Prospective study of infective endocarditis from a developing country

Math, Ravi S.; Sharma, Gautam; Kothari, Shyam Sunder; Kalaivani, Mani; Saxena, Anitá; Kumar, Arkalgud Sampath; Bahl, Vinay K.

doi:10.1016/j.ahj.2011.07.014

Cited by 62 publications

(89 citation statements)

References 19 publications

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“…Staphylococcus accounts for 15-50% of cases with Staphylococcus aureus more common than coagulase negative Staphylococcus (CoNS). [19][20][21][22][23]25,31,32,34 Comparison with pre-millennial ranges shows an increase in Staphylococcus which was previously reported in less than 20% of cases. 11,13,28 The emergence of Staphylococcus as a leading cause of IE in LMICs, a trend that was also previously noted in HICs, may reflect medical technology advances, increased hospital contact and increasing comorbidities.…”

Section: Staphylococcusmentioning

confidence: 63%

“…[19][20][21][22][23][24] Nel et al 25 however, reported a much higher (78%) prevalence of underlying RHD in their study in South Africa, a country where RHD is endemic. 26 Overall, this range of underlying RHD in IE represents a decline from the 45-80% reported in earlier (pre-2000) LMIC studies.…”

Section: Underlying Cardiac Conditionsmentioning

confidence: 78%

“…[19][20][21][22][23]31,32 UMIC studies account for the higher figures in these ranges, which reflects advances in medical technology and higher access to cardiac surgery. 21,22 Indeed, the largest report of PVE cases from a LMIC comes from Simsek-Yavuz et al 21 who reported findings from a referral centre in Turkey (an UMIC) in which 141 patients (44%) among 325 IE cases had PVE.…”

Section: Underlying Cardiac Conditionsmentioning

confidence: 99%

“…[19][20][21][22][23]25,31,32,34 Streptococcus is common among younger patients, patients with community-acquired IE and patients with rheumatic or congenital NVE. 19,20,34 This finding was highlighted by Simsek-Yavuz et al 21 in a study in Turkey where although Staphylococcus was the leading cause of IE in the entire cohort, Streptococcus was significantly more prevalent among patients with a native valve, patients less than 40 years of age, and patients with community-acquired IE.…”

Section: Streptococcusmentioning

confidence: 99%

“…37,41 Our reviewed studies reveal high usage of combination therapy that typically includes beta-lactams or peptide antibiotics and aminoglycosides, with prolonged duration of therapy ranging between 35-67 days. 20,43 Mean duration of hospital stay ranges between 16-38 days. 21,22,34,43 Outpatient parenteral antibiotic therapy (OPAT) may be considered in stable patients to decrease hospital stay.…”

Section: Medical Therapymentioning

confidence: 99%

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Infective Endocarditis in Low- and Middle-Income Countries

et al. 2017

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Key Points Staphylococcus is an increasingly important cause of IE in LMICs, and is the leading cause of IE in UMICs  RHD remains the major underlying cardiac pathology of IE in LMICs, identified in almost half of reported cases  The rate of microorganism non-identification is high, reaching up to 60% of IE cases in LMICs, and hampering diagnosis and treatment  Rates of access to surgery in UMICs for complicated IE are as high as in HICs, but remain dismal in lower-middle income countries SynopsisInfective endocarditis (IE) is a rare, life-threatening disease with a mortality rate of upto 25% and significant debilitating morbidities. Although much has been reported on contemporary IE in high income countries, conclusions on the state of IE in low and middle income countries (LMICs) are based on studies conducted before the year 2000. Furthermore, unique challenges in the diagnosis and management of IE persist in LMICs. This article is a review of IE studies conducted in LMICs documenting clinical experiences from the year 2000 to present. We present the causes of IE, management of patients with IE and the prevailing challenges in diagnosis and treatment of IE in LMICs.

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Section: Staphylococcusmentioning

confidence: 63%

Section: Underlying Cardiac Conditionsmentioning

confidence: 78%

Section: Underlying Cardiac Conditionsmentioning

confidence: 99%

Section: Streptococcusmentioning

confidence: 99%

Section: Medical Therapymentioning

confidence: 99%

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Infective Endocarditis in Low- and Middle-Income Countries

et al. 2017

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Infectious Disease Imaging

Lungren

Peper²,

Ordoñez

et al. 2014

Radiology in Global Health

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Maternal Understanding of Infective Endocarditis After Hospitalization: Assessing the Knowledge of Mothers of Children with Congenital Heart Disease and the Practical Implications

2013

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This study aimed to examine the knowledge of mothers of children with congenital heart disease as well as the association of cardiological factors and maternal characteristics with maternal understanding. Mothers of 135 children (≤2 years old) were interviewed to assess maternal knowledge of infective endocarditis (IE) using the Hannover Inventory of Parental Knowledge of Congenital Heart Disease. Two subscales, endocarditis and risk factors, were used. Cardiological data as well as maternal characteristics were collected. Two-thirds of the mothers achieved only low scores, answering 0-20 % of the questions correctly (endocarditis = 64.4 %; risk factors = 71.1 %). Mothers with higher education recalled the correct definition of IE (P = 0.001) and the importance of dental hygiene (P = 0.004) more often. Mothers with only one child were more likely to know the most typical symptom (P = 0.007). The severity of the heart disease and the requirement of endocarditis prophylaxis did not influence maternal understanding. Yet, mothers assessing the heart disease as severe showed better knowledge (typical symptom P = 0.021; importance of dental hygiene P = 0.007). If mothers learned the diagnosis before their child's birth, they remembered relevant information more often. Mothers receiving information by the medical staff and from the Internet showed better knowledge (definition P = 0.014; importance of dental hygiene P = 0.001). Due to low levels of knowledge, more efforts must be put into the education of mothers. Educational programs should take maternal characteristics into account, providing written material and thereby keeping the instruction of lower-educated persons in mind. Furthermore, education should be focused on mothers of children requiring IE prophylaxis.

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Prospective study of infective endocarditis from a developing country

Cited by 62 publications

References 19 publications

Infective Endocarditis in Low- and Middle-Income Countries

Infective Endocarditis in Low- and Middle-Income Countries

Infectious Disease Imaging

Maternal Understanding of Infective Endocarditis After Hospitalization: Assessing the Knowledge of Mothers of Children with Congenital Heart Disease and the Practical Implications

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