Prospective Study of Clinical Phenotypes in Neuropsychiatric Systemic Lupus Erythematosus; Multidisciplinary Approach to Diagnosis and Therapy

Zirkzee, Elisabeth J. M.; Steup-Beekman, Gerda M; Mast, Roos C. van der; Bollen, E.; Wee, Nic J.A. van der; Baptist, Esther; Slee, Thomas M; Huisman, Menno V.; Middelkoop, Huub A. M.; Luyendijk, J.; Buchem, Mark A. van; Huizinga, Tom W J

doi:10.3899/jrheum.120545

Cited by 65 publications

(69 citation statements)

References 43 publications

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“…Moreover, recently proposed attribution models show suboptimal performance in non-focal manifestations. We employed multidisciplinary assessment tailored to each case and NP manifestation for attribution,6 47 and similar approaches have been used by others 48. We have also recently cross-checked our judgement with existing attribution models 6 49.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychiatric lupus or not? Cerebral hypoperfusion by perfusion-weighted MRI in normal-appearing white matter in primary neuropsychiatric lupus erythematosus

Papadaki

Fanouriakis

Kavroulakis

et al. 2018

Annals of the Rheumatic Diseases

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Section: Discussionmentioning

confidence: 99%

Neuropsychiatric lupus or not? Cerebral hypoperfusion by perfusion-weighted MRI in normal-appearing white matter in primary neuropsychiatric lupus erythematosus

Papadaki

Fanouriakis

Kavroulakis

et al. 2018

Annals of the Rheumatic Diseases

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“…A multidisciplinary consensus meeting took place soon after the evaluation of every patient. For further description of the multidisciplinary evaluation, please see Zirkzee et al 21 All patients were classified according to the American College of Rheumatology (ACR) 1982 revised criteria for the classification of SLE. 22,23 Clinical disease activity was measured by the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K).…”

Section: Patient Selection and Clinical Evaluationmentioning

confidence: 99%

Complement levels and anti-C1q autoantibodies in patients with neuropsychiatric systemic lupus erythematosus

Magro-Checa

Schaarenburg

Beaart

et al. 2016

Lupus

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Objective: The objective of this paper is to analyse serum levels of anti-C1q, C1q circulating immune complexes (CIC), complement activation and complement components in systemic lupus erythematosus (SLE) patients during the first central nervous system neuropsychiatric (NP) event and to define the possible association between these results and clinical and laboratory characteristics. Methods: A total of 280 patients suspected of having NP involvement due to SLE were recruited in the Leiden NPSLE-clinic. All SLE patients were classified according to the ACR 1982 revised criteria for the classification of SLE. The clinical disease activity was measured by the SLE Disease Activity Index 2000 (SLEDAI-2K) and NP diagnoses were classified according to the 1999 ACR case definitions for NPSLE. We measured in serum of all patients anti-C1q and C1q CIC levels, the activation capacity of complement (CH50 and AP50) and different complement components (C1q, C3, C4). Results: In 92 patients the symptoms were attributed to SLE. NPSLE patients consisted of 63 patients with focal NPSLE and 34 patients with diffuse NPSLE. Anti-C1q antibodies were significantly higher and CH50, AP50 and C3 were significantly lower in NPSLE patients compared with SLE patients without NPSLE. This association was specially marked for diffuse NPSLE while no differences were found for focal NPSLE. After using potential predictors, decreased C4 remained significantly associated with focal NPSLE, but only when antiphospholipid antibodies (aPL) were included in the model. C3 and AP50 were independently associated with diffuse NPSLE. When SLEDAI-2K was included in the model these two associations were lost. When individual NPSLE syndromes were analysed, psychosis and cognitive dysfunction showed significantly lower values of complement activation capacity and all complement components. No significant associations were seen for other individual NPSLE syndromes. Conclusion: The associations between diffuse NPSLE and anti-C1q, C3/AP50 and focal NPSLE and C4 may be explained by disease activity and the presence of aPL, respectively. The role of complement activation and complement components in lupus psychosis and cognitive dysfunction merits further research. Lupus (2016) 25, 878-888.

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“…While most of the studies were of a retrospective design, 4 studies, contributing with 2447 patients were prospective 27,31,36,60 .…”

Section: Literature Search Strategy and Articles Retrievedmentioning

confidence: 99%

Autoantibodies involved in neuropsychiatric manifestations associated with systemic lupus erythematosus: a systematic review

et al. 2014

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Prospective Study of Clinical Phenotypes in Neuropsychiatric Systemic Lupus Erythematosus; Multidisciplinary Approach to Diagnosis and Therapy

Cited by 65 publications

References 43 publications

Neuropsychiatric lupus or not? Cerebral hypoperfusion by perfusion-weighted MRI in normal-appearing white matter in primary neuropsychiatric lupus erythematosus

Neuropsychiatric lupus or not? Cerebral hypoperfusion by perfusion-weighted MRI in normal-appearing white matter in primary neuropsychiatric lupus erythematosus

Complement levels and anti-C1q autoantibodies in patients with neuropsychiatric systemic lupus erythematosus

Autoantibodies involved in neuropsychiatric manifestations associated with systemic lupus erythematosus: a systematic review

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