Prospects and Challenges towards Sustainable Liver Fluke Control

Sripa, Banchob; Echaubard, Pierre

doi:10.1016/j.pt.2017.06.002

Cited by 28 publications

(19 citation statements)

References 78 publications

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“…This work included designing and conducting research aimed at filling gaps in understanding environmental and ecological aspects of the parasite's transmission. More generally this resulted in broadening the understanding of the social and ecological dimensions of liver fluke transmission and its role in disease (44, 45).…”

Section: Case Examples From the Greater Mekong Subregionmentioning

confidence: 99%

Operationalizing One Health Employing Social-Ecological Systems Theory: Lessons From the Greater Mekong Sub-region

Wilcox

Aguirre

Paula³

et al. 2019

Front. Public Health

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The idea of the interdependency of the health of humans, animals, and ecosystems emerged from the interplay of theory and concepts from medicine, public health and ecology among leading thinkers in these fields during the last century. The rationale for One Health and its focus on the “human, animal, and environmental interface” stems from this legacy and points to transdisciplinary, ecological and complex systems approaches as central to One Health practice. Demonstration of One Health's efficacy, its wider adoption and continual improvement require explicit operational criteria and evaluation metrics on this basis. Social-Ecological Systems Theory with its unique conception of resilience (SESR) currently offers the most well-developed framework for understanding these approaches and development of performance standards. This paper describes operational criteria for One Health developed accordingly, including a protocol currently being tested for vector borne disease interventions. Wider adoption of One Health is most likely to occur as One Health practitioners gain an increasing familiarity with ecological and complex systems concepts in practice employing a transdisciplinary process. Two areas in which this inevitably will be required for significant further progress, and where the beginnings of a foundation for building upon exist, include: (1) Emerging and re-emerging zoonotic diseases, and (2) successful implementation of the United Nations (UN) Sustainable Development Goals (SDGs). The former includes the challenge of stemming the threat of new microbial pathogens, anti-microbial resistant variants of existing pathogens, as well as resurgence of malaria and other recalcitrant diseases. The applicability of SESR in this regard is illustrated with two case examples from the Greater Mekong Subregion, Avian Influenza (H5N1) and Liver Fluke ( Opisthorchis viverrini) . Each is shown to represent a science and policy challenge suggestive of an avoidable social-ecological system pathology that similarly has challenged sustainable development. Thus, SESR framing arguably is highly applicable to the SDGs, which, to a large extent, require consideration of human-animal-environmental health linkages. Further elaboration of these One Health operational criteria and metrics could contribute to the achievement of many of the SDGs.

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Section: Case Examples From the Greater Mekong Subregionmentioning

confidence: 99%

Operationalizing One Health Employing Social-Ecological Systems Theory: Lessons From the Greater Mekong Sub-region

Wilcox

Aguirre

Paula³

et al. 2019

Front. Public Health

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“…High-risk patients for the HCC group comprised those who had hepatitis virus B, hepatitis virus C infection, or both (HBV and HCV, respectively), alcoholic liver disease, and fatty liver disease, as these are factors that predispose individuals for HCC development (8). High-risk patients for the ICC group comprised those who had a known liver fluke infection, a factor associated with the development of ICC (9). Data were first evaluated for sufficient quality.…”

Section: Deregulated Metabolite Levels In the Tiger-lc Liver Cancer Cmentioning

confidence: 99%

“…Hepatitis B and C are the most common causes of chronic hepatitis in the world. For ICC, epidemiologic and experimental evidence strongly indicate that the liver fluke (Opisthorchis viverrini) is a major etiologic agent for this disease (9). Liver fluke is a fish-borne trematode endemic in Southeast Asia, including Thailand, where 10 million people are estimated to be infected (10).…”

