Prospects of Coffee Leaf against SARS-CoV-2 Infection

Wu, Chen-Shiou; Chiang, Hsiu-Mei; Chen, Yeh; Chen, Hsiao-Fan; Su, Wu‐Chung; Wang, Wei‐Jan; Chou, Yu‐Chi; Chang, Wei‐Chao; Wang, Shao‐Chun; Hung, Mien‐Chie

doi:10.7150/ijbs.76058

Cited by 13 publications

(3 citation statements)

References 56 publications

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“…This process produces the waste that is normally used for compost or cattle feed. Meanwhile, it has been reported that coffee leaf contains antioxidants and many other bioactive compounds It has also been reported that the coffee leaf can be potentially developed as functional products [1,2].…”

Section: Introductionmentioning

confidence: 99%

Consumer perception of decocted coffee leaf tea originated from different altitude

Fibrianto,

Sholihah,

Bimo

2024

IOP Conf. Ser.: Earth Environ. Sci.

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It is commonly known that plantation location influences the composition of the coffee component as well as the leaves. Therefore, it was expected that the difference location will also affect the quality of decocted one. In this current study, effect of plantation location is investigated on Arabica and Robusta coffee leaf tea. Two different coffee plantations were chosen as the region of observation (560 ASL and 1700 ASL). All the coffee leaf tea was brewed by decoction method, in which sensorially optimized by Just about Right (JAR) method. The sensory attributes of concern were included sweet, sour, bitter taste and astringent mouth-feel. Considering consumer preference on the brewed coffee leaf tea, the decoction brewing condition were set on 95°C for 5 minutes. Additionally, coffee leaf tea grown at higher altitudes exhibits significantly greater total phenolic content (TPC) and antioxidant activity (p < 0.05). Not only does this tea have higher TPC and antioxidant activity at higher altitudes, but it also shows superior consumer sensory acceptability. This may be supported by the fact that higher altitude coffee leaf tea has more diverse sensory driver components than that of lower altitude coffee leaf tea as suggested by LC-MS.

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Section: Introductionmentioning

confidence: 99%

Consumer perception of decocted coffee leaf tea originated from different altitude

Fibrianto,

Sholihah,

Bimo

2024

IOP Conf. Ser.: Earth Environ. Sci.

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“…Therefore, natural plant extracts have been explored for AD treatment. Coffea arabica (Rubiaceae) leaves, containing high levels of phenolic compounds, exhibit strong antioxidant activity and inhibit the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection [17,18]. We previously reported that C. arabica extract (CAE) containing chlorogenic acid (48.3 mg/g) and a small amount of caffeic acid exhibits antioxidant, anti-photoaging, and anti-inflammatory activities in human skin fibroblasts and null mice [19,20].…”

Section: Introductionmentioning

confidence: 99%

Coffea arabica Extract Attenuates Atopic Dermatitis-like Skin Lesions by Regulating NLRP3 Inflammasome Expression and Skin Barrier Functions

Chang

Lyu

et al. 2023

IJMS

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Atopic dermatitis (AD) is a common skin disease worldwide. The major causes of AD are skin barrier defects, immune dysfunction, and oxidative stress. In this study, we investigated the anti-oxidation and anti-inflammation effects of Coffea arabica extract (CAE) and its regulation of the skin barrier and immune functions in AD. In vitro experiments revealed that CAE decreased the reactive oxygen species levels and inhibited the translocation of nuclear factor-κB (NF-κB), further reducing the secretion of interleukin (IL)-1β and IL-6 induced by interferon-γ (IFN-γ)/tumor necrosis factor-α (TNF-α). Moreover, CAE decreased IFN-γ/TNF-α-induced NLR family pyrin domain-containing 3 (NLRP3), caspase-1, high-mobility group box 1 (HMGB1), and receptor for advanced glycation end products (RAGE) expression levels. It also restored the protein levels of skin barrier function-related markers including filaggrin and claudin-1. In vivo experiments revealed that CAE not only reduced the redness of the backs of mice caused by 2,4-dinitrochlorobenzene (DNCB) but also reduced the levels of pro-inflammatory factors in their skin. CAE also reduced transepidermal water loss (TEWL) and immune cell infiltration in DNCB-treated mice. Overall, CAE exerted anti-oxidation and anti-inflammation effects and ameliorated skin barrier dysfunction, suggesting its potential as an active ingredient for AD treatment.

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“…We previously showed that several natural products including the natural polyphenol compound tannic acid are potent inhibitors of TMPRSS2 and M pro ( Huang et al, 2020 ; Wang et al, 2022b ; Wang et al, 2022a ; Wu et al, 2022 ). Tannic acid belongs to the unique family of tannins consisting of four subfamilies: hydrolysable tannins, condensed tannins, phlorotannins, and complex tannins.…”

Section: Introductionmentioning

confidence: 99%

The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2

Chen,

Wang,

Chen

et al. 2023

eLife

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The Coronavirus Disease 2019 (COVID-19) pandemic continues to infect people worldwide. While the vaccinated population has been increasing, the rising breakthrough infection persists in the vaccinated population. For living with the virus, the dietary guidelines to prevent virus infection are worthy of and timely to develop further. Tannic acid has been demonstrated to be an effective inhibitor of coronavirus and is under clinical trial. Here we found that two other members of the tannins family, oligomeric proanthocyanidins (OPCs) and punicalagin, are also potent inhibitors against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with different mechanisms. OPCs and punicalagin showed inhibitory activity against omicron variants of SARS-CoV-2 infection. The water extractant of the grape seed was rich in OPCs and also exhibited the strongest inhibitory activities for viral entry of wild-type and other variants in vitro. Moreover, we evaluated the inhibitory activity of grape seed extractants (GSE) supplementation against SARS-CoV-2 viral entry in vivo and observed that serum samples from the healthy human subjects had suppressive activity against different variants of SARS-CoV-2 Vpp infection after taking GSE capsules. Our results suggest that natural tannins acted as potent inhibitors against SARS-CoV-2 infection, and GSE supplementation could serve as healthy food for infection prevention.

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Prospects of Coffee Leaf against SARS-CoV-2 Infection

Cited by 13 publications

References 56 publications

Consumer perception of decocted coffee leaf tea originated from different altitude

Consumer perception of decocted coffee leaf tea originated from different altitude

Coffea arabica Extract Attenuates Atopic Dermatitis-like Skin Lesions by Regulating NLRP3 Inflammasome Expression and Skin Barrier Functions

The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2

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