Prospective memory performance in individuals with Parkinson’s disease who have mild cognitive impairment.

Abstract

PD patients with MCI (both single and multiple domains) showed lower accuracy on all PM conditions than both HC and PDNC patients. This was predicted by their scores on shifting indices. Conversely, PM accuracy of PDNC patients was comparable to HCs. Regression analyses revealed that PD patients' PM performance significantly predicted scores on daily living scales Conclusions: Results suggest that PM efficiency is not tout-court reduced in PD patients, but it specifically depends on the presence of MCI. Moreover, decreased executive functioning, but not episodic memory failure, accounts for a significant proportion of variance in PM performance. Finally, PM accuracy indices were found to be associated with measures of global daily living functioning and management of medication.

Time-based prospective memory functioning in mild cognitive impairment associated with Parkinson’s disease: relationship with autonomous management of daily living commitments

“…In particular, we evaluated the relative contribution of PM scores to the score variability on the Pill questionnaire (Dubois et al, 2007b ), taking into account the weight of other relevant cognitive (i.e., global cognitive functioning, episodic memory and executive abilities), affective (i.e., depression and apathy) and motor (severity of extrapiramidal symptoms) variables. According to previous evidence of an association between PM failure and reduced daily living functioning also in PD patients (Pirogovsky et al, 2012 ; Costa et al, 2015a ), we expected that PM performance would predict the ability of PD patients with MCI to autonomously manage their own medication.…”

“…In particular, in that study PD patients with and without mild cognitive impairment (MCI) and healthy controls were administered an event-based task in focal (the PM target was processed in the ongoing task) and non-focal (the PM target was not processed during the ongoing task) conditions. Results documented that PD patients with MCI performed worse than both healthy controls and PD patients without MCI, who in turn performed comparably (Costa et al, 2015a ). These findings have clinical relevance because they suggest that PM disorders may be a specific sign of MCI associated with PD.…”

“…Findings of a recent study also raised the question of whether PM weakness is tout-court related to PD in PD patients or whether it is the expression of cognitive impairment (Costa et al, 2015a ). In particular, in that study PD patients with and without mild cognitive impairment (MCI) and healthy controls were administered an event-based task in focal (the PM target was processed in the ongoing task) and non-focal (the PM target was not processed during the ongoing task) conditions.…”

“…In a recent investigation this relationship was also described in PD patients with MCI. In particular, in a sample of PD patients with single-domain and multiple-domain MCI event-based PM scores were found to significantly predict scores on the Pill questionnaire, a tool aimed at ascertaining whether PD patients are able to autonomously manage pharmacological therapy (Costa et al, 2015a ). This was the first study directly aimed at exploring this issue, which is undoubtedly worthy of further investigation.…”

Prospective Memory Impairments in Alzheimer’s Disease and Behavioral Variant Frontotemporal Dementia: Clinical and Neural Correlates

“…Compromised PM performance represents one of the most pervasive forms of memory disturbance in dementia and is viewed by caregivers as more disruptive than retrospective memory failures [25]. PM dysfunction is consistently demonstrated irrespective of dementia syndrome, with difficulties reported in Parkinson's Disease patients with cognitive impairment [26] and in amnestic and dysexecutive subtypes of Mild Cognitive Impairment [27]. In addition, while impairments of retrospective episodic memory are considered to be a characteristic feature of AD [1], a number of studies suggest that PM failures occur at least as frequently in this population and are as severe [25].…”