Section: Introductionmentioning

confidence: 99%

Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma

Haznadar

Diehl

Parker

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Liver cancer is the second leading cause of cancer-related deaths worldwide. With a predicted 2.4-fold rise in liver cancer incidence by 2020, there is an urgent need for early, inexpensive diagnostic biomarkers to deploy in the clinic. Methods: We employed ultraperformance liquid chromatography tandem mass-spectrometry (UPLC/MS-MS) for the quantitation of four metabolites, creatine riboside (CR), N-acetylneuraminic acid (NANA), cortisol sulfate, and a lipid molecule designated as 561þ, in urine samples from the NCI-MD cohort comprising 98 hepatocellular carcinoma (HCC) cases, 101 high-risk subjects, and 95 controls. Validation was carried out in the TIGER-LC cohort [n ¼ 370 HCC and intrahepatic cholangiocarcinoma (ICC) cases, 471 high-risk subjects, 251 controls], where ICC, the second most common primary hepatic malignancy, is highly prevalent. Metabolite quantitation was also conducted in TIGER-LC tissue samples (n ¼ 48 ICC; n ¼ 51 HCC). Results: All profiled metabolites were significantly increased in liver cancer when compared with high-risk subjects and controls in the NCI-MD study. In the TIGER-LC cohort, the four-metabolite profile was superior at classifying ICC than a clinically utilized marker, CA19-9, and their combination led to a significantly improved model (AUC ¼ 0.88, P ¼ 4E-8). Metabolites CR and NANA were significantly elevated in ICC when compared with HCC cases in both urine and tissue samples. High levels of CR were associated with poorer prognosis in ICC. Conclusions: Four metabolites are significantly increased in HCC and ICC and are robust at classifying ICC in combination with the clinically utilized marker CA19-9. Impact: Noninvasive urinary metabolite biomarkers hold promise for diagnostic and prognostic evaluation of ICC.

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“…viverrini as well as a closely related species, Clonorchis sinensis , were classified as group I biological carcinogenic agents [1]. Opisthorchiasis is known to cause important public health problems in mainland Southeast Asia, particularly in Thailand, Lao PDR, Cambodia and Vietnam [2, 3]. The current transmission landscape consists of a light and uneven distribution of O .…”

Section: Introductionmentioning

confidence: 99%

Comparing the performance of urine and copro-antigen detection in evaluating Opisthorchis viverrini infection in communities with different transmission levels in Northeast Thailand

et al. 2019

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To combat and eventually eliminate the transmission of the liver fluke Opisthorchis viverrini , an accurate and practical diagnostic test is required. A recently established urine antigen detection test using monoclonal antibody-based enzyme-linked-immunosorbent assay (mAb-ELISA) has shown promise due to its high diagnostic accuracy and the use of urine in place of fecal samples. To further test the utility of this urine assay, we performed a cross sectional study of 1,043 people in 3 opisthorchiasis endemic communities in northeast Thailand by applying urine antigen detection together with copro-antigen detection methods. The quantitative formalin-ethyl acetate concentration technique (FECT) was concurrently performed as a reference method. The prevalence of O . viverrini determined by urine antigen detection correlated well with that by copro-antigen detection and both methods showed 10–15% higher prevalence than FECT. Within the fecal negative cases by FECT, 29% and 43% were positive by urine and copro-antigen detection, respectively. The prevalence and intensity profiles determined by antigen detection and FECT showed similar patterns of increasing trends of infection with age. The concentration of antigen measured in urine showed a positive relationship with the concentration of copro-antigen, both of which were positively correlated with fecal egg counts. The data observed in this study indicate that urine antigen detection had high diagnostic accuracy and was in concordance with copro-antigen detection. Due to the ease and noninvasiveness of sample collection, the urine assay has high potential for clinical diagnosis as well as population screening in the program for the control and elimination of opisthorchiasis.

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Prospects and Challenges towards Sustainable Liver Fluke Control

Cited by 28 publications

References 78 publications

Operationalizing One Health Employing Social-Ecological Systems Theory: Lessons From the Greater Mekong Sub-region

Operationalizing One Health Employing Social-Ecological Systems Theory: Lessons From the Greater Mekong Sub-region

Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma

Comparing the performance of urine and copro-antigen detection in evaluating Opisthorchis viverrini infection in communities with different transmission levels in Northeast Thailand

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