Prospectives and retrospectives of microfluidics devices and lab-on-A-chip emphasis on cancer

Venkatesalu, Sneha; Dilliyappan, Shanmugapriya; Satish Kumar, Avanthika; Palaniyandi, Thirunavukkarasu; Baskar, Gomathy; Ravi, Maddaly; Sivaji, Asha

doi:10.1016/j.cca.2023.117646

Cited by 3 publications

(1 citation statement)

References 81 publications

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“…Originally, non-coding RNAs were interpreted as transcriptional noise [ 45 ]; however, the significant role played by these RNAs has been confirmed, both in biological mechanisms [ 46 , 47 ] and in the development of diseases, including cancer [ 48 , 49 ]. With the advancements and reduced costs in omics technologies, alongside the development of lab-on-chip devices, detecting changes in gene expression or mutations is becoming increasingly accessible and affordable [ 50 , 51 ].…”

Section: Emerging Molecular Markers For Thyroid Cancer: Opportunities...mentioning

confidence: 99%

Biomarkers in Thyroid Cancer: Emerging Opportunities from Non-Coding RNAs and Mitochondrial Space

Cabané,

Correa,

Bode

et al. 2024

IJMS

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Thyroid cancer diagnosis primarily relies on imaging techniques and cytological analyses. In cases where the diagnosis is uncertain, the quantification of molecular markers has been incorporated after cytological examination. This approach helps physicians to make surgical decisions, estimate cancer aggressiveness, and monitor the response to treatments. Despite the availability of commercial molecular tests, their widespread use has been hindered in our experience due to cost constraints and variability between them. Thus, numerous groups are currently evaluating new molecular markers that ultimately will lead to improved diagnostic certainty, as well as better classification of prognosis and recurrence. In this review, we start reviewing the current preoperative testing methodologies, followed by a comprehensive review of emerging molecular markers. We focus on micro RNAs, long non-coding RNAs, and mitochondrial (mt) signatures, including mtDNA genes and circulating cell-free mtDNA. We envision that a robust set of molecular markers will complement the national and international clinical guides for proper assessment of the disease.

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Section: Emerging Molecular Markers For Thyroid Cancer: Opportunities...mentioning

confidence: 99%

Biomarkers in Thyroid Cancer: Emerging Opportunities from Non-Coding RNAs and Mitochondrial Space

Cabané,

Correa,

Bode

et al. 2024

IJMS

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Enhancing mixing performance in a square electroosmotic micromixer through an off-set inlet and outlet design

Gayen,

Manna,

Biswas

2024

Physics of Fluids

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This study addresses the critical need to enhance mixing quality and cost efficiency in electroosmotic micromixers, crucial for various applications, such as chemical synthesis, medical diagnostics, and biotechnology, utilizing the precision of microfluidic devices. The intricate dynamics of time-dependent electroosmotic vortices induced by microelectrodes are investigated, exploring the nonlinear physics principles driving mixing enhancement. Specifically, an examination is made of how nonlinear phenomena, such as convective flow instabilities, chaotic advection, and nonlinear interactions between fluid flow and channel geometry, contribute to observed improvements in mixing performance. Through comprehensive numerical simulations employing finite element-based solvers, the impact of relevant parameters, such as voltage amplitude (V0), frequency (f), Reynolds number (Re), and Debye parameter (k), on mixing performance is systematically analyzed. Findings reveal that optimizing these parameters, coupled with the strategic design of micromixers featuring offset inlets and outlets, leads to a remarkable mixing quality of 98.44%. Furthermore, a methodology is proposed for selecting the optimal micromixer configuration (MM1), balancing mixing quality, and cost efficiency. This study advances the understanding of electroosmotic micromixers and provides practical guidelines for optimizing microfluidic device performance in diverse applications.

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Development of a Portable Residual Chlorine Detection Device with a Combination of Microfluidic Chips and LS-BP Algorithm to Achieve Accurate Detection of Residual Chlorine in Water

Wang,

Niu,

Pang

et al. 2024

Micromachines

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Chlorine is widely used for sterilization and disinfection of water, but the presence of excess residual chlorine in water poses a substantial threat to human health. At present, there is no portable device which can achieve accurate, rapid, low-cost, and convenient detection of residual chlorine in water. Therefore, it is necessary to develop a device that can perform accurate, rapid, low-cost, and convenient detection of residual chlorine in water. In this study, a portable residual chlorine detection device was developed. A microfluidic chip was studied to achieve efficient mixing of two-phase flow. This microfluidic chip was used for rapid mixing of reagents in the portable residual chlorine detection device, reducing the consumption of reagents, detection time, and device volume. A deep learning algorithm was proposed for predicting residual chlorine concentration in water, achieving precise detection. Firstly, the microfluidic chip structure for detecting mixed reagents was optimized, and the microfluidic chip was fabricated by a 3D-printing method. Secondly, a deep learning (LS-BP) algorithm was constructed and proposed for predicting residual chlorine concentration in water, which can realize dual-channel signal reading. Thirdly, the corresponding portable residual chlorine detection device was developed, and the detection device was compared with residual chlorine detection devices and methods in other studies. The comparison results indicate that the portable residual chlorine detection device has high detection accuracy, fast detection speed, low cost, and good convenience. The excellent performance of the portable residual chlorine detection device makes it suitable for detecting residual chlorine in drinking water, swimming pool water, aquaculture and other fields.

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Prospectives and retrospectives of microfluidics devices and lab-on-A-chip emphasis on cancer

Cited by 3 publications

References 81 publications

Biomarkers in Thyroid Cancer: Emerging Opportunities from Non-Coding RNAs and Mitochondrial Space

Biomarkers in Thyroid Cancer: Emerging Opportunities from Non-Coding RNAs and Mitochondrial Space

Enhancing mixing performance in a square electroosmotic micromixer through an off-set inlet and outlet design

Development of a Portable Residual Chlorine Detection Device with a Combination of Microfluidic Chips and LS-BP Algorithm to Achieve Accurate Detection of Residual Chlorine in Water

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