2015
DOI: 10.18097/pbmc20156101019
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Prospects for use of peptides and their derivatives, structurally corresponding to the G protein-coupled receptors, in medicine

Abstract: The regulation of signaling pathways involved in the control of many physiological functions is carried out via the heterotrimeric G protein-coupled receptors (GPCR). The search of effective and selective regulators of GPCR and intracellular signaling cascades coupled with them is one of the important problems of modern fundamental and clinical medicine. Recently data suggest that synthetic peptides and their derivatives, structurally corresponding to the intracellular and transmembrane regions of GPCR, can in… Show more

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