Prospective study of enteropathogens in children with diarrhea in Houston and Mexico

Pickering, Larry K.; Evans, Doyle J.; Muñoz, Onofre; DuPont, Herbert L.; Coello-Ramírez, P; Vollet, John J.; Conklin, Richard H.; Olarte, J; Kohl, Steve

doi:10.1016/s0022-3476(78)81142-1

Cited by 84 publications

(22 citation statements)

References 29 publications

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“…The type of agents found was similar to those isolated in previous transversal studies carried out during the 1970s in hospitals in Mexico City (Donta et al 1977;Pickering et al 1978). In these hospital studies the frequency of isolation of rotavirus and shigella was much higher than in the present community-based investigation.…”

Section: Discussionsupporting

confidence: 88%

Prospective study of diarrhoeal disease in a cohort of rural Mexican children: incidence and isolated pathogens during the first two years of life

Cravioto¹,

Reyes²,

Ortega³

et al. 1988

Epidemiol. Infect.

137

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SUMMARYColonization of the intestine by putative pathogens was followed longitudinally in a cohort of 56 infants born during one calendar year in a rural Mexican village with faecal cultures taken every fortnight and every time a child had diarrhoea. The frequency of isolation of pathogens during episodes of diarrhoea was compared with that of matched controls from the same cohort. Incidence of diarrhoea during the first year of life was 98%, diminishing to 93% during the second year. The incidence curves for each year were not significantly different (P > 041). Isolation of enteropathogenic Escherichia coli, enterotoxigenic Escherichia coli producing heat-stable (ST) and/or heat-labile (LT) enterotoxins and rotaviruses was significantly higher in infants with diarrhoea during the first 2 years of life. In the case of shigella, although no significant differences were found by semester of life, 13 of 16 children in which these strains were found had diarrhoea. Isolation of Salmonella spp., Campylobacter spp. and protozoa were not significantly different in the two groups during the period studied. Strains showing localized adherence to HEp-2 cells or the presence of colonization factor antigens I or E8775 were found with significantly higher frequency in children with diarrhoea. Eighty-two percent of ST' or LT' ETEC strains isolated produced one of the three known colonization factors.

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Section: Discussionsupporting

confidence: 88%

Prospective study of diarrhoeal disease in a cohort of rural Mexican children: incidence and isolated pathogens during the first two years of life

Cravioto¹,

Reyes²,

Ortega³

et al. 1988

Epidemiol. Infect.

137

View full text Add to dashboard Cite

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“…After the publication of Bishop et al (1973), showing the presence of rotavirus-like particles in stools of infants with acute gastrAnteritis, many publications have shown considerable evidence that this virus is the aetiologic agent involved in a large proportion ofthe diarrhoea of infants and children (Albrey & Murphy, 1976;Hieber et al 1978;Pickering et al 1978). Rotavirus has also been shown to occur in adults (WHO, 1981;Bonsdorff et at.…”

Section: Discussionmentioning

confidence: 99%

An outbreak of gastroenteritis caused by both rotavirus andShigella sonneiin a private school in Rio de Janeiro

Sutmoller

Azeredo

Lacerda

et al. 1982

J. Hyg.

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SUMMARYIn May 1980 an extensive outbreak ofgastroenteritis occurred in a private school in the city of Rio de Janeiro. Examination of faeces and paired sera showed that this outbreak was caused by both rotavirus and a virulent strain of Shigella sonnei.In the first 19 stool samples collected seven (37 %) had rotavirus only, six (32 %) had Sh. sonnei only, while four (21 %) had both agents. Examination of the second and third stool collections revealed only the presence of Sh. sonnei. The 18 paired sera showed seroconversion for rotavirus in four cases (22 %) and in seven cases (39 %) for Sh. sonnei. The overall attack rate ofthe disease was approximately 75 %, the nursery and kindergarten having higher attack rates. Students in all grades became sick at the same time, and the unimodal curve of the onset dates of symptoms indicates a common source outbreak. Evidence suggested a contaminated water supply.

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“…Bacterial intestinal pathogens and rotaviruses can be isolated from or demonstrated in most children and adults with acute diarrhoea coming to hospital in tropical developing countries (Maiya et al, 1977;Pickering et al, 1978;Hieber et al, 1978;Black et al, 1980;Mata et al, 1983;Sen et al, 1983). The human habitat in such countries is insanitary; water supplies are unprotected, waste disposal is inadequate, and there is close association between man and domestic animals.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Bacterial Intestinal Pathogens in a Healthy Rural Population in Southern India

Mathan

Rajan

1986

Journal of Medical Microbiology

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Summary. In a one-year prospective survey bacterial intestinal pathogens unassociated with diarrhoeal episodes were isolated from 20.5% of stool samples from 48.5% of a stratified random sample of the population of a village in southern India. Campylobacter jejuni was the pathogen most frequently isolated, followed by enteropathogenic serotypes of Escherichia coli. The incidence of diarrhoea in the study population was lower than the frequency of isolation of bacterial intestinal pathogens. It is necessary to understand the prevalence of intestinal pathogens in this ecosystem to know the dynamics of intestinal infection and the pathogenesis of diarrhoea.

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Prospective study of enteropathogens in children with diarrhea in Houston and Mexico

Cited by 84 publications

References 29 publications

Prospective study of diarrhoeal disease in a cohort of rural Mexican children: incidence and isolated pathogens during the first two years of life

Prospective study of diarrhoeal disease in a cohort of rural Mexican children: incidence and isolated pathogens during the first two years of life

An outbreak of gastroenteritis caused by both rotavirus andShigella sonneiin a private school in Rio de Janeiro

The Prevalence of Bacterial Intestinal Pathogens in a Healthy Rural Population in Southern India

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