acute cerebral infarction is a common ischemic cerebrovascular disease and is one of the important causes of adult disability [1,2]. Ischemia-reperfusion injury is caused by a blood reperfusion injury in ischemic brain tissue, and usually occurs in the treatment stage of ischemic disease [3][4][5], which can aggravate the brain tissue injury.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of MiR-122 Decreases Cerebral Ischemia-reperfusion Injury by Upregulating DJ-1-Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN)/Phosphonosinol-3 Kinase (PI3K)/AKT

Xue

Wang

Su³

2020

Med Sci Monit

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Departmental sources Background: Ischemia-reperfusion injury is caused by a blood reperfusion injury in ischemic brain tissue, and usually occurs in the treatment stage of ischemic disease, which can aggravate brain tissue injury. MiR-122 is closely related to ischemia-reperfusion injury in the myocardium, kidney, and liver; however, the role in cerebral ischemiareperfusion injury has not been established. Material/Methods: In this study, cerebral ischemia-reperfusion injury was established in a rat model, and the control group was a sham-operated group. After ischemia-reperfusion injury for 6, 12, and 24 hours, brain tissue specimens were collected and the expression of miR-122 and DJ-1 were determined using quantitative real-time polymerase chain reaction. Flow cytometry was used to determine the reactive oxygen species (ROS) content. The modified Neurological Severity Score (mNSS) scale was used to evaluate the sensory and motor function defects of the rats. The malondialdehyde (MDA), superoxide dismutase (SOD), and enzyme activity were determined. The rats in the cerebral ischemia-reperfusion injury model were divided into 2 groups (antagomir-NC group and antagomir miR-122 group). Brain neuron RN-c cells were divided into the following 4 groups: antagomir-NC, antagomir miR-122, pIRES2-blank, and pIRES2-DJ-1. Seventy-two hours after transfection, ischemia-reperfusion treatment was carried out and conventional cultured RN-c cells were used as the control group. Flow cytometry was used to detect apoptosis and western blot was used to detect the expression of DJ-1, PTEN, AKT, and p-AKT. Results: The expression of miR-122 increased significantly in the process of ischemia-reperfusion damage after cerebral infarction, while the expression of DJ-1 decreased significantly. Downregulation of miR-122 significantly increased the expression of DJ-1, enhanced the activity of the PTEN/PI3K/AKT pathway, reduced cell apoptosis, and alleviated cerebral ischemia-reperfusion injury. Conclusions: Inhibition of miR-122 can decrease cerebral ischemia-reperfusion injury by upregulating DJ-1-PTEN/PI3K/AKT pathway.

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Prospective clinical study of rehabilitation interventions with multisensory interactive training in patients with cerebral infarction: study protocol for a randomised controlled trial

Cited by 8 publications

References 48 publications

A novel gait parameter estimation method for healthy adults and postoperative patients with an ear-worn sensor

A novel gait parameter estimation method for healthy adults and postoperative patients with an ear-worn sensor

Efficacy of Virtual Reality Combined With Real Instrument Training for Patients With Stroke: A Randomized Controlled Trial

Inhibition of MiR-122 Decreases Cerebral Ischemia-reperfusion Injury by Upregulating DJ-1-Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN)/Phosphonosinol-3 Kinase (PI3K)/AKT

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