Prospective Phase II Trial of Concomitant Boost Radiotherapy For Stage II Nasopharyngeal Carcinoma: An Evaluation of Response and Toxicity

Abstract

This C-Boost radiotherapy regimen administers a substantially higher biologically effective dose compared with conventional radiation schedules. Preliminary locoregional control and survival rates are promising with no significant acute and/or late toxicities.

A systematic review of dysgeusia induced by cancer therapies

“…In one study, dysgeusia complaints seemed proportional to the RT dose to the parotid gland [2]. In another study which followed patients over time, the frequency of dysgeusia as a complaint decreased over time [22]. In all studies, the severity of dysgeusia was rated as mild [2,8,17,22,34].…”

“…In all studies, the severity of dysgeusia was rated as mild [2,8,17,22,34]. In four before and after (i.e., quasi-experimental, noncontrolled, non-randomized) studies involving RT alone, the rate of dysgeusia ranged from 16-100% [7,8,19,22] and was usually reported as mild to moderate in severity.…”

Prognostic Impact of Primary Tumor Volume in Patients With Nasopharyngeal Carcinoma Treated by Definitive Radiation Therapy

“…It is well accepted that larger tumor volumes represent increased tumor clonogens and hypoxia which may be the direct cause of reduced radiation efficacy, 8–11 and the prognostic value of tumor volume has also been suggested in several retrospective studies for nasopharyngeal cancer 12–16 . It has been recognized that local control of nasopharyngeal cancer is associated with radiation dose used, and unconventional radiotherapy modality with higher biological equivalent dose, such as brachytherapy and accelerated hyperfractionated concomitant boost radiation, may further improve treatment outcome 17,18 . However, the predictive value of primary tumor volume [gross tumor volume of the primary site (GTV‐P) in our study] on patients' prognosis after radiotherapy, particularly with higher biological equivalent doses, has never been studied in a prospective fashion.…”

Characteristics of symptom distress in Chinese nasopharyngeal carcinoma patients and its relation to mood disturbance: A cross‐sectional study

“…Post‐RT symptom clusters differ depending on disease stage (Wu et al, ). In terms of acute radiation toxicity, the most frequent complication is mucositis in the second and third weeks of treatment (Lu et al, ). Additional acute RT‐related symptoms include appearance changes, severe oral‐pharyngeal pain, dry mouth, difficulty swallowing, difficulty opening one's mouth, hearing loss, changes in taste sensation and dermatitis (grade 1 or 2) (Giro et al, ; Huang, Wilkie, Chapman, & Ting, ; Huang, Wilkie, Schubert, & Ting, ; Koutcher, Wolden, & Lee, ; Lai et al, ).…”