Prospects of Neoadjuvant Chemoradiotherapy in Patients With Stage Iii a Non-Small Cell Lung Cancer as a Method of Improving Survival

Maliarchuk, Katerina; Ganul, Andrey V; Borisyuk, Bogdan O; Bororov, Leonid V; Shevchenko, Anatoly; Sovenko, V.

doi:10.36740/wlek202209109

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…Лікування недрібноклітинного раку легені III стадії а (НМРЛ) незважаючи на комбіноване і комплексне лікування не дозволяє забезпечити високу виживаність -за даними Українського канцер-реєстру 58% пацієнтів живуть не більше року після постановки діагнозу [1]. У попередніх дослідженнях ми провели порівняльний аналіз виживання пацієнтів після НХТ, НХЛТ і НХТ + ад'ювантна ЛТ і встановили, що НХЛТ дає переваги щодо тривалості життя пацієнтів [2][3][4]. Встановлено, що найважливішим аспектом лікуваль-ної стратегії є токсичність лікування та ризики, які воно створює для пацієнтів.…”

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Comparison of Early Treatment- Emergent Complications of Stage Iii a Non-Small Cell Carcinoma (Nsclc Stage Iii A) in Patients Treated With Neoadjuvant Chemoradiotherapy (Nhlt), (Ncht), and Neoadjuvant Chemotherapy and Adjuvant Radiation Therapy

Malyarchuk,

Ganul,

Borysyuk

et al. 2023

Clin. and prev. med.

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Treatment of STAGE III A NSCLC is an extremely difficult problem for modern oncology, since the one-year survival rate from the moment of diagnosis according to the National Cancer Registry is up to 58%. At the same time, there is a situation of uncertainty in the clinical approach to the treatment of this pathology – neither NCCN nor other world scientific literature sources contain information regarding a specific treatment method. The advantage of none of the possible methods of treatment of stage III NSCLC (HCT, NHLT, HCT + adjuvant PT) is not proven in relation to others. The conducted study is devoted to comparing these methods in relation to each other and overall and relapse-free survival. According to the results of previous studies, the highest results of both general and relapse-free survival were shown by patients from the NHLT group. But an important aspect of treatment is the ratio of benefit and risk, that is, the number and severity of complications. The study and analysis of complications of treatment with the methods of NXT, NHLT and NXT + adjuvant PT was the task of the work. Goal. To investigate and determine the number of complications in groups with NCRT, NCT and NCT + adjuvant LT. Materials and methods. The study included 3 groups of patients – patients who received NHLT, NHT and NHT + adjuvant PT, a total of 304 people. All patients had the same chemotherapy regimen- Cisplatin / Docetaxel or Carboplatin / Paclitaxel, patients receiving radiation therapy received it in a total dosage of 30 Gy in both neoadjuvant and adjuvant regimens. The irradiation was carried out on the chest and mediastinum area. Patients underwent radical surgery in the form of lobectomy, bilobectomy or pneumonectomy. In early works on this topic, an analysis of survival on the Kaplan and Mayer scale was carried out. The article describes the conduct and study of treatment complications that were recorded during the stay of patients in the hospital both during chemotherapy, radiation therapy and in the postoperative period.

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