Prospects for Carotenoid Biofortification Targeting Retention and Catabolism

Watkins, Jacinta L.; Pogson, Barry J.

doi:10.1016/j.tplants.2019.12.021

Cited by 65 publications

(48 citation statements)

References 92 publications

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“…Carotenoids are ubiquitous organic compounds, mainly of yellow, orange and red colour, soluble in fats and organic solvents (Watkins and Pogson, 2020). Currently, more than 1100 carotenoids are known (Yabuzaki, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Currently, more than 1100 carotenoids are known (Yabuzaki, 2017). Several of these pigments are retinoids because of their vitamin A activity (Becerra et al, 2020;Watkins and Pogson, 2020). From the chemical point of view, these compounds are predominantly tetraterpenes composed of eight isoprene units.…”

Section: Introductionmentioning

confidence: 99%

“…Human bodies are not able to synthesize carotenoids themselves, so they have to take them in food or food supplements (Woodside et al, 2015). The most important sources of xanthophylls include fruits, vegetables, and some plant species such as Marigold flowers (Lin et al, 2015;Watkins and Pogson, 2020). Tagetes erecta is the most often used source of lutein and zea xanthin for food supplements production on the Czech market.…”

Section: Introductionmentioning

confidence: 99%

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Determination of carotenoids in flowers and food supplements by HPLC-DAD

Pavelková

Krmela

Schulzová

2020

Acta Chimica Slovaca

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Marigold flowers (Tagetes patula and Calendula officinalis) were chosen for analysis because they are the most often used source of lutein and its isomer zeaxanthin for the production of food supplements on the Czech market. Direct extraction and extraction with alkaline hydrolysis were compared to detect free or bound carotenoids. For carotenoid separation, C18 and C30 columns were used. A new method for determination of carotenoid content in food supplements in form of capsules has been developed and validated. All matrices were analysed by high-performance liquid chromatography with diode array detection (HPLC-DAD). It has been found that alkaline hydrolysis is required for both Marigold flowers and food supplements to release lutein from ester bonds to fatty acids. In Calendula officinalis lutein in the concentration of 807—1472 mg·kg−1 of dry matter was detected. Tagetes patula has been identified as a better lutein source with the content of 5906—8677 mg·kg−1 of dry matter. It has been found that the content of lutein and zeaxanthin in commercial food supplements (Lutein Complex Premium and Occutein Brillant) is consistent with the declared quantity. Linearity of the HPLC-DAD method ranged from 0.1—20 μg·mL−1 with the limit of quantification (LOQ) of 1.7 mg·kg−1 for lutein in Marigold flowers and 200 mg·kg−1 in food supplements. Repeatability was 2.3 % for lutein in all tested matrices.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determination of carotenoids in flowers and food supplements by HPLC-DAD

Pavelková

Krmela

Schulzová

2020

Acta Chimica Slovaca

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“…Possible beneficial effects of vitamin A and carotenoids on cardiovascular diseases and cancer (Bhatt and Patel 2020) require better knowledge. The feasibility of reaching higher amounts in plants (Watkins and Pogson 2020) with conserved bioavailability is a challenge for the future. A first step would be to define more efficiently its equivalence to retinol, a piece of data that is still elusive.…”

Section: Perspectivesmentioning

confidence: 99%

Plant Kingdom as Source of Vitamins

Hennebelle¹

2020

Handbook of Dietary Phytochemicals

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A vitamin is an organic substance necessary, in small quantities, for the correct functioning of the metabolism of a living organism. It is an essential nutrient because this substance cannot be synthesized in sufficient quantity by this organism and thus must be provided through the food intake. Each organism has specific needs: a molecule can be a vitamin for one species and not be it for another. It is the case for example of Vitamin C. Some vitamins are water-soluble compounds, including all vitamin Bs (B1, B2, B3, B5, B6, B7, B9, B12) and vitamin C. Others are fat-soluble compounds and encompass vitamins A, D, E, and K. In this chapter, we have chosen to provide an overview of recent literature data only about vitamins provided exclusively or significantly by plant food, in particular vitamins A (as provitaminic carotenoids), B1, B9, C, E, and K1. Vitamins provided by animal food, such as vitamin D or vitamin B12, will be not discussed in this chapter.

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“…It has been suggested that increased consumption of pro-VA β-carotene (BC) enriched foods can increase body stores of VA [ 19 , 20 ]. The alga Dunaliella bardawil is a natural source of BC, containing mainly all-trans and 9-cis BC isomers.…”

Section: Introductionmentioning

confidence: 99%

Dietary β-Carotene Rescues Vitamin A Deficiency and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice

et al. 2020

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Vitamin A deficiency (VAD) is a major health problem, especially in developing countries. In this study, we investigated the effect of VAD from weaning to adulthood in apoE−/− mice. Three-week-old male mice were allocated into four diet groups: I. VAD II. VAD+vitamin A (VA), 1500 IU retinyl-palmitate; III. VAD+β-carotene (BC), 6 g/kg feed, containing 50% all-trans and 50% 9-cis BC. IV. VAD with BC and VA (BC+VA). After 13 weeks, we assessed the size of atherosclerotic plaques and measured VA in tissues and BC in plasma and tissues. VAD resulted in diminished hepatic VA levels and undetectable brain VA levels compared to the other groups. BC completely replenished VA levels in the liver, and BC+VA led to a two-fold elevation of hepatic VA accumulation. In adipose tissue, mice fed BC+VA accumulated only 13% BC compared to mice fed BC alone. Atherosclerotic lesion area of BC group was 73% lower compared to VAD group (p < 0.05). These results suggest that BC can be a sole source for VA and inhibits atherogenesis.

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Prospects for Carotenoid Biofortification Targeting Retention and Catabolism

Cited by 65 publications

References 92 publications

Determination of carotenoids in flowers and food supplements by HPLC-DAD

Determination of carotenoids in flowers and food supplements by HPLC-DAD

Plant Kingdom as Source of Vitamins

Dietary β-Carotene Rescues Vitamin A Deficiency and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice

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