Prospective study on comparison of efficacy of topical anti-fungal agents: clotrimazole 1% and sertaconazole 2% in treatment of tinea cruris

Lakhani, Som J.; Joshi, Dhaval B.; Kumbhani, Kalindi R.; Hadia, Rajesh

doi:10.18203/issn.2455-4529.intjresdermatol20195672

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…[ 1 ] According to site, these infections are classified as tinea pedis (feet), tinea corporis (body), tinea cruris (groin), and so on. [ 2 ] It has high prevalence in country like India where prevalence ranges from 36.6% to 78.4%. [ 3 ] Tropical climate characterized by high humidity and varying degree of temperature with low socioeconomic status and conditions such as overcrowding, poor personal hygiene are the various risk factors contributing toward increasing prevalence of disease in India.…”

Section: Introductionmentioning

confidence: 99%

“…Dermatophytosis also known as ring worm infection is characterized by the erythematous scaly plaques giving it a ring like morphology and is associated with intense pruritis. [ 2 ] Direct microscopic examination is done for the diagnosis of the fungal infection where 10% potassium hydroxide mount is prepared from the skin scrapings. [ 6 ] The treatment of dermatophytosis demands the use of topical or systemic antifungal therapy depending on the site and extent of involvement.…”

Section: Introductionmentioning

confidence: 99%

“…[ 7 ] However, systemic therapy is required in the severe cases of dermatophytosis. [ 2 ] Clotrimazole and luliconazole are the imidazole antifungal drugs being commonly used in the skin outpatient department (OPD) for the treatment of localized dermatophytosis. Clotrimazole is one of the oldest known broad spectrum topical antifungal agent that requires twice daily application.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy, safety, and cost evaluation of the topical luliconazole therapy versus topical clotrimazole therapy in patients with localized dermatophytosis in a tertiary care hospital: An observational study

Kaur

Gupta

Mahajan

et al. 2020

Int J App Basic Med Res

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Background: Dermatophytosis is a superficial fungal infection that has high affinity for keratinized tissues of the body. The treatment of localized dermatophytosis is a major concern for the dermatologist especially in tropical countries like India. Various topical antifungals are available for the treatment of localized uncomplicated dermatophytosis. Luliconazole is an azole antifungal available that has potent activity against dermatophytes. Objectives: The objective of this study was to compare two treatment modalities for the treatment of localized dermatophytosis in terms of efficacy, safety, and cost evaluation. Materials and Methods: This was a prospective and observational study carried out for 6 months and included 200 patients (luliconazole group [ n = 94] and clotrimazole group [ n = 106]). Patients were followed up for 2, 4, and 6 weeks. Outcome parameters such as pruritis, erythema, scaling, vesiculations, and global assessment score were noted at 2, 4, and 6 weeks for the assessment of efficacy. The statistical analysis was done using Chi-square and Student's t -test. Results: Luliconazole and clotrimazole showed 56.38% and 23.58% cure rate at the end of two weeks respectively ( P < 0.05). At the end of treatment, the cure rates were 98.93% and 95.28% in luliconazole and clotrimazole, respectively ( P > 0.005). Both the drugs were equally safe. On cost-effective analysis, luliconazole was found to be more cost-effective than clotrimazole at the end of 2 weeks. Conclusion: Therapeutic efficacy of luliconazole was more as significant proportion of patients achieved complete clearance of lesions at faster rate within 2 weeks with convenient once daily application.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy, safety, and cost evaluation of the topical luliconazole therapy versus topical clotrimazole therapy in patients with localized dermatophytosis in a tertiary care hospital: An observational study

Kaur

Gupta

Mahajan

et al. 2020

Int J App Basic Med Res

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“…At least 50% of patients with scaling were completely relieved and erythema and itching subsided to either mild intensity or was completely relieved by the end of 3rd week of treatment; similar to results observed in studies conducted by Shivamurthy et al and Lakhani et al At 3rd week of treatment significant proportion of patients achieved total signs and symptoms score ≤2, suggesting that appropriate treatment and patient compliance play a major role in good prognosis. 10,29,30 Eberconazole 1% cream was found to be extremely tolerable and safe for the treatment of Tinea corporis and Tinea cruris in the Indian population with only 1 AE (fever of mild intensity, unrelated to the study drug). The safety profile was consistent with other comparative study in Indian patients.…”

