Prospective Study of Diet and Decline in Lung Function in a General Population

McKeever, Tricia M.; Scrivener, Sarah; Broadfield, Emma; Jones, Zoe; Britton, John; Lewis, Sarah

doi:10.1164/rccm.2109030

Cited by 106 publications

(89 citation statements)

References 29 publications

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“…Observational studies have reported beneficial effects of a higher intake of fruit on adult lung function [36][37][38][39][40], incident COPD risk [41] and COPD mortality [42], and of a higher intake of whole grains on lung function [36] and lower mortality from chronic respiratory disease [43]. Many studies have found a positive association between vitamin C intake and adult lung function [44][45][46][47][48][49] and there is some evidence in support of flavonoids [50]. The lack of benefit of vitamin supplementation on lung function and hospital admissions for COPD [8] may indicate that observational associations with vitamin C intake were confounded [51], either by other nutrients or by non-dietary lifestyle factors.…”

Section: Discussionmentioning

confidence: 99%

The relationship of dietary patterns with adult lung function and COPD

Shaheen¹,

Jameson²,

Syddall³

et al. 2010

Eur Respir J

133

113

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Previous studies of diet and lung function have focused on associations with individual nutrients and foods, and not dietary patterns.The relationships between dietary patterns and lung function and spirometrically defined chronic obstructive pulmonary disease (COPD) were investigated in 1,551 males and 1,391 females in Hertfordshire, UK. Dietary information was obtained by food frequency questionnaire and dietary patterns were identified using principal components analysis.Using regression analysis, after controlling for confounders, a ''prudent'' pattern (high consumption of fruit, vegetables, oily fish and wholemeal cereals) was positively associated with forced expiratory volume in 1 s (FEV1) (trend p-value ,0.001 in males, 0.008 in females) (difference in FEV1 between top and bottom quintiles of pattern score, 0.18 L (95% CI 0.08-0.28 L) in males, 0.08 L (95% CI 0.00-0.16 L) in females). This pattern was also positively associated with forced vital capacity (FVC) in both sexes. Males with a higher ''prudent'' pattern score had a higher FEV1/FVC (trend p-value 0.002) and a lower prevalence of COPD (odds ratio comparing top versus bottom quintile 0.46, 95% CI 0.26-0.81; trend p-value 0.012). Associations in males were stronger in smokers than nonsmokers (interaction p-value for FEV1/FVC 0.002).A ''prudent'' dietary pattern may protect against impaired lung function and COPD, especially in male smokers.

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Section: Discussionmentioning

confidence: 99%

The relationship of dietary patterns with adult lung function and COPD

Shaheen¹,

Jameson²,

Syddall³

et al. 2010

Eur Respir J

133

113

View full text Add to dashboard Cite

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“…Presumably, a reduction of VC in the lungs resulted in an enlargement of the air space without alveolar destruction, but complete lack of VC in the lungs generated pulmonary emphysema. Several epidemiologic studies indicate that dietary factors, particularly VC, may be involved in the etiology of COPD (31,41,44). A prospective study of dietary intake of antioxidant vitamins (vitamins A, C, and E) and decline of lung function performed in a general population consisting of 2,663 adults aged 18 -70 living in the United Kingdom identified a significant correlation between declining lung function and intake of VC but not vitamins A or E (31).…”

