Prospects for Using Gold, Silver, and Iron Oxide Nanoparticles for Increasing the Efficacy of Chemotherapy

Федотчева, Т. А.; Olenin, A. Yu.; Старостин, К. М.; Лисичкин, Г. В.; Банин, В. В.; Шимановский, Н. Л.

doi:10.1007/s11094-015-1260-6

Cited by 20 publications

(8 citation statements)

References 90 publications

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“…The antibacterial properties of these M NPs are a main reason for their application in the biomedical field, textile industry, water treatment, and food industry 2,8 . In addition, there are numerous data for significant antifungal activity, anticancer potential, antiviral, anti‐angiogenic, and anti‐inflammatory properties of different types of Ag NPs and Cu NPs 1,7,9–11 . As a rule, in studies of the antibacterial properties of M NPs, only the characteristics of M NPs, such as size, structure, and chemical state, are analyzed, but the chemical composition of the environment is ignored, which can significantly affect the properties of the prepared material.…”

Section: Introductionmentioning

confidence: 99%

XPS study of silver and copper nanoparticles demonstrated selective anticancer, proapoptotic, and antibacterial properties

Vasil’kov

Batsalova

Dzhambazov

et al. 2021

Surface & Interface Analysis

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Silver and copper nanoparticles were produced by an ecologically safe metal vapor synthesis (MVS) method using acetone as an organic dispersion medium. Transmission electron microscopy (TEM) showed that the specimens are spherical and polydisperse, and their average size is 2.5 nm for silver nanoparticles (Ag NPs) and 2.6 nm for copper nanoparticles (Cu NPs). X‐ray photoelectron spectroscopy analyses showed that the state of silver in the nanoparticles is close to that of silver in the Ag0 state, whereas copper black contains two oxidized states of the metal—Cu+ and Cu2+. Biological in vitro studies demonstrated that the nanoparticles have antibacterial activity against Gram‐positive and Gram‐negative bacterial species. Cu NPs exhibited more prominent antibacterial effects and induced significant growth inhibition of Bacillus cereus and Escherichia coli. Both types of nanoparticles showed anticancer properties in vitro. Cu NPs induced intense cytotoxicity in cancer and normal fibroblasts in vitro cultures, but their inhibitory effect against noncancerous cells was milder compared with cancer cell lines. Ag NPs demonstrated selective cytotoxicity against human lung and cervical adenocarcinoma cell lines. Further in vitro studies indicated that the mechanism of Ag NPs and Cu NPs anticancer effects involves induction of apoptosis. The present study describes a green synthesis approach for production of biologically active silver and copper nanoparticles and highlights their potential for medical application.

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Section: Introductionmentioning

confidence: 99%

XPS study of silver and copper nanoparticles demonstrated selective anticancer, proapoptotic, and antibacterial properties

Vasil’kov

Batsalova

Dzhambazov

et al. 2021

Surface & Interface Analysis

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“…Despite notable improvements in recent years in the development of new therapeutic approaches, due to a better knowledge about drugs physicochemical properties and the mechanisms of their cellular uptake, many of the antitumor drugs commonly used in chemotherapy still present significant adverse effects and, often, a poor efficacy. [1][2][3][4][5] These usual issues for drugs in oncologic treatments normally resulted in lack of specificity. Moreover some drugs show poor solubility, stability or are rapidly eliminated.…”

Section: Introductionmentioning

confidence: 99%

“…Despite notable improvements in recent years in the development of new therapeutic approaches, due to a better knowledge about the physicochemical properties of drugs and the mechanisms of their cellular uptake, many of the antitumor drugs commonly used in chemotherapy still present significant adverse effects and, often, poor efficacy. − These usual issues of drugs in oncologic treatments normally result in lack of specificity. Moreover, some drugs show poor solubility and stability or are rapidly eliminated. − In this context, nanomedicine attempts to offer a broad variety of tools aimed to improve the conventional therapeutic and diagnostic strategies, for the development of more effective and safer treatments, reducing toxicity of drugs to nontarget organs. − …”

Section: Introductionmentioning

confidence: 99%

Polyglutamic Acid-Gated Mesoporous Silica Nanoparticles for Enzyme-Controlled Drug Delivery

et al. 2016

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Mesoporous silica nanoparticles (MSNs) are highly attractive as supports in the design of controlled delivery systems that can act as containers for the encapsulation of therapeutic agents, overcoming common issues such as poor water solubility and poor stability of some drugs and also enhancing their bioavailability. In this context, we describe herein the development of polyglutamic acid (PGA)-capped MSNs that can selectively deliver rhodamine B and doxorubicin. PGA-capped MSNs remain closed in an aqueous environment, yet they are able to deliver the cargo in the presence of pronase because of the hydrolysis of the peptide bonds in PGA. The prepared solids released less than 20% of the cargo in 1 day in water, whereas they were able to reach 90% of the maximum release of the entrapped guest in ca. 5 h in the presence of pronase. Studies of the PGA-capped nanoparticles with SK-BR-3 breast cancer cells were also undertaken. Rhodamine-loaded nanoparticles were not toxic, whereas doxorubicin-loaded nanoparticles were able to efficiently kill more than 90% of the cancer cells at a concentration of 100 μg/mL.

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“…Typically, 12 nm GNPs modified with chitosan have a protective effect on brain and liver tissues against lipopolysaccharide-induced tissue toxicity 124 . Active targeting modifications of GNPs might effectively decrease their unnecessary tissue accumulation and consequently their tissue toxicity 125 . Accordingly, the toxicity of GNPs is relative and complex, and their safety assessment also requires systematic examination 126 .…”

Section: Discussionmentioning

confidence: 99%

Gold-based nanomaterials for the treatment of brain cancer

Luo

et al. 2021

Cancer Biol. Med.

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Brain cancer, also known as intracranial cancer, is one of the most invasive and fatal cancers affecting people of all ages. Despite the great advances in medical technology, improvements in transporting drugs into brain tissue have been limited by the challenge of crossing the blood-brain barrier (BBB). Fortunately, recent endeavors using gold-based nanomaterials (GBNs) have indicated the potential of these materials to cross the BBB. Therefore, GBNs might be an attractive therapeutic strategy against brain cancer. Herein, we aim to present a comprehensive summary of current understanding of the critical effects of the physicochemical properties and surface modifications of GBNs on BBB penetration for applications in brain cancer treatment. Furthermore, the most recent GBNs and their impressive performance in precise bioimaging and efficient inhibition of brain tumors are also summarized, with an emphasis on the mechanism of their effective BBB penetration. Finally, the challenges and future outlook in using GBNs for brain cancer treatment are discussed. We hope that this review will spark researchers' interest in constructing more powerful nanoplatforms for brain disease treatment.

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Prospects for Using Gold, Silver, and Iron Oxide Nanoparticles for Increasing the Efficacy of Chemotherapy

Cited by 20 publications

References 90 publications

XPS study of silver and copper nanoparticles demonstrated selective anticancer, proapoptotic, and antibacterial properties

XPS study of silver and copper nanoparticles demonstrated selective anticancer, proapoptotic, and antibacterial properties

Polyglutamic Acid-Gated Mesoporous Silica Nanoparticles for Enzyme-Controlled Drug Delivery

Gold-based nanomaterials for the treatment of brain cancer

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