Prospective evaluation of sestamibi scan, ultrasonography, and rapid PTH to predict the success of limited exploration for sporadic primary hyperparathyroidism

Diagnostic Accuracy of 4D-CT for Parathyroid Adenomas and Hyperplasia

“…By comparison, sonography has a cited sensitivity for lateralization ranging from 57% to 86%. 5,11 4D-CT appears to hold potential for detection of multi- gland disease. Although this technique demonstrated suboptimal sensitivity of 44% in patients with multigland disease, it was 100% specific for ruling out multigland disease, as no cases that were thought to have multigland disease by 4D-CT had single-gland adenomas at pathology.…”

Current Status and Treatment of Primary Hyperparathyroidism

“…However, a prospective study evaluating the use of ultrasound, sestamibi scan, and IO-PTH assay in 350 patients with sporadic primary HPT found that the combination of the 3 studies had a 9% failure rate if a unilateral approach was undertaken, though these data may be related to the lower number of solitary adenomas (69%) and higher number of double adenomas or hyperplasia (14% and 17% respectively) found than that generally reported in the literature. 35 As one might expect, a criticism of the unilateral approach is that it may underestimate the incidence of multiple-gland disease. A study of 45 patients who underwent bilateral neck exploration found an incidence of double adenoma or hyperplasia of 13% compared with 0% in 35 patients who underwent focal neck exploration.…”

Tumor Pardo Multifocal Como Manifestación Del Hiperparatiroidismo Primario Por Adenoma Paratiroideo Asociado a Carcinoma Papilar De Tiroides

“…A pesar de que la coexistencia de estas dos entidades es rara, el diagnóstico de patología tiroidea debe ser considerado en aquellos pacientes con hiperparatiroidismo primario, para su resolución simultánea 40 .…”