Prospective Study of Infantile Hemangiomas: Demographic, Prenatal, and Perinatal Characteristics

Haggstrom, Anita N.; Drolet, Beth A.; Baselga, Eulàlia; Chamlin, Sarah L.; Garzon, María C.; Horii, Kimberly A.; Lucky, Anne W.; Mancini, Anthony J.; Metry, Denise; Newell, Brandon; Nopper, Amy J.; Frieden, Ilona J.

doi:10.1016/j.jpeds.2006.12.003

Cited by 420 publications

(357 citation statements)

References 11 publications

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“…Demographic and baseline characteristics met the expected population profile observed in previous studies 17,24 : patients were predominantly girls (33 of 45; 73%) and had facial IHs (35 of 45; 78%), and most IHs were localized (28 of 45; 62%). The mean largest diameter for the superficial component was 3.88 cm (SD 2.90 cm; range 0.1 to 12.5 cm), and the mean for the deep component was 3.49 cm (SD 3.09 cm; range 0.5 to 14.0 cm).…”

Section: Resultssupporting

confidence: 70%

Efficacy of Propranolol Between 6 and 12 Months of Age in High-Risk Infantile Hemangioma

et al. 2018

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BACKGROUND AND OBJECTIVES:There is no consensus on optimal treatment duration for propranolol in infantile hemangioma (IH). We evaluated the efficacy and safety of oral propranolol solution administered for a minimum of 6 months up to a maximum of 12 months of age in high-risk IH. METHODS:This single-arm, open-label, phase 3 study was conducted in patients aged 35 to 150 days with high-risk IH in 10 hospitals between 2015 and 2017. The study comprised a 6-month initial treatment period (ITP) plus continuation up to 12 months of age if complete success was not achieved, a follow-up, and a retreatment period. Patients received oral propranolol twice daily (3 mg/kg per day). The primary end point was the success rate at the end of the ITP. Furthermore, the persistence of IH response and efficacy of retreatment was evaluated. RESULTS:The success rate after 6 months of treatment was 47%, increasing to 76% at the end of the ITP. Of the patients who achieved success, 68% sustained success for 3 months without treatment, and 24% required retreatment. Of the 8 patients who were retreated, 7 achieved success. Adverse events, reported by 80% of patients, were mild, which were expected in this population or known propranolol side effects. CONCLUSIONS:Oral propranolol administered beyond 6 months and up to 12 months of age meaningfully increases the success rate in high-risk IH. Success was sustained in most patients up to 3 months after stopping treatment. Retreatment was efficacious, and the safety profile satisfactory.abstract

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Section: Resultssupporting

confidence: 70%

Efficacy of Propranolol Between 6 and 12 Months of Age in High-Risk Infantile Hemangioma

et al. 2018

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“…Es más habitual en el sexo femenino en proporción 3:1 y en la raza blanca, como ocurre en nuestro caso. 5 Se produce por proliferación de las células endoteliales de los vasos sanguíneos.…”

Section: Discussionunclassified

Hemangioma mamario en una lactante con aparente mastitis. Caso clínico

Jiménez

Navarro

Domínguez

et al. 2018

Arch Argent Pediatr

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Presentación de casos clínicos RESUMENLa patología mamaria en pediatría es infrecuente. El hallazgo de una masa a nivel mamario en un lactante es una situación poco común. Los posibles diagnósticos a esta edad son absceso mamario, mastitis, ingurgitación mamaria por estimulación hormonal materna y hemangioma. Es importante llegar al diagnóstico adecuado para emplear un tratamiento acorde y evitar la aparición de complicaciones de dichas patologías. Se presenta un caso de una lactante con una masa en la mama derecha detectada desde el nacimiento. Inicialmente, se trató como una mastitis, pero dada la mala evolución, se plantearon diagnósticos diferenciales y se concluyó que se trataba de un hemangioma. Debido a la ulceración de la lesión, junto con el riesgo existente de desarrollar hipoplasia mamaria, se decidió iniciar tratamiento con propanolol, con resolución casi completa de la tumoración. Palabras clave: hemangioma infantil, enfermedades de la mama, úlcera, propanolol. ABSTRACTMammary pathology is infrequent during childhood. It is rare the probability of finding a breast mass in an infant. The most frequent possible diagnoses at this age are breast abscess, mastitis, breast engorgement due to maternal hormonal stimulation and hemangioma. Reaching the proper diagnosis is essential in order to apply a suitable treatment and avoid the potential disease complications. We present the case of a female infant having a mass in the right breast from birth. Initially the entity was treated as mastitis. Nevertheless, the bad evolution made necessary considering the differential diagnosis. It was concluded to be a hemangioma. Due to the lesion ulceration and the potential risk of developing breast hypoplasia, treatment with propranolol was started. The tumor was almost completely resolved.

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“…Higher risk is associated with several well‐known factors, comprising female sex, prematurity, multiple gestation and white, non‐Hispanic background 11. So far, case reports of patients with IH with NF1 have been little reported, except for two case reports 12, 13.…”

Section: Discussionmentioning

confidence: 99%

Novel mutations in one allele in a Chinese family with neurofibromatosis type 1: Including a complex insertion–deletion mutation

Zhu

Shi

Wang

et al. 2016

The Journal of Dermatology

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Neurofibromatosis type 1 (NF1) is a hereditary disease with variable clinical manifestations. This study was performed in a Chinese three‐generation family containing two members with NF1. Two novel mutations, c.853_854insTC and c.1975_1976delinsTA, were identified in the same allele in both patients by direct sequencing. By reverse transcription polymerase chain reaction, we found that the NF1 transcript contained the first mutation instead of the second mutation, suggesting a pathological role of c.853_854insTC mutation. Case reports of patients with two NF1 mutations in the same allele have not been reported. Our findings expand the known spectrum of NF1 mutations and the ongoing recognition of different mutations may give insight into the mysterious NF1 pathogenesis.

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Prospective Study of Infantile Hemangiomas: Demographic, Prenatal, and Perinatal Characteristics

Cited by 420 publications

References 11 publications

Efficacy of Propranolol Between 6 and 12 Months of Age in High-Risk Infantile Hemangioma

Efficacy of Propranolol Between 6 and 12 Months of Age in High-Risk Infantile Hemangioma

Hemangioma mamario en una lactante con aparente mastitis. Caso clínico

Novel mutations in one allele in a Chinese family with neurofibromatosis type 1: Including a complex insertion–deletion mutation

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