2008
DOI: 10.1016/j.spinee.2006.12.006
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Prospective nonrandomized comparison of an allograft with bone morphogenic protein versus an iliac-crest autograft in anterior cervical discectomy and fusion

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Cited by 196 publications
(143 citation statements)
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“…Major complications included one vertebral artery injury (successfully embolized without sequelae) and one cerebrospinal fluid fistula (adequately treated with duragen/fibrin sealant without shunting); both occurred in patients with OPLL. Three minor complications occurred: [1] an obese patient required elective plate revision 3 weeks postoperatively due to low positioning of inferior screws, [2] a second patient developed a transient deltoid paresis which spontaneously resolved within 3 months, and [3] one patient was minimally symptomatic from a mild pulmonary embolism which was successfully managed with an inferior vena cava [IVC] filter without anticoagulation.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Major complications included one vertebral artery injury (successfully embolized without sequelae) and one cerebrospinal fluid fistula (adequately treated with duragen/fibrin sealant without shunting); both occurred in patients with OPLL. Three minor complications occurred: [1] an obese patient required elective plate revision 3 weeks postoperatively due to low positioning of inferior screws, [2] a second patient developed a transient deltoid paresis which spontaneously resolved within 3 months, and [3] one patient was minimally symptomatic from a mild pulmonary embolism which was successfully managed with an inferior vena cava [IVC] filter without anticoagulation.…”
Section: Resultsmentioning
confidence: 99%
“…[4] Two other studies documented that utilizing BMP/INFUSE as a bone graft supplement for 1-ACDF spacers was not cost-effective, as it markedly exacerbated postoperative dysphagia, prolonged the LOS, and increased operative costs. [311]…”
Section: Discussionmentioning
confidence: 99%
“…Tumialan et al noted a decrease in dysphagia with a dosage reduction from 2.1 mg/level down to 0.7 mg/level, and from multilevel compared to single-level procedures [99]. In a prospective non-randomized study Buttermann compared BMP-2 with allograft against IC autograft in ACDF [23]. Using 0.9 mg BMP/level he found that although both groups demonstrated similar clinical improvements, 50% of the BMP group suffered dysphagia caused by neck swelling compared to 14% autograft.…”
Section: Bone Morphogenetic Protein (Bmp)mentioning
confidence: 99%
“…Unfortunately, the use of autogenous bone is associated with a significant degree of donor-site morbidity [1][2][3][4]. To avoid this adverse outcome, various bone graft substitutes, such as allograft [5,6], xenograft [4], DBM (demineralized bone matrix) [2], and cages [1,[6][7][8][9][10][11][12][13][14] have been used.…”
Section: Introductionmentioning
confidence: 99%