Section: Discussionmentioning

confidence: 94%

Effectiveness and safety of eberconazole 1% cream in Indian patients with Tinea corporis and Tinea cruris: a prospective real-world study

Thomas¹,

Das

Ghate³

et al. 2020

Int J Res Dermatol

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Background: Tinea corporis and cruris are estimated to affect 22% to 55% of the Indian population. This real-world study was conducted to evaluate the effectiveness and safety of eberconazole 1% cream among Indian patients.Methods: In this prospective, single-arm, observational study, patients with Tinea corporis and cruris aged ≥18 years were prescribed eberconazole 1% cream (Ebernet®, Dr. Reddy’s Laboratory, India) for up to 3 weeks. The primary endpoint was proportion of patients with improvement in total signs and symptoms score with 2 weeks of treatment. The key secondary endpoint was mean percent reduction in individual signs and symptoms score (erythema, itching, scaling) from baseline to the end of the 1st, 2nd, and 3rd week. A post-hoc analysis was performed on a subgroup of patients (completer set [CS]) who reported application of eberconazole 1% cream for 3 weeks in the study. There were no adverse effects reported.Results: Of 120 enrolled patients;104 (86.7%) were included in the full analysis set (FAS) and 76 (63.3%) patients were included in the CS. After 2 weeks of treatment, total signs and symptoms score<2 was achieved by 25% of patients in the FAS and 28.9% in the CS. After 3 weeks of treatment, mean percent reduction in total sign and symptom score was 60.3% for erythema, 61.2% for itching, and 76.8% for scaling.Conclusions: The evidence from this real-world observational study and a post-hoc analysis suggests that eberconazole 1% cream is effective and safe treatment option in the management of Tinea corporis and cruris in Indian patients.

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A Prospective Observational Study on Anti-infective Agents in Adults in A Hospital

Kumar¹,

Reddy²,

Divya³

2021

IJPSRR

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The main aim of the pharmacist is to provide the right drug in the right quality at the right time to patient. The monitoring studies of such prescription pattern can nourish the relevant use and exploit or misuse of the drug which is monitored. The main goal of the present study is to ease the rational use of drugs and make awareness of the irrational use of the drug which is more prevalent to the drug resistance, economic burden to the patient and failure of the treatment. The present prospective observational study was going on the usage of anti-infective agents in the adults based on the prescription of the physician to the patients. Prescriptions were obtained from various clinical departments was done over the period of 6 months from October 2020 to March 2021 to assess the appropriate use of anti-infective agents in adults. Total 1610 prescriptions data of anti-infective agents were analysed of average range of medication includes antibacterial, antiviral, antifungal, anthelmintic, antiparasitic, antimicrobials. A total of 1610 prescriptions from out patient and in patient department of the hospital were analysed in this study and out of those patients, male patients were 714 (44.34%) and female patients were 896 (55.65%). The most common age group which was prescribed more antiinfective agents was 51-60 years. Among them the antibacterial were about 65.03%, antiviral 1.59%, antifungal 7.04%, anthelmintic 7.09%, antiparasitic 0.89%, antimicrobial 0.51%, antimalarial 0.93%, antitubercular 0.51%, Antibacterial+Antiprotozoal 16.45%. Now a days usage of anti-infective agents was high to improve the rational use of drugs and to avoid the irrational usage of antibiotics in increasing the side effects and resistance towards the drug and total cost of treatment as well.

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Prospective study on comparison of efficacy of topical anti-fungal agents: clotrimazole 1% and sertaconazole 2% in treatment of tinea cruris

Cited by 3 publications

References 9 publications

Efficacy, safety, and cost evaluation of the topical luliconazole therapy versus topical clotrimazole therapy in patients with localized dermatophytosis in a tertiary care hospital: An observational study

Efficacy, safety, and cost evaluation of the topical luliconazole therapy versus topical clotrimazole therapy in patients with localized dermatophytosis in a tertiary care hospital: An observational study

Effectiveness and safety of eberconazole 1% cream in Indian patients with Tinea corporis and Tinea cruris: a prospective real-world study

A Prospective Observational Study on Anti-infective Agents in Adults in A Hospital

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