Prospective Randomized Evaluation of Idiopathic Hyperoxaluria Treatments

Gupta, Mantu; Gallante, Blair; Bamberger, Jacob; Khusid, Johnathan A.; Parkhomenko, Egor; Chandhoke, Ryan; Capodice, Jillian L.; Atallah, William

doi:10.1089/end.2021.0122

Cited by 7 publications

(7 citation statements)

References 17 publications

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“…Similar results were found by Gupta et al. ( 2021 ) who mentioned that a low‐oxalate diet is helpful in serum oxalate reduction. Bargagli et al., also mentioned that removing high‐oxalate content food items and encouraging healthy low‐oxalate content food choices for patients helps in maintaining a normal serum oxalate level (Bargagli et al., 2020 ).…”

Section: Resultssupporting

confidence: 89%

“…The baseline data were comprised of anthropometric measurements (weight), 24 h dietary recall, a Renal Function test, an Electrolyte profile test (Wyatt & Drüeke, 2020), Blood oxalate test (Gupta et al, 2021) and a 24 h urine test was done as mentioned by Atallah et al (2018) The method used was authorized by the Research Ethical Committee of The University of Lahore (IRB-UOL-FASH/70111274/2021). All the participants signed an informed consent form.…”

Section: Methods Of Data Collectionmentioning

confidence: 99%

“…The participants who met the study inclusion criteria were enrolled and divided into two groups: the conventional diet group (T 1 ) and the low‐oxalate diet group (T 2 ) for 8 weeks as mentioned in Table 2 . The baseline data were comprised of anthropometric measurements (weight), 24 h dietary recall, a Renal Function test, an Electrolyte profile test (Wyatt & Drüeke, 2020 ), Blood oxalate test (Gupta et al., 2021 ) and a 24 h urine test was done as mentioned by Atallah et al. ( 2018 ) The method used was authorized by the Research Ethical Committee of The University of Lahore (IRB‐UOL‐FASH/70111274/2021).…”

Section: Methodsmentioning

confidence: 99%

“…This diet also promotes urine citrate excretion, an important inhibitor of calcium stones because of the increased number of fruits, greens, and little quantity of meat items. The consumption of calcium ought not to be minimized because it creates associations with oxalate or limits its utilization (Gupta et al., 2021 ). Fluids or water intake should be 2–3 liter/day because it helps in the removal of calcium oxalate stones from the kidney.…”

Section: Introductionmentioning

confidence: 99%

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Impact of low‐oxalate diet on hyperoxaluria among patients suffering from nephrolithiasis

Aziz,

Noreen,

Tufail

et al. 2024

Food Science & Nutrition

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Low‐oxalate diets are useful for treating hyperoxaluria in nephrolithiasis patients. This study was unique in examining how a low‐oxalate diet in addition to a standard diet affected hyperoxaluria and renal function tests in nephrolithiasis patients. The effects of a low‐oxalate diet were analyzed by different biochemical tests, that is, anthropometric measurements, blood oxalate test, renal function test, electrolyte profile test, and 24 h urine analysis. For this purpose, 112 patients were divided into 2 groups: Group T1 (Conventional diet) and Group T2 (Low‐Oxalate diet) for 8 weeks. Each group was tested at the initiation and end of the study. Using SPSS, the obtained data from each parameter were statistically analyzed. The results showed that a low‐oxalate diet had a positive effect on patients suffering from nephrolithiasis. Furthermore, after treatment, anthropometric measurement weight (kg) among the control group (T1) was 100.45 ± 5.65 and the treatment group (T2) was 79.71 ± 9.48 kg. The effect of low‐oxalate diet on renal function test: creatinine (g/d) among T1 was 2.08 ± 0.86 and T2 was 1.17 ± 0.13, uric acid(mg/d) among T1 was 437.04 ± 24.20 and T2 was 364.61 ± 35.99, urinary oxalate (mg/d) among T1 was 76.84 ± 10.33 and T2 was 39.24 ± 1.51, respectively. Sodium (mEq/d) among T1 was 156.72 ± 6.37 and T2 was 159.84 ± 6.31, potassium (mEq/d) among T1 was 69.91 ± 15.37 and T2 was 89.21 ± 6.31, phosphorus (g/d) among T1 was 0.96 ± 0.07 and T2 was 0.34 ± 0.27, respectively. This study demonstrated that nephrolithiasis patients with hyperoxaluria benefit from low‐oxalate diets. Hyperoxaluria patients should eat a low‐oxalate diet to use oxalate without affecting metabolism and eliminate it from the kidney without stones.

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Section: Resultssupporting

confidence: 89%

Section: Methods Of Data Collectionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of low‐oxalate diet on hyperoxaluria among patients suffering from nephrolithiasis

Aziz,

Noreen,

Tufail

et al. 2024

Food Science & Nutrition

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show abstract

“…Although dietary oxalate is directly correlated with urinary oxalate excretion [ 86 , 87 ], intestinal oxalate absorption depends not only on dietary oxalate intake but also on dietary calcium intake. Diets with higher calcium lead to reduced intestinal oxalate absorption, while restricted calcium diets are associated with enhanced oxalate absorption and increased urinary oxalate excretion [ 65 , 88 ].…”

Section: Oxalatementioning

confidence: 99%

Diet and Stone Disease in 2022

Dai

Pearle

2022

JCM

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Diet plays a central role in the development and prevention of nephrolithiasis. Although pharmacologic treatment may be required for some patients who are resistant to dietary measures alone, dietary modification may be sufficient to modulate stone risk for many patients. While there is no single specialized diet for stone prevention, several dietary principles and recommendations for stone prevention are supported by practice guidelines, including adequate fluid intake, modest calcium intake, low dietary sodium, and limited animal protein. In this review, we summarized the evidence supporting these dietary recommendations and reviewed the current literature regarding specific dietary components and comprehensive diets for stone prevention.

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