Section: Discussionmentioning

confidence: 99%

Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice

Koike

Kondo

Sekiya

et al. 2010

American Journal of Physiology-Lung Cellular and Molecular Phys

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Vitamin C (VC) is a potent antioxidant and plays an essential role in collagen synthesis. As we previously reported, senescence marker protein-30 (SMP30) knockout (KO) mice cannot synthesize VC due to the genetic disruption of gluconolactonase (i.e., SMP30). Here, we utilized SMP30 KO mice deprived of VC and found that VC depletion caused pulmonary emphysema due to oxidative stress and a decrease of collagen synthesis by the third month of age. We grew SMP30 KO mice and wild-type (WT) mice on VC-free chow and either VC water [VC(ϩ)] or plain water [VC(Ϫ)] after weaning at 4 wk of age. Morphometric findings and reactive oxygen species (ROS) in the lungs were evaluated at 3 mo of age. No VC was detected in the lungs of SMP30 KO VC(Ϫ) mice, but their ROS increased 50.9% over that of the VC(ϩ) group. Moreover, their collagen content in the lungs markedly decreased, and their collagen I mRNA decreased 82.2% compared with that of the WT VC(Ϫ) group. In the SMP30 KO VC(Ϫ) mice, emphysema developed [21.6% increase of mean linear intercepts (MLI) and 42.7% increase of destructive index compared with VC(ϩ) groups], and the levels of sirtuin 1 (Sirt1) decreased 16.8%. However, VC intake increased the MLI 16.2% and thiobarbituric acid reactive substances 22.2% in WT mice, suggesting that an excess of VC can generate oxidative stress and may be harmful during this period of lung development. These results suggest that VC plays an important role in lung development through affecting oxidant-antioxidant balance and collagen synthesis. chronic obstructive pulmonary disease; collagen VITAMIN C (VC) is a water-soluble, hexonic sugar acid that has two dissociable protons (40) and is abundant in fluids of the lung epithelial lining (50). VC scavenges free radicals such as superoxide (34), singlet oxygen (4), and hydroxyl radicals (2). Several reports indicate that VC has a beneficial effect on lung function but, when depleted during aging, may promote chronic obstructive pulmonary disease (COPD; Refs. 41, 44). On the other hand, VC also plays an essential role in collagen synthesis because it acts as a cofactor for prolyl hydroxylase to catalyze hydroxyproline synthesis, which is involved in collagen helix stabilization (33, 38). Furthermore, VC stimulates collagen biosynthesis not only by promoting the activity of the prolyl hydroxylase, but also by increasing the mRNA of collagen (I and III; Refs. 13,35).Senescence marker protein-30 (SMP30) is characterized by its ever-decreasing content in the liver, kidney, and lung with aging, a decrease that is androgen-independent (11). To clarify the physiological role of SMP30 in age-associated organ disorders, we used gene targeting to establish the SMP30 knockout (KO) mouse from C57BL/6 mice (17). Recently, we (24) reported that SMP30 has gluconolactonase (GNL) activity. Since GNL is a key enzyme in the VC biosynthetic pathway of mammals, mice deprived of GNL (SMP30 KO mice) lack the ability to synthesize VC (19). We (42) further discovered that oxidative stress is greater in the lungs o...

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“…These include diet and physical activity. Recent studies report that antioxidants reduce the rate of loss of lung function [24,25] and physical inactivity, such as high daily televisionviewing hours, are associated with lower lung function [9].…”

Section: Discussionmentioning

confidence: 99%

Area deprivation predicts lung function independently of education and social class

Shohaimi¹,

Welch²,

Bingham³

et al. 2004

Eur Respir J

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The cross-sectional association between socioeconomic status (at both the individual and area-based level) and lung function, as measured by forced expiratory volume in one second, in a large population-based cohort was investigated.The study population consisted of 22,675 males and females aged 39-79 yrs. They were recruited from the general community in Norfolk, UK using general practice age/sex registers, as part of the European Prospective Investigation into Cancer (EPIC-Norfolk).It was found that being in a manual occupational social class, having no educational qualifications and living in a deprived area all independently predicted significantly lower lung function, even after controlling for smoking habit.The influence of area-deprivation on lung function, independent of individual socioeconomic status and of individual smoking habit, suggests that apart from targeting individuals who are at high-risk, such as smokers, environmental determinants also need to be examined when considering measures to improve respiratory health. Socioeconomic differentials in health are well-established. Individuals of lower socioeconomic status have a higher risk of mortality and morbidity compared to those of higher socioeconomic status [1]. Much of the research, however, has concentrated on mortality and morbidity from cardiovascular diseases [2,3] and cancer [4,5]. Less is known about the association between socioeconomic status and respiratory diseases and lung function. Recent studies have shown that poor lung function measured by forced expiratory volume in one second (FEV1) is a strong predictor of mortality from cardiovascular diseases, stroke and lung cancer [6][7][8] independent of smoking. The nature of the relationship between FEV1 and mortality is not well understood. It is possible that both may be a result of common factors, such as cigarette smoking, physical inactivity [9] and obesity [10, 11] which could be linked to socioeconomic status.Several studies have investigated the association between socioeconomic status and respiratory diseases. PRESCOTT et al.[12], for example, reported that socioeconomic status affects the risk of developing chronic obstructive pulmonary diseases, while HOLE et al. [6] found that those with higher relative FEV1 were less likely to be in social class IV or V. Another study found that manual workers had significantly worse lung function compared to nonmanual workers [13]. Most of these studies, however, mainly used individual-based measures of socioeconomic status. It has been suggested that in order to encompass the full extent of socioeconomic influences, the use of both individual and area-based measures of socioeconomic status is required [3]. This study reports the cross-sectional investigation into the association between respiratory function as measured by FEV1 and socioeconomic status at both the individual and area-based level, in a large population-based cohort. MethodsThe study population comprises males and females aged 39-79 yrs who were identified from ...

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Prospective Study of Diet and Decline in Lung Function in a General Population

Cited by 106 publications

References 29 publications

The relationship of dietary patterns with adult lung function and COPD

The relationship of dietary patterns with adult lung function and COPD

Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice

Area deprivation predicts lung function independently of education and social class

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