Prospective memory in patients with first-onset schizophrenia and their non-psychotic siblings

Prospective memory predicts medication management ability and correlates with non-adherence to medications in individuals with clinically stable schizophrenia

“…Wang et al's (2009) meta-analysis concluded that patients with chronic schizophrenia (duration of illness (DOI) ranging from 4.7 to 26.1 years) have significant time-, event-, and activity-based PM impairments. PM impairments have also been reported recently in patients with early schizophrenia (Lui et al, 2011;Zhou et al, 2012).…”

Forming implementation intentions improves prospective memory in early psychosis

“…The present results, in showing poorer performance in eventbased PM in an early psychosis sample, are consistent with those of Lui et al (2011). They employed an early onset schizophrenia group and argued that the poorer performance on event-based PM in these patients is likely to be due to a difficulty in allocating adequate cognitive resources between the ongoing and PM tasks, a difficulty commonly associated with damage to the prefrontal area of the brain in patients with schizophrenia.…”

“…As in their study, the use in the present study of an early onset group makes it less likely that the effect on PM observed is attributable to the effects of longterm medication or a history of negative experiences stemming from hospitalisation and unemployment. Although our early psychosis sample had received antipsychotic medications, the current finding is less likely to be confounded by long-term medication effect on PM and supports the position adopted by Lui et al (2011) and Henry et al (2007) that PM is a primary deficit.…”

“…Aggregate PM performance across different types of PM was found to correlate negatively with duration of illness, medication dosage, general level of psychopathology, and age, and positively with education, and IQ. In other work, PM deficits were found to occur early in the course of the disorder (Lui et al, 2011;Zhou et al, 2012), and to be independent of general cognitive difficulties, executive function deficit, or problems with retrospective memory (Henry et al, 2007). Deficits in PM in older age individuals were shown by Chasteen et al (2001) to be remediable to some degree by having participants form implementation intentions.…”

A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings

“…In the light of these previous findings, we hypothesised that PM is an endophenotype of schizophrenia. The methodology of this study has been discussed elsewhere [18]. Our findings suggest that schizophrenia has significant group effect on PM performance even after other memory, attention, and executive functions were controlled for.…”