Prospective comparison of course of disability in antipsychotic‐treated and untreated schizophrenia patients

Thirthalli, Jagadisha; Venkatesh, Basappa K.; Kishorekumar, Kengeri V.; Arunachala, Udupi; Venkatasubramanian, Ganesan; Subbakrishna, D.K.; Gangadhar, Bangalore N.

doi:10.1111/j.1600-0447.2008.01299.x

Cited by 67 publications

(50 citation statements)

References 21 publications

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“…Medication and treatment adherence is a big barrier in treating psychiatric illness like schizophrenia,[10] as most patients do have insight about their illness. Further the nature of schizophrenia itself, where patients experience negative symptoms,[11] may make it difficult for them to attend the yoga treatment consistently for the required period of time.…”

Section: Discussionmentioning

confidence: 99%

Barriers to yoga therapy as an add-on treatment for schizophrenia in India

et al. 2012

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Aim:To describe the possible barriers to yoga therapy for patients with schizophrenia in India.Materials and Methods:In a randomized control trial at NIMHANS, patients with schizophrenia (on stable doses of antipsychotics, 18–60 years of age, with a Clinical Global Impression-Severity score of 3 or more) were randomized into one of three limbs: Yoga therapy, physical exercise and waitlist. Of 857 patients screened, 392 (45.7%) patients were found eligible for the study. Among them, 223 (56.8%) declined to take part in the trial. The primary reasons for declining were analyzed.Results:The primary reasons for declining were (a) distance from the center (n=83; 37.2%); (b) no one to accompany them for training (n=25; 11.2%); (c) busy work schedule (n=21, 9.4%); (d) unwilling to come for one month (n=11; 4.9%), (e) not willing for yoga therapy (n=9, 4.0%); (f) personal reasons (n=3, 1.3%); (g) religious reasons (n=1, 0.4%). In 70 patients (31.6%), no reasons were ascribed. No patient refused citing research nature of the intervention as a reason.Conclusion:More than half of the patients eligible for yoga did not consent to the study. Logistic factors, such as the need for daily training under supervision in a specialized center for long periods, are the most important barriers that prevent patients with schizophrenia from receiving yoga therapy. Alternative models/schedules that are patient-friendly must be explored to reach the benefit of yoga to patients with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Barriers to yoga therapy as an add-on treatment for schizophrenia in India

et al. 2012

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“…In a longitudinal study of schizophrenia patients in rural south India, Thirthalli et al ., compared the outcome in patients who did versus did not receive treatment, and found that the disability was clearly better in those who received treatment. [33] In a controlled study, Kulhara et al .,[34] showed that structured psychoeducational intervention was significantly better than routine outpatient care on several outcome indices. Early interventions are therefore feasible and acceptable in low-resource settings.…”

Section: Introductionmentioning

confidence: 99%

Early intervention in psychotic disorders: Challenges and relevance in the Indian context

Keshavan

Shrivastava

Gangadhar

2010

Indian J Psychiatry

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Over the last two decades, there has been an increasing interest in the concept of early intervention (EI) in psychotic disorders, notably schizophrenia. Several lines of research underlie this emerging paradigm shift: (a) an increasingly well-established association between the duration of prolonged untreated illness and poor outcome; (b) evidence of progressive neurobiological changes in the early course of schizophrenia both in the pre-psychotic and psychotic phases, as evidenced by brain imaging studies in schizophrenia; and (c) emerging data, albeit preliminary, suggesting the efficacy and effectiveness of EI programs in improving the outcome in these patients. Mental health service systems across the globe, including Asian countries, have been incorporating specialized early intervention programs. However, literature on EI in the Indian setting is relatively sparse. In this article, we will review the rationale and approaches to EI and the application of these approaches to the Indian context, in light of the available literature. We also examine the constraints in the implementation of EI. Controlled data are needed to evaluate EI and the roadblocks to them, in order to implement EI in the resource-strapped mental health service settings in India.

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“…The proportion of patients classified as "disabled" declined significantly in the treated group, but remained the same in the untreated group (Thirthalli et al 2009). …”

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confidence: 90%