1999
DOI: 10.1097/00019048-199911000-00009
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Prospective, Randomized, Comparative Trial of Ciprofloxacin Otic Drops, with or Without Hydrocortisone Otic Suspention in the Treatment of Acute Diffuse Otitis Externa

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Cited by 26 publications
(33 citation statements)
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“…The efficacy of neomycin-polymixin B-hydrocortisone has been shown in clinical studies to have cure rates ranging from 87% to 97%. 7,8 Efficacy in published reports has also remained consistent over the past 2 decades. 7 However, there are some limitations.…”
Section: Treatmentmentioning
confidence: 59%
“…The efficacy of neomycin-polymixin B-hydrocortisone has been shown in clinical studies to have cure rates ranging from 87% to 97%. 7,8 Efficacy in published reports has also remained consistent over the past 2 decades. 7 However, there are some limitations.…”
Section: Treatmentmentioning
confidence: 59%
“…An earlier randomized, controlled trial, in which a ciprofloxacin 0.2%/hydrocortisone 1.0% (CIP/HC) otic suspension was compared with N/P/H in 842 patients aged ≥ 2 years with AOE, found no statistically significant differences between these two preparations in terms of clinical and microbiologic response rates 23 . This raises the question as to whether the combination of ciprofloxacin with the more potent corticosteroid dexamethasone (0.1%) is an important factor giving rise to the therapeutic superiority of CIP/DEX over N/P/H in the present study, or whether the disparity between the results of the two studies is due to methodological differences or other confounding factors.…”
Section: Discussionmentioning
confidence: 99%
“…In AOE patients, a number of clinical studies have demonstrated the efficacy and safety of topical ciprofloxacin when administered as a solution of 0.2% or 0.3% alone or in combination with hydrocortisone 1.0% [20][21][22][23] . Recently, ciprofloxacin has been formulated as an otic suspension of 0.3% with dexamethasone 0.1% (which is a more potent corticosteroid than hydrocortisone) with the objective of providing more rapid relief of inflammation and pain.…”
Section: Introductionmentioning
confidence: 99%
“…In a study by Pistorius et al [11] of 239 patients diagnosed with acute external otitis and treated with 0.2% ciprofloxacin for 7 days, the bacteria eradication rate was 92%. In the same study, 236 patients with AOE were treated with 0.2% ciprofloxacin+0.1% hydrocortisone for 7 days, and the bacteria eradication rate was 95%.…”
Section: Discussionmentioning
confidence: 98%