Prospective Interventional Study to Evaluate the Effect of Siddha Intervention Kabasura Kudineer as a Prophylactic Measure Among High Risk Population Exposed to Covid-19

Abstract

Background: Covid19 a massive threat to public health worldwide addressed the need of Clinical interventions to decrease the incidence and severity of illness. Aim of the study is to assessObjectives: the effectiveness of Siddha intervention- Kabasura Kudineer in prophylaxis of COVID-19 with the assessment of laboratory parameters before and after intervention. The secondary objective is observance of any Adverse Reaction due to consumption of Kabasura Kudineer. The subjects selected for the study are initially subjected to clinical examination, biochemicalMethods: Investigation, assessment of Immune status and quality of life. Kabasura Kudineer was given to the subjects and advised to take it as per the prescribed dosage for 14 days. Subjects was observed for occurrence of mild to moderate symptoms of COVID-19. The follow-up period is another 14 days and after that, the clinical assessment was carried out. The clinicalResults: assessment of 400 subjects enrolled showed improvement in quality of life through WHO-QOL-BREF assessment. The ISQ score is increased in all cases after the intake of Kabasura Kudineer and follow-up. There was no incidence of Covid 19 in subjects taken the Siddha intervention. Haemoglobin level of 76% Subjects taken KSK showed strong positive correlation (r = 0.9) and great signicance (t18 = -5.29, p < 0.001) with 95% CI. The RBC count value of 56% subjects treated with KSK exhibited strong positive correlation (r = 0.87) and signicance (t13 = 4.41, p < 0.001). No incidence of COVID-19 in highConclusion: risk population of this interventional study concludes that the immunomodulatory activity of the drug may support for the prevention of Covid 19 infection.