Prospective Phase II Study of the Efficacy of Transcutaneous Electrical Nerve Stimulation in Post-radiation Patients

Vijayan, Anitha; Asha, M. L.; Babu, S.; Chakraborty, Santam

doi:10.1016/j.clon.2014.09.004

Cited by 18 publications

(20 citation statements)

References 19 publications

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“…Vijayan et al (2014) verified the acute effects of TENS (at frequency of 50 Hz) applied on the parotid glands region of patients submitted to RT and found an increase in the production of saliva of 0.06 mL/minute (130%). Electrical stimulation via acupuncture needles also increased the SSF over 4, 6, 9 and 15 months of follow‐up (increments from 65% to 83%) .…”

Section: Discussionmentioning

confidence: 99%

Effects of transcutaneous electrical nerve stimulation on the salivary flow of patients with hyposalivation induced by radiotherapy in the head and neck region—A randomised clinical trial

Paim

Berbert

Zanella

et al. 2019

J of Oral Rehabilitation

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Hyposalivation is a frequent complication after treatment with radiotherapy. To evaluate the efficacy of transcutaneous electrical nerve stimulation (TENS) on the hyposalivation assessed through stimulated salivary flow (SSF). In this clinical trial, 68 patients (with hyposalivation) were randomly assigned to control (n = 31) or TENS (n = 37) group. Participants in control group received habitual care, while those in TENS group received 8 sessions (20 minutes each) delivered twice a week for four weeks. The electrodes were attached over the skin covering the salivary glands. The electric pulse was adjusted at a frequency of 50 Hz, pulse width of 250 μs and as intense as tolerated. SSF was evaluated through sialometry. Self‐perception of salivary flow (SPSF) and quality of life (QL) was evaluated prior to, during and at 1, 3 and 6 months after treatment. Although no changes were observed in the control group for SSF at any timepoints, TENS group showed a progressive increase in SSF from the third session until the end of the treatment. Significant improvements were also found in SPSF, especially when the SSF reached values ≥0.7 mL/minute. The most expressive results were evident at 6 months after treatment so that SSF, SPSF and QL remained significantly higher (F = 9.5, P = 0.0001; H = 143.77, P < 0.0001; χ2 = 9.162, P = 0.02, respectively). TENS was effective at improving hyposalivation. The benefits on SSF, SPSF and QL give base to a promising therapeutic strategy for patients with hyposalivation after radiotherapy treating head and neck cancer.

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Section: Discussionmentioning

confidence: 99%

Effects of transcutaneous electrical nerve stimulation on the salivary flow of patients with hyposalivation induced by radiotherapy in the head and neck region—A randomised clinical trial

Paim

Berbert

Zanella

et al. 2019

J of Oral Rehabilitation

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“…Vijayan, et al (2014) (13) applied TENS (500HZ) in bilateral parotid glands and found an average increase of 0.06 mL/min, which represents an increase by 130%. Their findings are similar to the ones in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…There is scarce scientific evidence available in the literature. Existing research (12,13) raises the possibility of using this technique as a way to reestablish salivary flow. However, in the published studies, application occurred in patients who had undergone RT through the IMRT or the 3D methods (12,13) , which entail a higher chance of success in the technique, because lesser damage is expected in salivary glands.…”

Section: Introductionmentioning

confidence: 99%

“…Existing research (12,13) raises the possibility of using this technique as a way to reestablish salivary flow. However, in the published studies, application occurred in patients who had undergone RT through the IMRT or the 3D methods (12,13) , which entail a higher chance of success in the technique, because lesser damage is expected in salivary glands. Moreover, the studies differ as to the method of saliva collection, devices and size of electrodes, neither do they report important information, e.g., intensity tolerated or even the method of sialometryused.…”

Section: Introductionmentioning

confidence: 99%

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Efeito agudo da Transcutaneous Electric Nerve Stimulation (TENS) sobre a hipossalivação induzida pela radioterapia na região de cabeça e pescoço: um estudo preliminar

Paim

Macagnan

Martins

et al. 2018

CoDAS

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“…Transcutaneous electrical nerve stimulation (TENS) increases salivary flow rate in healthy adults and in patients with symptomatic xerostomia after head‐neck radiotherapy possibly through the stimulation of the auriculotemporal nerve that supplies secretomotor drive to the parotid gland. In the study of Yang et al, a total of 80 patients on chronic hemodialysis patients were randomly assigned to a treatment group (receiving a 250 µs; 50 Hz TENS) and a control group (receiving an effectively placebo dose of 50 µs; 2 Hz TENS) at acupoints ST 6 and TE17, three times a week for 3 weeks. In the treatment group, the salivary flow rates (mL/min) were significantly higher at week 3 (0.30 ± 0.14), week 4 (0.48 ± 0.10) and week 5 (0.36 ± 0.10) than at week 1 (0.09 ± 0.08); they did not change significantly in the control group.…”

Section: Therapymentioning

confidence: 99%

Xerostomia in patients on chronic hemodialysis: An update

Bossola

2019

Seminars in Dialysis

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Xerostomia, or dryness of oral cavity, is relatively common in patients on chronic hemodialysis and significantly impairs their quality of life. Xerostomia is often the consequence of reduced salivary flow resulting from atrophy and fibrosis of the salivary glands, an event that is of uncertain origin. Many medications commonly used in dialysis patients may also cause or exacerbate xerostomia. Its consequences may be serious and disturbing and include difficulties in chewing, swallowing, tasting, and speaking; increased risk of oral disease, including lesions of the mucosa, gingiva and tongue; bacterial and fungal infections, such as candidiasis, dental caries, and periodontal disease; interdialytic weight gain resulting from increased fluid intake; and a reduction in the quality of life. Therapeutically, stimulation of the salivary glands to increase the production of saliva mechanically by chewing-gum, mouthwash, acupressure, or transcutaneous electrical stimulation has had modest success. However, the long-term effectiveness of such treatments still needs to be investigated and defined. Xerostomia remains a frustrating and disturbing symptom for patients on hemodialysis. Further efforts should be made to find the causes and the mechanisms of the reduced salivary flow observed in patients on chronic hemodialysis.

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Prospective Phase II Study of the Efficacy of Transcutaneous Electrical Nerve Stimulation in Post-radiation Patients

Cited by 18 publications

References 19 publications

Effects of transcutaneous electrical nerve stimulation on the salivary flow of patients with hyposalivation induced by radiotherapy in the head and neck region—A randomised clinical trial

Effects of transcutaneous electrical nerve stimulation on the salivary flow of patients with hyposalivation induced by radiotherapy in the head and neck region—A randomised clinical trial

Efeito agudo da Transcutaneous Electric Nerve Stimulation (TENS) sobre a hipossalivação induzida pela radioterapia na região de cabeça e pescoço: um estudo preliminar

Xerostomia in patients on chronic hemodialysis: An update

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