Time-based prospective memory functioning in mild cognitive impairment associated with Parkinson’s disease: relationship with autonomous management of daily living commitments

Abstract

Objective: Prospective memory (PM), that is, the ability to keep in memory and carry out intentions in the future, is reported to be impaired in individuals with Parkinson’s disease (PD). PM failure may be also associated with reduced daily living functioning in these patients. Little is known, however, about the relationship between mild cognitive impairment (MCI) and time-based PM functioning in PD patients and the possible impact of PM deficits on patients’ autonomy in daily living. Here we aimed to investigate whether MCI associated with PD affects time-based PM. We also wished to determine whether PM impairment accounts for reduced autonomous management of medication in these patients.Method: The study included 48 PD patients with MCI, 33 PD patients without cognitive disorders (PDN) and 20 healthy controls. The time-based PM procedure required that subjects perform an action after a fixed time. The PM procedure was incorporated in the standard neuropsychological assessment. One score was computed for the ability to retrieve the intention (prospective component) and one for remembering the action to be executed (retrospective component). The Pill Questionnaire was administered to assess the ability to manage medication.Results: PD patients with MCI performed less accurately in the PM procedure than HC and tended to perform poorer than PDN. Moreover, in PD patients with MCI, accuracy on the prospective component of the PM task and performance on the Modified Card Sorting Test significantly predicted the ability to manage medication.Conclusions: Results document that reduced efficiency of time-based PM processes in PD is specifically related to the presence of MCI. The same data indicate that PM weakness may be associated with impaired daily living functioning and decreased autonomy.

An Impairment of Prospective Memory in Mild Alzheimer’s Disease: A Ride in a Virtual Town

“…Another main finding of this study is that, besides the fact that the recall of both the prospective and retrospective components was found impaired in patients, they encountered greater difficulty recalling the retrospective component than the prospective one. This finding is not in line with two previous studies showing fairly similar impairment of the recall of both components (Jones et al, 2006; Costa et al, 2015) but is not counterintuitive as the recall of retrospective component is thought to rely primarily on retrospective episodic memory (Hainselin et al, 2011), which is dramatically impaired in AD. Interestingly, when they correctly recalled the prospective component of EB intentions, and gave an answer for the retrospective component, patients with AD tended to provide a prototypical but incorrect action (e.g., “at the newsstand, I buy a newspaper” instead of “I buy a TV program”).…”

Inhibitory dysfunction may cause prospective memory impairment in temporal lobe epilepsy (TLE) patients: an event-related potential study

“…Prospective positivity component: This component is an EPR indicator of switching from an ongoing to PM activity ( Bisiacchi et al, 2009 ; West, 2011 ). Task switching is essential for PM performance in daily living ( Costa et al, 2015 ; Faraut et al, 2021 ). PM deficits has been reported to adversely affect the recall of information about COVID pandemic ( Aizpurua et al, 2021 ).…”

Encoding strategy training and self-reported everyday prospective memory in people with Parkinson disease: a randomized-controlled trial

“…People with PD consistently demonstrate prospective memory deficits in laboratory studies (Ramanan & Kumar, 2013) and report more everyday prospective memory failures compared to healthy older adults (Foster, McDaniel, Repovs, & Hershey, 2009; Pirogovsky, Woods, Vincent Filoteo, & Gilbert, 2012). Further, prospective memory problems in people with PD relate to activity limitations and reduced health-related quality of life (Costa, Peppe, et al, 2015; Costa, Zabberoni, et al, 2015; Pirogovsky et al, 2012). Interventions that improve prospective memory in people with PD could positively impact daily function and clinical care for this population.…”