Prospective randomized study on perioperative enteral immunonutrition in laparoscopic colorectal surgery

Abstract

Perioperative immunonutrition proved to be safe and useful in increasing the perioperative immunologic cell response. It may contribute toward improving the preparation and relaxation of the intestinal loops despite the shorter intestinal preparation.

Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: A review

“…Nutritional formulas for improving immunity (immunonutrition) of patients with gastrointestinal cancer contain, apart from n-3 PUFAs, L-glutamine, L-arginine, and RNA. Preoperative, perioperative and postoperative administration of PUFA-enriched nutrition (oral, enteral or parenteral) could have an impact on the postoperative inflammatory response after major abdominal surgery in cancer patients or laparoscopic colorectal surgery 158 . Generally, in clinical trials, trends toward decreased infection, hospital stay and treatment costs have been found after preoperative immunonutrition.…”

Efeito da suplementação dietética de arginina na cicatrização das anastomoses colônicas em ratos

“…O conceito implica em indicar-se adequadamente cada imunonutriente, tais como glutamina, selênio, óleo de peixe (ácidos graxos -3) e arginina, a cada situação clínica, entre elas desnutrição, queimaduras, trauma, pacientes em estado crítico ou em síndrome de estresse respiratório agudo. Basearam sua argumentação no fato que os diversos estudos apresentados até o momento incorrem em erros metodológicos diversos, como seleção inadequada da amostra para estudo, uso de produtos para o estudo que associam diversos imunonutrientes 2,4,13,17,28,35,38,43 . Nesta linha de raciocínio, alguns autores estão buscando limitar o foco da amostra.…”

Effects of a nutritional intervention in a fast-track program for a colorectal cancer surgery: systematic review

“…The mean age of the included patients was between 16 and 94 years (5,8), except one of them (16) that had a small group of children of 10 years, whom were not considered in this revision and only adults were included in the review. Men were more predominant within 18 (66.6%) of the studies (10)(11)(12)(13)(14)(17)(18)(19)(20)22,23,(25)(26)(27)(28)(29)(30)(31) and there was no mention about sex proportion in 2 (7.4%) works (6,8). Most of the studies proposed 2 groups, the intervention group (fast-track, G-FT) and the control group (traditional, G-T), only in 2 works 4 groups were designed (22,28) (Table I).…”

“…Most of the studies proposed 2 groups, the intervention group (fast-track, G-FT) and the control group (traditional, G-T), only in 2 works 4 groups were designed (22,28) (Table I). The number of treated patients was available in all works, some of them had the same number in each study group (6,7,13,15,17,20). The postoperative follow-up varied by time and used method ranging from a minimum of 3 postoperative days (POD) and a maximum of 29 POD (8,11,12,(15)(16)(17)19,22,27), only on author didn't mention the total follow-up period (9).…”

“…To reinforce the articles quality assessment the Critical Appraisal Skills Programme Spain (CASPe) was used among its 11 items applying the first three of them for screening and the questionnaire for the quantification of the critical analysis of scientific studies: clinical trials (CACEC-EC) which with its initial screening part reject the papers that don't reach the score of 6 points and has the following quality assessment values: low (0-6), good (7)(8)(9)(10)(11)(12)(13)(14) and excellent (15)(16)(17)(18)(19)(20).…”