The peculiarities of the microstructure of welded joints of single crystals of heat-resistant nickel alloys made by electron beam welding are considered. The main structural areas of the welded joint are identified: the base metal, the heat effect zone (HAZ), the fusion area, the epitaxial growth zone, the weld sections corresponding to different deviations of the maximum heat dissipation from the orientation of the predominant crystal growth. The dependences of the structure of separate areas, their sizes from the initial crystallographic orientation of the single crystal, the brand of the studied alloy, temperature-temporal and temperature-spatial parameters of the process, determined mainly by welding modes, are established. HAZ is dominated by changes (γ + γ′)-structures consisting in complete or partial dissolution of the primary γ′-phase, large globular eutectic formations with subsequent (upon cooling) separation of the dispersed nanosized secondary γ′-phase. The weld metal is characterized by more noticeable changes in the dendritic structure-variables in the cross section of the weld, its parameters and morphology, a decrease in chemical inhomogeneity compared to the original metal.